Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Robert Romano"'
Autor:
Feria A. Ladha, Ketan Thakar, Anthony M. Pettinato, Nicholas Legere, Shahnaz Ghahremani, Rachel Cohn, Robert Romano, Emily Meredith, Yu-Sheng Chen, J. Travis Hinson
Publikováno v:
Cell Reports, Vol 36, Iss 6, Pp 109512- (2021)
Summary: Actinins are strain-sensing actin cross-linkers that are ubiquitously expressed and harbor mutations in human diseases. We utilize CRISPR, pluripotent stem cells, and BioID to study actinin interactomes in human cardiomyocytes. We identify 3
Externí odkaz:
https://doaj.org/article/e6307fe6bca2447b9447356fa2b7a8c9
Autor:
Rachel Cohn, Ketan Thakar, Andre Lowe, Feria A. Ladha, Anthony M. Pettinato, Robert Romano, Emily Meredith, Yu-Sheng Chen, Katherine Atamanuk, Bryan D. Huey, J. Travis Hinson
Publikováno v:
Stem Cell Reports, Vol 12, Iss 1, Pp 71-83 (2019)
Summary: Thick-filament sarcomere mutations are a common cause of hypertrophic cardiomyopathy (HCM), a disorder of heart muscle thickening associated with sudden cardiac death and heart failure, with unclear mechanisms. We engineered four isogenic in
Externí odkaz:
https://doaj.org/article/5859d4a741e64ad684d268f581623897
Autor:
Anthony M. Pettinato, Dasom Yoo, Jennifer VanOudenhove, Yu-Sheng Chen, Rachel Cohn, Feria A. Ladha, Xiulan Yang, Ketan Thakar, Robert Romano, Nicolas Legere, Emily Meredith, Paul Robson, Michael Regnier, Justin L. Cotney, Charles E. Murry, J. Travis Hinson
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109088- (2021)
Summary: Human cardiac regeneration is limited by low cardiomyocyte replicative rates and progressive polyploidization by unclear mechanisms. To study this process, we engineer a human cardiomyocyte model to track replication and polyploidization usi
Externí odkaz:
https://doaj.org/article/847db9f1ea284d26af489605c9dc05dc
Autor:
Robert Romano, Shahnaz Ghahremani, Talia Zimmerman, Nicholas Legere, Ketan Thakar, Feria A. Ladha, Anthony M. Pettinato, J. Travis Hinson
Publikováno v:
Circulation
Background: Titin truncation variants (TTNtvs) are the most common inheritable risk factor for dilated cardiomyopathy (DCM), a disease with high morbidity and mortality. The pathogenicity of TTNtvs has been associated with structural localization as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6a8a02cf152562ad5202cef1e2739e8
https://doi.org/10.1161/circulationaha.120.049997
https://doi.org/10.1161/circulationaha.120.049997
Autor:
Robert Romano, Ketan Thakar, David J. Mellert, Anthony M. Pettinato, J. Travis Hinson, Nicholas Legere, Rachel Cohn, Yu-Sheng Chen, Feria A. Ladha
Publikováno v:
Circulation
Background: Pathogenic TNNT2 variants are a cause of hypertrophic and dilated cardiomyopathies, which promote heart failure by incompletely understood mechanisms. The precise functional significance for 87% of TNNT2 variants remains undetermined, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2617806be21e2987e10562992f2b0500
https://doi.org/10.1161/circulationaha.120.047999
https://doi.org/10.1161/circulationaha.120.047999
Autor:
Timothy F. Witham, Debraj Mukherjee, Stacey Q Wolfe, Robert Romano, Adrian E. Jimenez, Judy Huang, Adham M. Khalafallah, Lola B. Chambless
Publikováno v:
World neurosurgery. 154
Objective The novel coronavirus disease 2019 (COVID-19) pandemic has led to a shift to virtual residency interviews for the 2020–2021 neurosurgery match, with unknown implications for stakeholders. This study seeks to analyze the perceptions of res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4002cdeebcdbefd55881b1cbde531ee4
https://pubmed.ncbi.nlm.nih.gov/34363998
https://pubmed.ncbi.nlm.nih.gov/34363998
Autor:
Jessica Costa-Guda, Robert Romano, Samip Shah, Kristin R. Corrado, Madison Rose, Justin Bellizzi, Elizabeth A. Saria, Sanjay M. Mallya, Andrew Arnold, Kirsten Saucier, Cynthia B Alander
Publikováno v:
Endocrinology
The protein product of the cyclin D1 oncogene functions by activating partner cyclin-dependent kinases (cdk)4 or cdk6 to phosphorylate, thereby inactivating, the retinoblastoma protein pRB. Nonclassical, cdk-independent, functions of cyclin D1 have b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a6f6e581f9f74f4492130ddf45abb61
https://doi.org/10.1210/endocr/bqaa159
https://doi.org/10.1210/endocr/bqaa159
Autor:
Nicholas Legere, Rachel Cohn, David J. Mellert, Anthony M. Pettinato, John T. Hinson, Ketan Thakar, Robert Romano, Yu-Sheng Chen, Feria A. Ladha
Publikováno v:
Circulation Research. 127
Sarcomere gene mutations are the most common inheritable risk factor for heart failure, a disease with high morbidity and mortality, yet the pathogenicity of a large proportion of sarcomere gene variants remains unknown. The knowledge of which and ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a973f13734b072e5195da3b2ffea153
https://doi.org/10.1161/res.127.suppl_1.mp100
https://doi.org/10.1161/res.127.suppl_1.mp100
Autor:
Robert Romano, John T. Hinson, Ketan Thakar, Anthony M. Pettinato, Rachel Cohn, Feria A. Ladha, Emily Meredith, Nick Legere, Yu-Sheng Chen
Publikováno v:
Circulation Research. 127
The cardiac sarcomere is a multiprotein complex that generates pulsatile contractile force, enabling the heart to circulate vital nutrients, but its molecular components and dynamic interactions are incompletely understood. Cardiac alpha-actinin-2 (e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ddc98e7019af6649399b71be4be043e
https://doi.org/10.1161/res.127.suppl_1.273
https://doi.org/10.1161/res.127.suppl_1.273
Autor:
Rachel Cohn, John T. Hinson, Nicolas Legere, Feria A. Ladha, Yu-Sheng Chen, Robert Romano, Emily Meredith, Ketan Thakar, Anthony M. Pettinato
RationaleActinins are actin cross-linkers that are ubiquitously expressed and harbor mutations in heritable diseases. The predominant cardiac actinin is encoded by ACTN2, which is a core structural component of the sarcomere Z-disk. ACTN2 is required
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ec22a00804b9cac4662cec937b10ba
https://doi.org/10.1101/2020.03.18.994004
https://doi.org/10.1101/2020.03.18.994004
