Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Robert S Moreland"'
Publikováno v:
Frontiers in Pharmacology, Vol 2 (2012)
Contraction of bladder smooth muscle is predominantly initiated by M3 muscarinic receptor-mediated activation of the Gq/11-phospholipase C β-protein kinase C (PKC) and the G12/13-RhoGEF-Rho kinase (ROCK) pathways. However, these pathways and their d
Externí odkaz:
https://doaj.org/article/a6db58d19a044009a600e6cdfb6b64a7
Publikováno v:
European Journal of Pharmacology. 720:355-362
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that contracts most smooth muscles. Although S1P has been shown to contract bladder smooth muscle, the mechanism(s) by which S1P initiates contraction has not been extensively investigated. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18817fa37330e585594d88974523945d
https://doi.org/10.1016/j.ejphar.2013.10.004
https://doi.org/10.1016/j.ejphar.2013.10.004
Publikováno v:
Frontiers in Pharmacology
Vascular smooth muscle (VSM) is unique in its ability to maintain an intrinsic level of contractile force, known as tone. Vascular tone is believed to arise from the constitutive activity of membrane-bound L-type Ca2+ channels (LTCC). This study used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7607c37142d4a33165ea277c71e60a04
Autor:
Danielle M. Trappanese, Michael V. Autieri, Hillevi Ets, Sarah Sivilich, Robert S. Moreland, Farah Kako
Vascular smooth muscle contraction is primarily regulated by phosphorylation of myosin light chain. There are also modulatory pathways that control the final level of force development. We tested the hypothesis that protein kinase C (PKC) and mitogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e24fbf18680ad4cbcfde498f4364c5
https://europepmc.org/articles/PMC4935203/
https://europepmc.org/articles/PMC4935203/
Type II diabetes is the most prevalent form of diabetes. One of the primary complications of diabetes that significantly affects quality of life is bladder dysfunction. Many studies on diabetic bladder dysfunction have been performed in models of typ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f48720f2b9934715ab4430c702caf1a1
https://europepmc.org/articles/PMC4867315/
https://europepmc.org/articles/PMC4867315/
Autor:
Robert S. Moreland, Nicole Klee
Publikováno v:
Translational Andrology and Urology
Objective Bladder smooth muscle (detrusor muscle) undergoes temporal changes in response to diabetes resulting in diabetic bladder dysfunction (DBD). Type I DBD induces an early compensated state of bladder function exhibiting detrusor muscle remodel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4031c942aef0e5f5030ceda5ab99ab
http://europepmc.org/articles/PMC5143230
http://europepmc.org/articles/PMC5143230
Publikováno v:
European Journal of Organic Chemistry. 2009:3258-3264
Ethyl 1,2-dihydro-1,6-dimethyl/6-methyl-2-oxopyrimidine-5-carboxylates react with C-nucleophiles as well as the anion of the enantiopure chiral auxiliary (1R,2S,5R)-(–)-methyl (S)-p-toluenesulfinate to afford 4-substituted and enantiopure congeners
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009457d993f77a8433e1d9068522aeb3
https://doi.org/10.1002/ejoc.200900208
https://doi.org/10.1002/ejoc.200900208
Autor:
Robert S. Moreland, Elaine M. Smolock, Samuel Chacko, Shaohua Chang, Alan J. Wein, Maureen Basha
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 291:R1076-R1084
Contractility of the proximal and distal vaginal wall smooth muscle may play distinct roles in the female sexual response and pelvic support. The goal of this study was to determine whether differences in contractile characteristics of smooth muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f957fbb749b09001a005e6a53f7b4247
https://doi.org/10.1152/ajpregu.00118.2006
https://doi.org/10.1152/ajpregu.00118.2006
Autor:
Anatoly Soloviev, Irina V. Ivanova, Sergey Tishkin, S.N. Zelensky, Robert S. Moreland, Igor V. Kizub, Alexandra A. Pavlova
Publikováno v:
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 289:R755-R762
Radiation exposure increases vascular responsiveness, and this change involves endothelial damage, as well as direct effects on vascular smooth muscle. In this study, we tested the hypothesis that myofilament Ca2+sensitivity in vascular smooth muscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3ae821c18405a975c37084724ab373
https://doi.org/10.1152/ajpregu.00748.2004
https://doi.org/10.1152/ajpregu.00748.2004
Publikováno v:
European Journal of Pharmacology. 476:201-209
We tested the hypothesis that the differential sensitivity of rabbit aorta and mesenteric artery to norepinephrine is due to tyrosine kinase activity. The EC50 of aorta to norepinephrine was 6.5 times more sensitive than that in mesenteric artery. Ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ffaad248785ed5b9bb122ba7443a22
https://doi.org/10.1016/s0014-2999(03)02183-6
https://doi.org/10.1016/s0014-2999(03)02183-6