Zobrazeno 1 - 10
of 428
pro vyhledávání: '"Robert S Kerbel"'
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 7, Pp 1-22 (2021)
Abstract Anti‐angiogenic drugs targeting the VEGF pathway are most effective in advanced metastatic disease settings of certain types of cancers, whereas they have been unsuccessful as adjuvant therapies of micrometastatic disease in numerous phase
Externí odkaz:
https://doaj.org/article/417e057c74bb46a1888ab3dffa1e68fd
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-12 (2020)
Abstract Conventional maximum‐tolerated dose (MTD) chemotherapy relies on periodic, massive cancer cell ablation events followed by treatment‐free intermissions, stereotypically resulting in resistance, relapse, and mortality. Furthermore, MTD ch
Externí odkaz:
https://doaj.org/article/0b3e5cb868fd4fc29e19318ae9960787
Autor:
Kabir A Khan, Robert S Kerbel
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 6, Pp 1-3 (2020)
Abstract Targeting the metastatic process is a critical pursuit in the treatment of malignant disease. There are currently no specific anti‐metastatic drugs approved for clinical use, despite metastasis being the leading cause of death for cancer p
Externí odkaz:
https://doaj.org/article/eb4499965ff341a6b6223d8c0543eb68
Autor:
Raquel Muñoz, Denise Hileeto, William Cruz-Muñoz, Geoffrey A Wood, Ping Xu, Shan Man, Alicia Viloria-Petit, Robert S Kerbel
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0222580 (2019)
Metronomic chemotherapy using the 5-FU prodrug uracil-tegafur (UFT) and cyclophosphamide (CTX) was previously shown to only modestly delay primary tumor growth, but nevertheless markedly suppressed the development of micro-metastasis in an orthotopic
Externí odkaz:
https://doaj.org/article/887d9a76c7014cc09b1151516c978166
Autor:
Florence TH Wu, Christina R Lee, Elena Bogdanovic, Aaron Prodeus, Jean Gariépy, Robert S Kerbel
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 6, Pp 770-787 (2015)
Abstract Angiopoietin‐1 (Ang1) activation of Tie2 receptors on endothelial cells (ECs) reduces adhesion by tumor cells (TCs) and limits junctional permeability to TC diapedesis. We hypothesized that systemic therapy with Vasculotide (VT)—a purpor
Externí odkaz:
https://doaj.org/article/9296c4a55b5940f0ba53e07b1e06dbcd
Autor:
John ML Ebos, Michalis Mastri, Christina R Lee, Amanda Tracz, John M Hudson, Kristopher Attwood, William R Cruz‐Munoz, Christopher Jedeszko, Peter Burns, Robert S Kerbel
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 12, Pp 1561-1576 (2014)
Abstract Thousands of cancer patients are currently in clinical trials evaluating antiangiogenic therapy in the neoadjuvant setting, which is the treatment of localized primary tumors prior to surgical intervention. The rationale is that shrinking a
Externí odkaz:
https://doaj.org/article/844253b3fa4944e1adfe6895a2c653b1
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158034 (2016)
Several approaches are being evaluated to improve the historically limited value of studying transplanted primary tumors derived by injection of cells from established cell lines for predicting subsequent cancer therapy outcomes in patients and clini
Externí odkaz:
https://doaj.org/article/ba1c2a9cd7224106be427e0af88c80fd
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71270 (2013)
We compare for the first time, the metastatic aggressiveness of the parental MDA-MB-231 breast cancer cell line and two luciferase-tagged in vivo-derived and selected pro-metastatic variants (LM2-4/luc⁺ and 164/8-1B/luc⁺ in SCID, NOD-SCID and NOD
Externí odkaz:
https://doaj.org/article/ddacaa41dde14678a8057a6ad261d61b
Autor:
Alessia Ciarrocchi, Vladimir Jankovic, Yuval Shaked, Daniel J Nolan, Vivek Mittal, Robert S Kerbel, Stephen D Nimer, Robert Benezra
Publikováno v:
PLoS ONE, Vol 2, Iss 12, p e1338 (2007)
Loss of Id1 in the bone marrow (BM) severely impairs tumor angiogenesis resulting in significant inhibition of tumor growth. This phenotype has been associated with the absence of circulating endothelial progenitor cells (EPCs) in the peripheral bloo
Externí odkaz:
https://doaj.org/article/df855b462cad48e989f71fa79d31ad83
Autor:
John M.L. Ebos, Yuhao Shi, Melissa Dolan, Robert S. Kerbel, Amanda Tracz, Christina R. Lee, Michalis Mastri
List of all gene set enrichment analysis for each drug with NES, NOM-p values, and Weight Rank Score.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfef2c7cca6bec9816291018da4da9b
https://doi.org/10.1158/1535-7163.22507021
https://doi.org/10.1158/1535-7163.22507021
