Zobrazeno 1 - 10 of 26 pro vyhledávání: '"Robert Rehmann"'
1
Akademický článek
Muscle diffusion MRI reveals autophagic buildup in a mouse model for Pompe disease
Autor: Marlena Rohm, Gabriele Russo, Xavier Helluy, Martijn Froeling, Vincent Umathum, Nicolina Südkamp, Denise Manahan-Vaughan, Robert Rehmann, Johannes Forsting, Frank Jacobsen, Andreas Roos, Yoon Shin, Anne Schänzer, Matthias Vorgerd, Lara Schlaffke
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Quantitative muscle MRI is increasingly important in the non-invasive evaluation of neuromuscular disorders and their progression. Underlying histopathotological alterations, leading to changes in qMRI parameters are incompletely unraveled.
Externí odkaz: https://doaj.org/article/3bd7a96d0a32465b92df1d3a2ab6a9e5
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3
Akademický článek
Quantitative muscle MRI captures early muscle degeneration in calpainopathy
Autor: Johannes Forsting, Marlena Rohm, Martijn Froeling, Anne-Katrin Güttsches, Nicolina Südkamp, Andreas Roos, Matthias Vorgerd, Lara Schlaffke, Robert Rehmann
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract To evaluate differences in qMRI parameters of muscle diffusion tensor imaging (mDTI), fat-fraction (FF) and water T2 time in leg muscles of calpainopathy patients (LGMD R1/D4) compared to healthy controls, to correlate those findings to clin
Externí odkaz: https://doaj.org/article/815aa00d380b4a2f959745644e150855
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4
Akademický článek
Dysregulation of Metabolism and Proteostasis in Skeletal Muscle of a Presymptomatic Pompe Mouse Model
Autor: Marlena Rohm, Leon Volke, Lara Schlaffke, Robert Rehmann, Nicolina Südkamp, Andreas Roos, Anne Schänzer, Andreas Hentschel, Matthias Vorgerd
Publikováno v: Cells, Vol 12, Iss 12, p 1602 (2023)
Pompe disease is a rare genetic metabolic disorder caused by mutations in acid-alpha glucoside (GAA) leading to pathological lysosomal glycogen accumulation associated with skeletal muscle weakness, respiratory difficulties and cardiomyopathy, depend
Externí odkaz: https://doaj.org/article/7a6e8d90f5014814bf8c059a78c72fa0
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5
Akademický článek
3D Automated Segmentation of Lower Leg Muscles Using Machine Learning on a Heterogeneous Dataset
Autor: Marlena Rohm, Marius Markmann, Johannes Forsting, Robert Rehmann, Martijn Froeling, Lara Schlaffke
Publikováno v: Diagnostics, Vol 11, Iss 10, p 1747 (2021)
Quantitative MRI combines non-invasive imaging techniques to reveal alterations in muscle pathophysiology. Creating muscle-specific labels manually is time consuming and requires an experienced examiner. Semi-automatic and fully automatic methods red
Externí odkaz: https://doaj.org/article/8d9a33858eac4fb8af984826d3995dbb
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6
Akademický článek
High Inter-Rater Reliability of Manual Segmentation and Volume-Based Tractography in Healthy and Dystrophic Human Calf Muscle
Autor: Johannes Forsting, Marlena Rohm, Martijn Froeling, Anne-Katrin Güttsches, Matthias Vorgerd, Lara Schlaffke, Robert Rehmann
Publikováno v: Diagnostics, Vol 11, Iss 9, p 1521 (2021)
Background: Muscle diffusion tensor imaging (mDTI) is a promising surrogate biomarker in the evaluation of muscular injuries and neuromuscular diseases. Since mDTI metrics are known to vary between different muscles, separation of different muscles i
Externí odkaz: https://doaj.org/article/de87a20f8d334a01bafc4a3bdd8613eb
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7
Akademický článek
Muscle imaging data in late-onset Pompe disease reveal a correlation between the pre-existing degree of lipomatous muscle alterations and the efficacy of long-term enzyme replacement therapy
Autor: Kai Michael Gruhn, Christoph Malte Heyer, Anne-Katrin Güttsches, Robert Rehmann, Volkmar Nicolas, Tobias Schmidt-Wilcke, Martin Tegenthoff, Matthias Vorgerd, Rudolf Andre Kley
Publikováno v: Molecular Genetics and Metabolism Reports, Vol 3, Iss C, Pp 58-64 (2015)
Background: Late-onset Pompe disease (LOPD) is a metabolic myopathy caused by mutations in GAA and characterized by proximal muscle weakness and respiratory insufficiency. There is evidence from clinical studies that enzyme replacement therapy (ERT)
Externí odkaz: https://doaj.org/article/fcbcd21b4c69453bb9b6cfb1c2b57310
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8
Dysregulation of Metabolism and Proteostasis in Skeletal Muscle of a Presymptomatic Pompe Mouse Model
Autor: Vorgerd, Marlena Rohm, Leon Volke, Lara Schlaffke, Robert Rehmann, Nicolina Südkamp, Andreas Roos, Anne Schänzer, Andreas Hentschel, Matthias
Publikováno v: Cells; Volume 12; Issue 12; Pages: 1602
Pompe disease is a rare genetic metabolic disorder caused by mutations in acid-alpha glucoside (GAA) leading to pathological lysosomal glycogen accumulation associated with skeletal muscle weakness, respiratory difficulties and cardiomyopathy, depend
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::6a1260ea1b80cfd997e27d4b55267638
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9
Quantitative muscle MRI displays clinically relevant myostructural abnormalities in long-term ICU-survivors: a case–control study
Autor: Robert Rehmann, Elena Enax-Krumova, Christine Meyer-Friessem, Lara Schlaffke
Publikováno v: BMC Medical Imaging. 23
Background Long-term data on ICU-survivors reveal persisting sequalae and a reduced quality-of-life even after years. Major complaints are neuromuscular dysfunction due to Intensive care unit acquired weakness (ICUAW). Quantitative MRI (qMRI) protoco
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f68f4b528dea1dfe1eb50ce45295e82
https://doi.org/10.1186/s12880-023-00995-7
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