Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Robert Roskoski"'
Autor:
Robert Roskoski Jr.
Publikováno v:
Pharmacological Research, Vol 209, Iss , Pp 107465- (2024)
Lung cancer is the leading cause of cancer deaths in the United States and the world. It is divided into two major types: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). In the tumor-node-metastasis (TNM) cancer-staging classifi
Externí odkaz:
https://doaj.org/article/1098f4c94b314deb9702a8bdf2335bd8
Autor:
Robert Roskoski, Jr.
Publikováno v:
Pharmacological Research, Vol 203, Iss , Pp 107181- (2024)
Kidney cancers comprise about 3% of all new malignancies in the United States. Renal cell carcinomas (RCCs) are the most common type of renal malignancy making up about 85% of kidney cancer cases. Signs and symptoms of renal cell carcinomas can resul
Externí odkaz:
https://doaj.org/article/df61a1d164a24d3c9532c1938e622b44
Autor:
Robert Roskoski, Jr.
Publikováno v:
Pharmacological Research, Vol 200, Iss , Pp 107059- (2024)
Owing to the dysregulation of protein kinase activity in many diseases including cancer, this enzyme family has become one of the most important drug targets in the 21st century. There are 80 FDA-approved therapeutic agents that target about two doze
Externí odkaz:
https://doaj.org/article/37a596467db74f7cab452973739ae8d5
Autor:
Robert Roskoski, Jr.
Publikováno v:
Pharmacological Research, Vol 199, Iss , Pp 107036- (2024)
Because genetic alterations including mutations, overexpression, translocations, and dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this enzyme family is the target of many drug discovery programs worldwide. The
Externí odkaz:
https://doaj.org/article/5022257c3ffa4ebcb2cc02ce3699567b
Autor:
Robert Roskoski Jr.
Publikováno v:
Pharmacological Research, Vol 194, Iss , Pp 106847- (2023)
Owing to genetic alterations and overexpression, the dysregulation of protein kinases plays a significant role in the pathogenesis of many autoimmune and neoplastic disorders and protein kinase antagonists have become an important drug target. Althou
Externí odkaz:
https://doaj.org/article/6a816da400b14d8fb6032c3e46c8f1b6
Autor:
Robert Roskoski, Jr.
Publikováno v:
Pharmacological Research, Vol 191, Iss , Pp 106774- (2023)
Because genetic alterations including mutations, overexpression, translocations, and dysregulation of protein kinases are involved in the pathogenesis of many illnesses, this enzyme family is the target of many drug discovery programs in the pharmace
Externí odkaz:
https://doaj.org/article/dc98d3078f1b4bef841fad25cdca6d3c
Autor:
Robert Roskoski, Jr.
Publikováno v:
Pharmacological Research, Vol 189, Iss , Pp 106642- (2023)
Psoriasis is a heterogeneous, inflammatory, autoimmune skin disease that affects up to 2% of the world’s population. There are many treatment modalities including topical medicines, ultraviolet light therapy, monoclonal antibodies, and several oral
Externí odkaz:
https://doaj.org/article/d485b7feeef94ec88650877780571a08
Autor:
Robert Roskoski, Jr.
Publikováno v:
Pharmacological Research, Vol 183, Iss , Pp 106362- (2022)
The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that interacts with and regulates the activity
Externí odkaz:
https://doaj.org/article/493dd4a1284d4cd48cf221006d84aa90
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233367 (2020)
Total NIH funding dollars have increased from 2009-2018. We questioned whether this growth has occurred proportionately around the country and throughout allopathic medical schools. Therefore, we compared the trend in NIH grant funding from 2009 to 2
Externí odkaz:
https://doaj.org/article/764d5c6fd1a54544bb9c8dda1b1b713c
Autor:
Robert, Roskoski
Publikováno v:
Academic Medicine. 98:67-74
To examine trends in National Institutes of Health (NIH) funding to U.S. medical schools and their academic departments and the amount of awards provided by each of the NIH institutes.All data on NIH awards to U.S. medical schools from 2000 to 2020 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef60f2762a3f25bd1a1f997f59656cbc
https://doi.org/10.1097/acm.0000000000004959
https://doi.org/10.1097/acm.0000000000004959