Zobrazeno 1 - 10 of 60 pro vyhledávání: '"Robert Reinhardt"'
1
Akademický článek
Visualisation of gene expression within the context of tissues using an X-ray computed tomography-based multimodal approach
Autor: Kristaps Kairišs, Natalia Sokolova, Lucie Zilova, Christina Schlagheck, Robert Reinhardt, Tilo Baumbach, Tomáš Faragó, Thomas van de Kamp, Joachim Wittbrodt, Venera Weinhardt
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract The development of an organism is orchestrated by the spatial and temporal expression of genes. Accurate visualisation of gene expression patterns in the context of the surrounding tissues offers a glimpse into the mechanisms that drive morp
Externí odkaz: https://doaj.org/article/a82da212777549298f15fd4846e6cadb
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2
Akademický článek
Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity
Autor: Jonas Malkmus, Laurène Ramos Martins, Shalu Jhanwar, Bonnie Kircher, Victorio Palacio, Rushikesh Sheth, Francisca Leal, Amandine Duchesne, Javier Lopez-Rios, Kevin A. Peterson, Robert Reinhardt, Koh Onimaru, Martin J. Cohn, Aimée Zuniga, Rolf Zeller
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit
Externí odkaz: https://doaj.org/article/8daa3afd4ca340eaad289f8348f3805b
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3
Akademický článek
Ontogenic Identification and Analysis of Mesenchymal Stromal Cell Populations during Mouse Limb and Long Bone Development
Autor: Gretel Nusspaumer, Sumit Jaiswal, Andrea Barbero, Robert Reinhardt, Dana Ishay Ronen, Alexander Haumer, Thomas Lufkin, Ivan Martin, Rolf Zeller
Publikováno v: Stem Cell Reports, Vol 9, Iss 4, Pp 1124-1138 (2017)
Bone-derived mesenchymal stromal cells (MSCs) differentiate into multiple lineages including chondro- and osteogenic fates and function in establishing the hematopoietic compartment of the bone marrow. Here, we analyze the emergence of different MSC
Externí odkaz: https://doaj.org/article/a21df5e4da304510bb3ca0b6ad018ab9
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4
Akademický článek
Polymorphism in Commercial Sources of Fusidic Acid: A Comparative Study of the In Vitro Release Characteristics of Forms I and III from a Marketed Pharmaceutical Cream
Autor: Jonathan Byrne, Robert Reinhardt, Trinidad Velasco-Torrijos
Publikováno v: Journal of Analytical Methods in Chemistry, Vol 2017 (2017)
A comparison of the polymorphic forms of 3 commercial sources of fusidic acid using FTIR and XRPD techniques has been performed in this study. It has been demonstrated that polymorphic Forms I and III are currently available on the commercial market.
Externí odkaz: https://doaj.org/article/1df2cddf60da4a7faef78055eeb583f9
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5
Akademický článek
Handling Permutation in Sequence Comparison: Genome-Wide Enhancer Prediction in Vertebrates by a Novel Non-Linear Alignment Scoring Principle.
Autor: Dirk Dolle, Juan L Mateo, Michael P Eichenlaub, Rebecca Sinn, Robert Reinhardt, Burkhard Höckendorf, Daigo Inoue, Lazaro Centanin, Laurence Ettwiller, Joachim Wittbrodt
Publikováno v: PLoS ONE, Vol 10, Iss 10, p e0141487 (2015)
Enhancers have been described to evolve by permutation without changing function. This has posed the problem of how to predict enhancer elements that are hidden from alignment-based approaches due to the loss of co-linearity. Alignment-free algorithm
Externí odkaz: https://doaj.org/article/42738ae3e30b471485d88b5475ae03f0
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10
SMAD4 target genes are part of a transcriptional network that integrates the response to BMP and SHH signaling during early limb bud patterning
Autor: Rolf Zeller, Julie Gamart, Robert Reinhardt, Thomas Oberholzer, Frédéric Laurent, Aimée Zuniga, Iros Barozzi, Laurène Ramos Martins, Axel Visel
Publikováno v: Development (Cambridge, England), vol 148, iss 23
Development (Cambridge, England)
article-version (VoR) Version of Record
Development
SMAD4 regulates gene expression in response to BMP and TGFβ signal transduction, and is required for diverse morphogenetic processes, but its target genes have remained largely elusive. Here, we identify the SMAD4 target genes in mouse limb buds usi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d676506e583373e9d8e92abd208b1c5
https://escholarship.org/uc/item/47k5k30b
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