Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Robert Rauscher"'
Publikováno v:
Non-Coding RNA, Vol 7, Iss 4, p 73 (2021)
Protein biosynthesis is essential for any organism, yet how this process is regulated is not fully understood at the molecular level. During evolution, ribosomal RNA expanded in specific regions, referred to as rRNA expansion segments (ES). First fun
Externí odkaz:
https://doaj.org/article/e743399f51a04e52ab8fffe472d2a0ea
Autor:
Sebastian Kirchner, Zhiwei Cai, Robert Rauscher, Nicolai Kastelic, Melanie Anding, Andreas Czech, Bertrand Kleizen, Lynda S Ostedgaard, Ineke Braakman, David N Sheppard, Zoya Ignatova
Publikováno v:
PLoS Biology, Vol 15, Iss 5, p e2000779 (2017)
Synonymous single nucleotide polymorphisms (sSNPs) are considered neutral for protein function, as by definition they exchange only codons, not amino acids. We identified an sSNP that modifies the local translation speed of the cystic fibrosis transm
Externí odkaz:
https://doaj.org/article/89ad557e9e7d489bb7580184eb1c0d23
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-10 (2013)
Abstract The genetic code is degenerate; thus, protein evolution does not uniquely determine the coding sequence. One of the puzzles in evolutionary genetics is therefore to uncover evolutionary driving forces that result in specific codon choice. In
Externí odkaz:
https://doaj.org/article/9e69abfa1da34d9080667dcd9cbaca60
Autor:
Hugo R. de Jonge, Zoya Ignatova, Eric J. Sorscher, Raymond A. Frizzell, Johannes Wagner, Robert Rauscher, Giovana B Bampi, Kathryn E. Oliver, Leonardo A. Santos, Sebastian Kirchner, Marcel J. C. Bijvelds
Publikováno v:
Journal of Cystic Fibrosis, 19(6), 1021-1026. Elsevier
J Cyst Fibros
J Cyst Fibros
BACKGROUND: Chronic inflammation is a hallmark among patients with cystic fibrosis (CF). We explored whether mutation-induced (F508del) misfolding of the cystic fibrosis transmembrane conductance regulator (CFTR), and/or secondary colonization with o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2de7f2c39e49eb0d55d88033691491
https://doi.org/10.1016/j.jcf.2020.04.005
https://doi.org/10.1016/j.jcf.2020.04.005
Autor:
Disha Joshi, Manfred Ballmann, Lisa J. Strug, Kathryn E. Oliver, Eric J. Sorscher, Robert Rauscher, Marta Guevara-Ferrer, Giovana B Bampi, Zoya Ignatova, David Mark, Johanna M. Rommens, Leonardo A. Santos
Publikováno v:
Proc Natl Acad Sci U S A
Epistasis refers to the dependence of a mutation on other mutation(s) and the genetic context in general. In the context of human disorders, epistasis complicates the spectrum of disease symptoms and has been proposed as a major contributor to variat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b3fdb5de8ae0182243dc0e56ce26ca
https://doi.org/10.1073/pnas.2010612118
https://doi.org/10.1073/pnas.2010612118
Autor:
Robert Rauscher, D. Joshi, Giovana B Bampi, L. Strug, M. Ballman, M. Ferrer, Eric J. Sorscher, Kathryn E. Oliver, J. Rommens, D. Mark, Zoya Ignatova
Publikováno v:
Journal of Cystic Fibrosis. 20:S308
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6219d4014a6e871f3d6287c8446cc51
https://doi.org/10.1016/s1569-1993(21)02072-5
https://doi.org/10.1016/s1569-1993(21)02072-5
Autor:
Robert Rauscher, Zoya Ignatova
Publikováno v:
Biochemical Society transactions. 46(4)
Ribosomes translate mRNAs with non-uniform speed. Translation velocity patterns are a conserved feature of mRNA and have evolved to fine-tune protein folding, expression and function. Synonymous single-nucleotide polymorphisms (sSNPs) that alter prog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0800055c23c6c3f3f195b00416bc2559
https://pubmed.ncbi.nlm.nih.gov/30065107
https://pubmed.ncbi.nlm.nih.gov/30065107
Autor:
Robert Rauscher, Zoya Ignatova
Publikováno v:
Biochemical Society Transactions. 43:1247-1252
In multicellular organisms, the epithelia is a contact surface with the surrounding environment and is exposed to a variety of adverse biotic (pathogenic) and abiotic (chemical) factors. Multi-layered pathways that operate on different time scales ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed8f6a77b98470433932a7ad5288a00
https://doi.org/10.1042/bst20150166
https://doi.org/10.1042/bst20150166
Autor:
Sebastian Kirchner, not provided Robert Rauscher, not provided Andreas Czech, not provided Zoya Ignatova
This protocol describes the knock-down of specific tRNA(s) in mammalian cells using short hairpin RNA (shRNA)-based RNA interference (RNAi). We have used this method successfully to silence specific tRNAs in in HeLa1 and N2a cells2. References 1. Kir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3106ba8874f262212e108d44be97154
https://doi.org/10.17504/protocols.io.hgfb3tn
https://doi.org/10.17504/protocols.io.hgfb3tn
Autor:
Sebastian Kirchner, not provided Robert Rauscher, not provided Andreas Czech, not provided Zoya Ignatova
This protocol describes the microarray-based quantification of human tRNAs. The tRNA microarray consists of 40 full-length tDNA probes recognising all 54 nuclearly encoded human isoacceptor tRNAs1. The array has been shown to reliably distinguish tRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c47271005b40bb0d800121ff18d28af
https://doi.org/10.17504/protocols.io.hfcb3iw
https://doi.org/10.17504/protocols.io.hfcb3iw