Zobrazeno 1 - 10
of 189
pro vyhledávání: '"Robert S Haltiwanger"'
Autor:
Emilia Servián‐Morilla, Hideyuki Takeuchi, Tom V Lee, Jordi Clarimon, Fabiola Mavillard, Estela Area‐Gómez, Eloy Rivas, Jose L Nieto‐González, Maria C Rivero, Macarena Cabrera‐Serrano, Leonardo Gómez‐Sánchez, Jose A Martínez‐López, Beatriz Estrada, Celedonio Márquez, Yolanda Morgado, Xavier Suárez‐Calvet, Guillermo Pita, Anne Bigot, Eduard Gallardo, Rafael Fernández‐Chacón, Michio Hirano, Robert S Haltiwanger, Hamed Jafar‐Nejad, Carmen Paradas
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 11, Pp 1289-1309 (2016)
Abstract Skeletal muscle regeneration by muscle satellite cells is a physiological mechanism activated upon muscle damage and regulated by Notch signaling. In a family with autosomal recessive limb‐girdle muscular dystrophy, we identified a missens
Externí odkaz:
https://doaj.org/article/e129c340992648829008794a71c44bf2
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184903 (2017)
Peters Plus Syndrome (PPS) is a rare autosomal recessive disease characterized by ocular defects, short stature, brachydactyly, characteristic facial features, developmental delay and other highly variable systemic defects. Classic PPS is caused by l
Externí odkaz:
https://doaj.org/article/bcdb3411829b4944ab86c9a9dded1af2
Autor:
Nitya Ramkumar, Beth M Harvey, Jeffrey D Lee, Heather L Alcorn, Nancy F Silva-Gagliardi, C Jane McGlade, Timothy H Bestor, Jan Wijnholds, Robert S Haltiwanger, Kathryn V Anderson
Publikováno v:
PLoS Genetics, Vol 11, Iss 10, p e1005551 (2015)
Crumbs family proteins are apical transmembrane proteins with ancient roles in cell polarity. Mouse Crumbs2 mutants arrest at midgestation with abnormal neural plate morphology and a deficit of mesoderm caused by defects in gastrulation. We identifie
Externí odkaz:
https://doaj.org/article/8ca724ce38814cb8a83571574b8ca950
Autor:
Amanda R Haltom, Tom V Lee, Beth M Harvey, Jessica Leonardi, Yi-Jiun Chen, Yang Hong, Robert S Haltiwanger, Hamed Jafar-Nejad
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004795 (2014)
The protein O-glucosyltransferase Rumi/POGLUT1 regulates Drosophila Notch signaling by adding O-glucose residues to the Notch extracellular domain. Rumi has other predicted targets including Crumbs (Crb) and Eyes shut (Eys), both of which are involve
Externí odkaz:
https://doaj.org/article/99e0cc98618c4f37b3d959f96d1561b3
Autor:
Julia Müller, Nadia A Rana, Katrin Serth, Shinako Kakuda, Robert S Haltiwanger, Achim Gossler
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88571 (2014)
Fucosylation of Epidermal Growth Factor-like (EGF) repeats by protein O-fucosyltransferase 1 (POFUT1 in vertebrates, OFUT1 in Drosophila) is pivotal for NOTCH function. In Drosophila OFUT1 also acts as chaperone for Notch independent from its enzymat
Externí odkaz:
https://doaj.org/article/b37817be512a4b6c8a33a7728d4e7036
Autor:
Tom V Lee, Maya K Sethi, Jessica Leonardi, Nadia A Rana, Falk F R Buettner, Robert S Haltiwanger, Hans Bakker, Hamed Jafar-Nejad
Publikováno v:
PLoS Genetics, Vol 9, Iss 6, p e1003547 (2013)
The Notch signaling pathway controls a large number of processes during animal development and adult homeostasis. One of the conserved post-translational modifications of the Notch receptors is the addition of an O-linked glucose to epidermal growth
Externí odkaz:
https://doaj.org/article/37cead7c701946efb202e6a92580356e
Autor:
Steven J Berardinelli, Andrew R Sillato, Richard C Grady, Sanjiv Neupane, Atsuko Ito, Robert S Haltiwanger, Bernadette C Holdener
Publikováno v:
Glycobiology. 33:301-310
Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1’s diverse functions are attributed to interactions between the modular domains of THBS1 with an array o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::997ea14821547ecfa26d0f110f2a23dd
https://doi.org/10.1093/glycob/cwad006
https://doi.org/10.1093/glycob/cwad006
Autor:
Daniel K. Lester, Chase Burton, Alycia Gardner, Patrick Innamarato, Krithika Kodumudi, Qian Liu, Emma Adhikari, Qianqian Ming, Daniel B. Williamson, Dennie T. Frederick, Tatyana Sharova, Michael G. White, Joseph Markowitz, Biwei Cao, Jonathan Nguyen, Joseph Johnson, Matthew Beatty, Andrea Mockabee-Macias, Matthew Mercurio, Gregory Watson, Pei-Ling Chen, Susan McCarthy, Carlos MoranSegura, Jane Messina, Kerry L. Thomas, Lancia Darville, Victoria Izumi, John M. Koomen, Shari A. Pilon-Thomas, Brian Ruffell, Vincent C. Luca, Robert S. Haltiwanger, Xuefeng Wang, Jennifer A. Wargo, Genevieve M. Boland, Eric K. Lau
Publikováno v:
Nature Cancer. 4:222-239
Despite reports of striking outcomes, immunotherapy efficacy in melanoma is limited to subsets of patients 1, 2. Combining immunotherapies with other modalities has yielded limited improvements but also adverse events requiring cessation of treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a64da195ce606f3ff385fc17153f645
https://doi.org/10.1038/s43018-022-00506-7
https://doi.org/10.1038/s43018-022-00506-7
Autor:
Justin A. Grennell, Kendra D. Jenkins, Kelvin B. Luther, John Glushka, Robert S. Haltiwanger, Megan A. Macnaughtan
Publikováno v:
Biomolecular NMR Assignments. 17:27-35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5569f75a733384d49d48b59f21857aae
https://doi.org/10.1007/s12104-022-10116-0
https://doi.org/10.1007/s12104-022-10116-0
Autor:
Florian Pennarubia, Alison V. Nairn, Megumi Takeuchi, Kelley W. Moremen, Robert S. Haltiwanger
Publikováno v:
Molecules, Vol 26, Iss 19, p 5942 (2021)
Fringes are glycosyltransferases that transfer a GlcNAc to O-fucose residues on Epidermal Growth Factor-like (EGF) repeats. Three Fringes exist in mammals: LUNATIC FRINGE (LFNG), MANIC FRINGE (MFNG), and RADICAL FRINGE (RFNG). Fringe modification of
Externí odkaz:
https://doaj.org/article/7a4749df810f4d3ca393d87ec8c7957d