Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Robert S, Ames"'
Autor:
Wensheng Xie, Marie Pariollaud, William E Wixted, Nilesh Chitnis, James Fornwald, Maggie Truong, Christina Pao, Yan Liu, Robert S Ames, James Callahan, Roberto Solari, Yolanda Sanchez, Alan Diehl, Hu Li
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119738 (2015)
Endoplasmic reticulum stress plays a critical role to restore the homeostasis of protein production in eukaryotic cells. This vital process is hence involved in many types of diseases including COPD. PERK, one branch in the ER stress signaling pathwa
Externí odkaz:
https://doaj.org/article/45880be0f2cc430391c27c8c50ecb52e
Autor:
Jeffrey M. Stadel, Henry M. Sarau, Shelagh Wilson, Jeffrey S. Culp, Brian D. Hellmig, James J. Foley, Janet Park, Alison I. Muir, Jon K. Chambers, Robert S. Ames, J. Randall Slemmon, Dean E. McNulty, Derk J. Bergsma
Publikováno v:
G Protein-Coupled Receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b48a2934c1ac3991b17c7c9fc6b9365
https://doi.org/10.1201/9780429129377-4
https://doi.org/10.1201/9780429129377-4
Autor:
Thomas D. Sweitzer, Ed Dul, Quinn Lu, Robert S. Ames, Wensheng Xie, Hu Li, Christina S. Pao, Taylor L. Graham
Publikováno v:
ASSAY and Drug Development Technologies. 10:514-524
Nuclear-factor-E2-related transcription factor 2 (Nrf2) regulates a large panel of Phase II genes and plays an important role in cell survival. Nrf2 activation has been shown as preventing cigarette smoke-induced alveolar enlargement in mice. Therefo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d29ad14aabc3578c876f193c95e77a
https://doi.org/10.1089/adt.2011.436
https://doi.org/10.1089/adt.2011.436
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1350
BacMams are modified baculoviruses that contain mammalian expression cassettes for gene delivery and expression in mammalian cells. The BacMam system combines the advantages of viral transient expression, ease in generation, and a wide cell tropism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::31ec9dcbdf6263e83fce93a27c9f0a07
https://pubmed.ncbi.nlm.nih.gov/26820855
https://pubmed.ncbi.nlm.nih.gov/26820855
Autor:
Thomas D. Sweitzer, Gatto Gregory J, Elizabeth A. Davenport, Douglas G. Johns, Robert S. Ames, Patricia M. Seitz, Rona Cooper, Fernando Ramón, Lorena A. Kallal
Publikováno v:
SLAS Discovery. 15:388-397
Superoxide affects many normal and pathogenic cellular processes, and the detection of superoxide produced by cells is therefore of interest for potential therapeutic applications. To develop a high-throughput cell-based assay for the detection of ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b907ec6dfede26aa22afa964767af747
https://doi.org/10.1177/1087057109359687
https://doi.org/10.1177/1087057109359687
Autor:
John J. Kerrigan, Dulcie B. Schmidt, James J. Foley, Abby J. Sukman, Tia Lewis, Patrick McDevitt, Kathleen T. Gallagher, Kyung O. Johanson, Robert S. Ames, James A. Fornwald, Taylor L. Graham, Matthew C. Burns, Quinn Lu, Xiaoyan Tang, Gerald E. Hunsberger
Publikováno v:
Protein Expression and Purification. 65:251-260
We describe here two strategies to produce biologically active chemokines with authentic N-terminal amino acid residues. The first involves producing the target chemokine with an N-terminal 6×His-SUMO tag in Escherichia coli as inclusion bodies. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951418dee127686dd1f484c032678731
https://doi.org/10.1016/j.pep.2009.01.017
https://doi.org/10.1016/j.pep.2009.01.017
Autor:
Quinn Lu, Robert S. Ames
Publikováno v:
Expert Opinion on Drug Discovery. 4:243-256
Adenovirus, retrovirus and lentivirus-based vectors, originally engineered and optimized for in vivo and ex vivo gene therapy, have become increasingly useful for viral-mediated gene delivery to support in vitro cell-based assays. Viral vectors under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::750446c7a7d1e999bd68c4ea458d70a0
https://doi.org/10.1517/17460440902751599
https://doi.org/10.1517/17460440902751599
Publikováno v:
Expert Opinion on Drug Discovery. 2:1669-1681
The recombinant baculovirus/insect cell system was firmly established as a leading method for recombinant protein production when a new potential use for these viruses was revealed in 1995. It was reported that engineered recombinant baculoviruses co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba4c688c7ff04b13a5ffe703ecb39bb
https://doi.org/10.1517/17460441.2.12.1669
https://doi.org/10.1517/17460441.2.12.1669
Autor:
William E. Wixted, Yolanda Sanchez, Wensheng Xie, Yan Liu, Roberto Solari, Hu Li, Nilesh Chitnis, James F. Callahan, Alan J. Diehl, Christina S. Pao, Maggie Truong, James A. Fornwald, Robert S. Ames, Marie Pariollaud
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119738 (2015)
PLoS ONE
PLoS ONE
Endoplasmic reticulum stress plays a critical role to restore the homeostasis of protein production in eukaryotic cells. This vital process is hence involved in many types of diseases including COPD. PERK, one branch in the ER stress signaling pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8da42850efe895461fb0e79d7caf7b6
http://hdl.handle.net/10044/1/54073
http://hdl.handle.net/10044/1/54073
Autor:
Henry M. Sarau, Valeria Camarda, Stephen A. Douglas, Girolamo Calo, David G. Lambert, Nambi Aiyar, Robert N. Willette, Dulcie B. Schmidt, Parvathi Nuthulaganti, Gerald Stankus, Christopher P. Doe, David J. Behm, James J. Foley, James A. Fornwald, Robert S. Ames
Publikováno v:
British Journal of Pharmacology. 148:173-190
Several peptidic urotensin-II (UT) receptor antagonists exert 'paradoxical' agonist activity in recombinant cell- and tissue-based bioassay systems, likely the result of differential urotensin-II receptor (UT receptor) signal transduction/coupling ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4be855e96b51b4b74e5c2a722847fd95
https://doi.org/10.1038/sj.bjp.0706716
https://doi.org/10.1038/sj.bjp.0706716