Zobrazeno 1 - 10
of 444
pro vyhledávání: '"Robert S Hodges"'
Autor:
Miguel A Lanaspa, Christina Cicerchi, Gabriela Garcia, Nanxing Li, Carlos A Roncal-Jimenez, Christopher J Rivard, Brandi Hunter, Ana Andrés-Hernando, Takuji Ishimoto, Laura G Sánchez-Lozada, Jeffrey Thomas, Robert S Hodges, Colin T Mant, Richard J Johnson
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48801 (2012)
Fatty liver (hepatic steatosis) is associated with nucleotide turnover, loss of ATP and generation of adenosine monophosphate (AMP). It is well known that in fatty liver, activity of the AMP-activated kinase (AMPK) is reduced and that its stimulation
Externí odkaz:
https://doaj.org/article/369516d1f66e4fc6b0d44af97816fe5c
Autor:
Sheryl Zajdowicz, Jon C Haller, Amy E Krafft, Steve W Hunsucker, Colin T Mant, Mark W Duncan, Robert S Hodges, David N M Jones, Randall K Holmes
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34591 (2012)
During infection, Corynebacterium diphtheriae must compete with host iron-sequestering mechanisms for iron. C. diphtheriae can acquire iron by a siderophore-dependent iron-uptake pathway, by uptake and degradation of heme, or both. Previous studies s
Externí odkaz:
https://doaj.org/article/71d2dd2f74cf44348ba71f7c3cb1ef4b
Autor:
Myriam Reffay, Yann Gambin, Houssain Benabdelhak, Gilles Phan, Nicolas Taulier, Arnaud Ducruix, Robert S Hodges, Wladimir Urbach
Publikováno v:
PLoS ONE, Vol 4, Iss 4, p e5035 (2009)
Membrane proteins are essential in the exchange processes of cells. In spite of great breakthrough in soluble proteins studies, membrane proteins structures, functions and interactions are still a challenge because of the difficulties related to thei
Externí odkaz:
https://doaj.org/article/bf67285bee3046f59534bf65e4c3a57e
Autor:
Rui Zhao, Xiaowei Ma, Lijuan Bai, Xin Li, Kenza Mamouni, Yang Yang, HongYan Liu, Alira Danaher, Nicholas Cook, Omer Kucuk, Robert S. Hodges, Lajos Gera, Daqing Wu
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1261-1274 (2021)
A major challenge to the treatment of advanced prostate cancer (PCa) is the development of resistance to androgen-deprivation therapy (ADT) and chemotherapy. It is imperative to discover effective therapies to overcome drug resistance and improve cli
Externí odkaz:
https://doaj.org/article/1f6b060eb516456db0aa542c6160f224
Autor:
Xin Li, Robert S. Hodges, Kenza Mamouni, Hong Yan Liu, Lajos Gera, Rui Zhao, Alira Danaher, Lijuan Bai, Nicholas Cook, Xiaowei Ma, Omer Kucuk, Yang Yang, Daqing Wu
Publikováno v:
Neoplasia (New York, N.Y.)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1261-1274 (2021)
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 12, Pp 1261-1274 (2021)
A major challenge to the treatment of advanced prostate cancer (PCa) is the development of resistance to androgen-deprivation therapy (ADT) and chemotherapy. It is imperative to discover effective therapies to overcome drug resistance and improve cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a832ce1861512439071b5f1c6c32f2
https://doi.org/10.1016/j.neo.2021.11.006
https://doi.org/10.1016/j.neo.2021.11.006
Publikováno v:
Journal of medicinal chemistry and drug design
We designed de novo and synthesized two series of five 26-residue amphipathic α-helical cationic antimicrobial peptides (AMPs) with five or six positively charged residues (D-Lys, L-Dab (2,4-diaminobutyric acid) or L-Dap (2,3-diaminopropionic acid))
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2920425555f3305df06d5e6369c4bd0c
https://pubmed.ncbi.nlm.nih.gov/34377965
https://pubmed.ncbi.nlm.nih.gov/34377965
Autor:
Aaron Griffin, Robert S. Hodges, Parker J. Nichols, Liliya Vugmeyster, Christopher J. McKnight, Beat Vögeli, Isaac B. Falconer, Colin T. Mant
Publikováno v:
Protein Sci
We have investigated the effect of deuteration of non‐exchangeable protons on protein global thermal stability, hydrophobicity, and local flexibility using well‐known thermostable model systems such as the villin headpiece subdomain (HP36) and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29bb9fdd1283873977cb67841bda483e
https://europepmc.org/articles/PMC7314392/
https://europepmc.org/articles/PMC7314392/
Publikováno v:
Chemical Biology & Drug Design. 91:75-92
We have designed de novo and synthesized eight 26-residue all D-conformation amphipathic α-helical cationic antimicrobial peptides (AMPs), four with "specificity determinants" which provide specificity for prokaryotic cells over eukaryotic cells and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d119568bcd8186201f06acf3f7ed75
https://doi.org/10.1111/cbdd.13058
https://doi.org/10.1111/cbdd.13058
Autor:
Tavia Caplan, Doreen E. Culham, Janet M. Wood, Robert S. Hodges, Jennifer Garner, Tatyana Romantsov
Publikováno v:
Molecular Microbiology. 103:469-482
Osmosensing transporter ProP protects bacteria from osmotically-induced dehydration by mediating the uptake of zwitterionic osmolytes. ProP activity is a sigmoidal function of the osmolality. ProP orthologues share an extended, cytoplasmic C-terminal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aece4ae6f7bfebcd85e0b2bd7cf671e4
https://doi.org/10.1111/mmi.13569
https://doi.org/10.1111/mmi.13569
Autor:
Jonathan A. Shortt, David D. Pollock, Lajos Gera, Zhe Yan, Brooke Hirsch, Robert S. Hodges, Kathryn V. Holmes, Colin T. Mant, Zhaohui Qian, Ziqing Jiang
Publikováno v:
Biopolymers. 106:144-159
We have utilized a de novo designed two-stranded α-helical coiled-coil template to display conserved α-helical epitopes from the stem region of hemagglutinin (HA) glycoproteins of influenza A. The immunogens have all the surface-exposed residues of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d3295b0ed82c55ed5c00b419f1441d3
https://doi.org/10.1002/bip.22808
https://doi.org/10.1002/bip.22808