Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Robert S, Oakes"'
Autor:
Wenji Piao, Long Wu, Yanbao Xiong, Gregory C. Zapas, Christina M. Paluskievicz, Robert S. Oakes, Sarah M. Pettit, Margaret L. Sleeth, Keli L. Hippen, Jessica Schmitz, Philipp Ivanyi, Amol C. Shetty, Yang Song, Dejun Kong, Young Lee, Lushen Li, Marina W. Shirkey, Allison Kensiski, Aamna Alvi, Kevin Ho, Vikas Saxena, Jan H. Bräsen, Christopher M. Jewell, Bruce R. Blazar, Reza Abdi, Jonathan S. Bromberg
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Regulatory T cells (Tregs) with multifaceted functions suppress anti-tumor immunity by signaling surrounding cells. Here we report Tregs use the surface lymphotoxin (LT)α1β2 to preferentially stimulate LT beta receptor (LTβR) nonclassical
Externí odkaz:
https://doaj.org/article/ec08d3585edd480ea839e96b3bc9f2de
Autor:
Sarah L. Price, Robert S. Oakes, Rodrigo J. Gonzalez, Camilla Edwards, Amanda Brady, Jennifer K. DeMarco, Ulrich H. von Andrian, Christopher M. Jewell, Matthew B. Lawrenz
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108600- (2024)
Summary: Fleas transmit Yersinia pestis directly within the dermis of mammals to cause bubonic plague. Syringe-mediated inoculation is widely used to recapitulate bubonic plague and study Y. pestis pathogenesis. However, intradermal needle inoculatio
Externí odkaz:
https://doaj.org/article/8a28d90b249d4b2bbf3092468bce29cf
Autor:
Joshua M. Gammon, Sean T. Carey, Vikas Saxena, Haleigh B. Eppler, Shannon J. Tsai, Christina Paluskievicz, Yanbao Xiong, Lushen Li, Marian Ackun-Farmmer, Lisa H. Tostanoski, Emily A. Gosselin, Alexis A. Yanes, Xiangbin Zeng, Robert S. Oakes, Jonathan S. Bromberg, Christopher M. Jewell
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Antigen-specific tolerance represents a promising strategy to treat type 1 diabetes and islet allograft rejection. Here, the authors deliver immune signals to lymph nodes to promote antigen-specific regulatory T cells and prevent disease in models of
Externí odkaz:
https://doaj.org/article/2fe54bb72010401d8d7a7af2a350784f
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 11 (2023)
Biomaterials allow for the precision control over the combination and release of cargo needed to engineer cell outcomes. These capabilities are particularly attractive as new candidate therapies to treat autoimmune diseases, conditions where dysfunct
Externí odkaz:
https://doaj.org/article/7db5470e84ba417da2da79fc52951e1a
Autor:
Michelle L. Bookstaver, Qin Zeng, Robert S. Oakes, Senta M. Kapnick, Vikas Saxena, Camilla Edwards, Nishedhya Venkataraman, Sheneil K. Black, Xiangbin Zeng, Eugene Froimchuk, Thomas Gebhardt, Jonathan S. Bromberg, Christopher M. Jewell
Publikováno v:
Advanced Science, Vol 10, Iss 1, Pp n/a-n/a (2023)
Abstract Recent clinical studies show activating multiple innate immune pathways drives robust responses in infection and cancer. Biomaterials offer useful features to deliver multiple cargos, but add translational complexity and intrinsic immune sig
Externí odkaz:
https://doaj.org/article/07ac2af086f849e8bda97b396a8fbfd9
Autor:
Aaron H. Morris, Kevin R. Hughes, Robert S. Oakes, Michelle M. Cai, Stephen D. Miller, David N. Irani, Lonnie D. Shea
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Monitoring changes in immune phenotype during the progression of multiple sclerosis can provide insight into disease progression and inform treatment. Here the authors develop engineered biomaterial-based immunological niches for easy access to innat
Externí odkaz:
https://doaj.org/article/48cb7a477ac048fcac336e5030785778
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Biomaterials hold great promise for vaccines and immunotherapy. One emerging biomaterials technology is microneedle (MNs) delivery. MNs are arrays of micrometer-sized needles that are painless and efficiently deliver cargo to the specialized immunolo
Externí odkaz:
https://doaj.org/article/051b6af531ea43fb8853c3e10528c5a0
Publikováno v:
Nanoscale. 15:8662-8674
Microneedle Arrays (MNAs) can be tunably and electrostatically coated with combinations of adjuvants. Upon treatment, these needles elicit tunable immune cell responses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::232a53c8ff897a7ccdf665f2e5547c2c
https://doi.org/10.1039/d3nr00333g
https://doi.org/10.1039/d3nr00333g
Autor:
Lonnie D. Shea, Jacqueline S. Jeruss, Max S. Wicha, Michael D. Brooks, Rachel M. Hartfield, Joseph T. Decker, Petrina LaFaire, Matthew S. Hall, Aaron H. Morris, Yining Zhang, Pridvi Kandagatla, Sophia M. Orbach, Grace G. Bushnell, Robert S. Oakes
RT-qPCR data including: Raw Non-Normalized Cq, Reference Gene Normalized Î"Cq. Format similar to NCBI GEO template with ID_REF, Gene Symbol, Reference/Target use, Catalog Number, Assay Type, Gene Name, Alias, RefSeq Accession Number, GenBank mRNA Nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3089e117facd12a530595e74a3317804
https://doi.org/10.1158/0008-5472.22424431
https://doi.org/10.1158/0008-5472.22424431
Autor:
Lonnie D. Shea, Jacqueline S. Jeruss, Max S. Wicha, Indika Rajapakse, Haiming Chen, Scott Ronquist, Robert S. Oakes, Yining Zhang, Rachel M. Hartfield, Tejaswini P. Hardas, Grace G. Bushnell
For most cancers, metastasis is the point at which clinical treatment shifts from curative intent to extending survival. Biomaterial implants acting as a synthetic premetastatic niche recruit metastatic cancer cells and provide a survival advantage,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ad09c0c5171f7264793a3d5f2271f2f
https://doi.org/10.1158/0008-5472.c.6511566.v1
https://doi.org/10.1158/0008-5472.c.6511566.v1