Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Robert Ramm"'
Autor:
Jonas Thom, Nathalie Roters, Slavica Schuemann, Birgit Andrée, Falk F. R. Buettner, Andres Hilfiker, Tobias Goecke, Robert Ramm
Publikováno v:
Biomedicines, Vol 12, Iss 7, p 1470 (2024)
Background: Patterns of humoral immune responses represent a major hurdle in terms of pig-to-human xenotransplantation approaches. The best-known xenogeneic glycan antigens present in pigs are the αGal (Galili antigen) and the non-human sialic acid
Externí odkaz:
https://doaj.org/article/ac7cdb9cb16b4f9abf67ce74402dff19
Autor:
Firdavs Oripov, Robert Ramm, Christine Falk, Tobias Goecke, Johannes Ebken, Ramadan Jashari, Dietmar Böthig, Alexander Horke, Murat Avsar, Dmitry Bobylev, Axel Haverich, Andres Hilfiker, Samir Sarikouch
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
ObjectivesDecellularized homograft valves (DHV) appear to elicit an immune response despite efficient donor cell removal.Materials and methodsA semiquantitative Dot-Blot analysis for preformed and new recipient antibodies was carried out in 20 patien
Externí odkaz:
https://doaj.org/article/60a1df0ca9eb4d0b98e84d347b6cf8b8
Autor:
Dmitry Bobylev, Axel Haverich, Johannes Ebken, Andres Hilfiker, Tobias Goecke, Murat Avsar, Samir Sarikouch, Nils Mester, Dietmar Böthig, Ramadan Jashari, Alexander Horke, Serghei Cebotari, Isabel Smart, Robert Ramm, Igor Tudorache
Publikováno v:
European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
OBJECTIVES Decellularized homograft valves (DHVs) have shown promising clinical results, particularly in the treatment of congenital heart disease. However, DHV appears to elicit an immune response in a subset of young patients, indicated by early va
Autor:
Igor Tudorache, Friederike Bothe, Samir Sarikouch, Anatol Ciubotaru, Klaus Höffler, Tobias Goecke, Björn Petersen, Peter Köhler, Axel Haverich, Heiner Niemann, Serghei Cebotari, Andres Hilfiker, Robert Ramm
Publikováno v:
Regen Biomater
Decellularization of xenogeneic heart valves might lead to excellent regenerative implants, from which many patients could benefit. However, this material carries various xenogeneic epitopes and thus bears a considerable inherent immunological risk.
Autor:
Katja Findeisen, Robert Ramm, Axel Haverich, Louisa Kolbeck, Hans-Klaus Höffler, Lucrezia Morticelli, Andres Hilfiker, Gudrun Brandes, Sotirios Korossis, Tobias Goecke
Publikováno v:
Xenotransplantation. 27
The use of decellularized xenogeneic heart valves might offer a solution to overcome the issue of human valve shortage. The aim of this study was to revise decellularization protocols in combination with enzymatic deglycosylation, in order to reduce
Autor:
Robert Ramm, Doreen Lenz, Heiner Niemann, Björn Petersen, Axel Haverich, Tobias Goecke, Isabel Smart, Andres Hilfiker
Publikováno v:
XenotransplantationREFERENCES. 28(1)
Background The present study reports the development of a sensitive dot blot protocol for determining the level of preformed antibodies against porcine heart valve tissue derived from wild‐type (WT) and α‐Gal‐KO (GGTA1‐KO) pigs in human sera
Autor:
Samir Sarikouch, Andres Hilfiker, I. Ralle, J. Ebken, Alexander Horke, N. Mester, Robert Ramm, Tobias Goecke, Axel Haverich
Publikováno v:
The Thoracic and Cardiovascular Surgeon.
Publikováno v:
Xenotransplantation, 27(2):e12565
BACKGROUND: Decellularized human pulmonary heart valve (dhHV) scaffolds have been shown to be the gold standard especially for younger, adolescent patients. However, human heart valves are limited in availability. Xenogeneic decellularized pig heart
Autor:
Axel Haverich, Karolina Theodoridis, Katja Findeisen, Andres Hilfiker, Sotirios Korossis, Robert Ramm, Birgit Andrée, Janina Müller
Publikováno v:
Acta Biomaterialia. 43:71-77
Non-fixed, decellularized allogeneic heart valve scaffolds seem to be the best choice for heart valve replacement, their availability, however, is quite limited. Cryopreservation could prolong their shelf-life, allowing for their ideal match to a rec
Autor:
Katja Findeisen, Axel Haverich, Klaus Hoeffler, Samir Sarikouch, Karolina Theodoridis, Robert Ramm, Tobias Goecke, Igor Tudorache, Serghei Cebotari, Andres Hilfiker, Anatol Ciubotaru
Publikováno v:
XenotransplantationREFERENCES. 27(2)
Background Limited availability of decellularized allogeneic heart valve substitutes restricts the clinical application thereof. Decellularized xenogeneic valves might constitute an attractive alternative; however, increased immunological hurdles hav