Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Robert Radinsky"'
Autor:
Michael J. Boedigheimer, Daniel J. Freeman, Panteha Kiaei, Michael A. Damore, Robert Radinsky
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 2, Pp 125-132 (2013)
Background Epidermal growth factor receptor (EGFR)-targeted agents have demonstrated clinical benefit in patients with cancer. Identifying tissue-of-origin-independent predictive biomarkers is important to optimally treat patients. We sought to ident
Externí odkaz:
https://doaj.org/article/a3e3b8b14754452280b834422ca755f5
Publikováno v:
Sarcoma, Vol 1, Iss 1, Pp 23-29 (1997)
Purpose. MDM2 is an oncogene whose protein product may promote tumorigenesis by blocking wild-type p53 tumor suppressor mediated G0/G1 cell cycle arrest, thereby inhibiting repair of damaged DNA prior to cell division. While MDM2 DNA amplification i
Externí odkaz:
https://doaj.org/article/379a5358f83640669f3d8ccbc0f03a35
Autor:
Frank J Calzone, Elaina Cajulis, Young-Ah Chung, Mei-Mei Tsai, Petia Mitchell, John Lu, Ching Chen, Jilin Sun, Robert Radinsky, Richard Kendall, Pedro J Beltran
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e55135 (2013)
BACKGROUND: Therapeutic antibodies targeting the IGF1R have shown diverse efficacy and safety signals in oncology clinical trials. The success of these agents as future human therapeutics depends on understanding the specific mechanisms by which thes
Externí odkaz:
https://doaj.org/article/37585a74733447af89a14099bfcb889d
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
Supplementary methods of tumor xenograft studies and light microscopic evaluation of tumor xenografts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809519f7573d2d85599f5e08e9814dd8
https://doi.org/10.1158/1535-7163.22507701
https://doi.org/10.1158/1535-7163.22507701
Autor:
Robert Radinsky, Angela Coxon, Jonathan D. Oliner, Richard Kendall, Stephen Kaufman, David Cordover, Jing Zhou, Ada Chen, Lixia Jin, Qiuping Ye, John Eksterowicz, Dongyin Yu, Rebecca Robertson, Anne Y. Saiki, Steven H. Olson, Tao Osgood, Jude Canon
Supplemental Figure 2. AMG 232 treatment causes p53 stabilization, and increased p21 and MDM2 proteins in p53 wild-type cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09ec4ed1227e54787b7b9b848e7054f8
https://doi.org/10.1158/1535-7163.22502251
https://doi.org/10.1158/1535-7163.22502251
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
AMG 337 KINOME scan binding data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ce3cdee7da5472faad9adbf13ac723
https://doi.org/10.1158/1535-7163.22507716
https://doi.org/10.1158/1535-7163.22507716
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
Tumor cell line profiling data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d19fcb3c43643eae23c6970fc140e93
https://doi.org/10.1158/1535-7163.22507713.v1
https://doi.org/10.1158/1535-7163.22507713.v1
Autor:
Robert Radinsky, Angela Coxon, Jonathan D. Oliner, Richard Kendall, Stephen Kaufman, David Cordover, Jing Zhou, Ada Chen, Lixia Jin, Qiuping Ye, John Eksterowicz, Dongyin Yu, Rebecca Robertson, Anne Y. Saiki, Steven H. Olson, Tao Osgood, Jude Canon
Supplemental Figure 3. Body weights of mice in xenograft efficacy studies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70094c78459d3b06c7a39847cc4f95b7
https://doi.org/10.1158/1535-7163.22502248
https://doi.org/10.1158/1535-7163.22502248
Autor:
Angela Coxon, Isabelle Dussault, Richard Kendall, Robert Radinsky, Jean-Christophe Harmange, Deborah M. Choquette, Daniel Baker, Michael A. Damore, Jonathan Werner, Jodi Moriguchi, Paula J. Kaplan-Lefko, Benny Amore, Teresa L. Burgess, Hue T. Kha, Martin A. Broome, Yihong Zhang, Yajing Yang, Sean Caenepeel, Karen Rex, Paul E. Hughes
The MET receptor tyrosine kinase is involved in cell growth, survival, and invasion. Clinical studies with small molecule MET inhibitors have shown the role of biomarkers in identifying patients most likely to benefit from MET-targeted therapy. AMG 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0074a6c1183119f6d623235dd01743f
https://doi.org/10.1158/1535-7163.c.6538764
https://doi.org/10.1158/1535-7163.c.6538764
Autor:
Robert Radinsky, Angela Coxon, Jonathan D. Oliner, Richard Kendall, Stephen Kaufman, David Cordover, Jing Zhou, Ada Chen, Lixia Jin, Qiuping Ye, John Eksterowicz, Dongyin Yu, Rebecca Robertson, Anne Y. Saiki, Steven H. Olson, Tao Osgood, Jude Canon
Supplemental Figure 1. AMG 232 chemical structure, and 3-D model of AMG 232 bound to MDM2 protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::237c3d9b93b8489d5f776c2f621275e8
https://doi.org/10.1158/1535-7163.22502254
https://doi.org/10.1158/1535-7163.22502254