Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Robert R. Haines"'
Autor:
Benjamin G. Barwick, Christopher D. Scharer, Ryan J. Martinez, Madeline J. Price, Alexander N. Wein, Robert R. Haines, Alexander P. R. Bally, Jacob E. Kohlmeier, Jeremy M. Boss
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differ
Externí odkaz:
https://doaj.org/article/33af14121bb04d5cbdd45624b424b0e7
Autor:
Yu Yang, Ricard Masia, Yue Ren, Jonathan A Hill, Vito J Palombella, Robert R Haines, Marisella Panduro, James F Mohan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/e97a4eea00494bcd80e074d7a4cbb66a
Publikováno v:
J Immunol
Marginal zone B cells (MZB) are a mature B cell subset that rapidly respond to blood-borne pathogens. Although the transcriptional changes that occur throughout MZB development are known, the corresponding epigenetic changes and epigenetic modifying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::861ac5004f70865a2747052d63571dd3
https://pubmed.ncbi.nlm.nih.gov/31492745
https://pubmed.ncbi.nlm.nih.gov/31492745
Autor:
Robert R. Haines, Christopher D. Scharer, Parimal Majumder, Troy D. Randall, Benjamin G. Barwick, Jeremy M. Boss
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(9)
B cells undergo epigenetic remodeling as they differentiate into antibody-secreting cells. LSD1 is a histone demethylase known to decommission active enhancers and cooperate with the antibody-secreting cell master regulatory transcription factor Blim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bc38e3f20a0fff3875d30ab22d52ac
https://pubmed.ncbi.nlm.nih.gov/30232138
https://pubmed.ncbi.nlm.nih.gov/30232138
Autor:
Alexander N. Wein, Jacob E. Kohlmeier, Jeremy M. Boss, Ryan J. Martinez, Madeline J. Price, Robert R. Haines, Alexander P. R. Bally, Benjamin G. Barwick, Christopher D. Scharer
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
B cells provide humoral immunity by differentiating into antibody-secreting plasma cells, a process that requires cellular division and is linked to DNA hypomethylation. Conversely, little is known about how de novo deposition of DNA methylation affe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736b5009774eec70bd3e8041d863855c
https://doi.org/10.1038/s41467-018-04234-4
https://doi.org/10.1038/s41467-018-04234-4
Autor:
Anna K. Kania, Dillon G. Patterson, Madeline J. Price, Troy D. Randall, Robert R. Haines, Muyao Guo, Jeremy M. Boss, Benjamin G. Barwick, John E. Bradley, Christopher D. Scharer
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 200(3)
Epigenetic remodeling is required during B cell differentiation. However, little is known about the direct functions of epigenetic enzymes in Ab-secreting cells (ASC) in vivo. In this study, we examined ASC differentiation independent of T cell help
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c42a2cd821d51a67cd0c47e854fa8fc
https://pubmed.ncbi.nlm.nih.gov/29288200
https://pubmed.ncbi.nlm.nih.gov/29288200
Autor:
Anthony W. Goering, David P. Labeda, Konstantin A. Tchalukov, Robert R. Haines, Neil L. Kelleher, Jessica C. Albright, William W. Metcalf, Kou San Ju, James R. Doroghazi
Publikováno v:
Nature chemical biology
Actinobacteria encode a wealth of natural product biosynthetic gene clusters (NPGCs), whose systematic study is complicated by numerous repetitive motifs. By combining several metrics we developed a method for global classification of these gene clus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb670eda731cc4b86bd4b2d742ef493
https://doi.org/10.1038/nchembio.1659
https://doi.org/10.1038/nchembio.1659
Autor:
Christopher D. Scharer, Chungwen Wei, Benjamin G. Barwick, Ignacio Sanz, Robert R. Haines, Jeremy M. Boss, Emily L. Blalock
Publikováno v:
Scientific Reports
Biobanking is a widespread practice for storing biological samples for future studies ranging from genotyping to RNA analysis. However, methods that probe the status of the epigenome are lacking. Here, the framework for applying the Assay for Transpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81bab51e18f24a955015414d81e47c12
Autor:
Jay C; University of Manchester, Manchester, UK., Haines R; University of Manchester, Manchester, UK., Katz DS; University of Illinois at Urbana-Champaign, Urbana, USA., Carver JC; University of Alabama, Tuscaloosa, USA., Gesing S; University of Notre Dame, Notre Dame, USA., Brandt SR; Louisiana State University, Louisiana, USA., Howison J; University of Texas at Austin, Austin, USA., Dubey A; Argonne National Laboratory, Argonne, USA., Phillips JC; University of Illinois at Urbana-Champaign, Urbana, USA., Wan H; Pacific Northwest National Laboratory, Richland, USA., Turk MJ; University of Illinois at Urbana-Champaign, Urbana, USA.
Publikováno v:
F1000Research [F1000Res] 2020 Oct 02; Vol. 9, pp. 1192. Date of Electronic Publication: 2020 Oct 02 (Print Publication: 2020).
Autor:
Xu J; 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.; 2School of Biological Sciences, and Maurice Wilkins Centre for Molecular Biodiscovery, Faculty of Science, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand., Patassini S; 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.; 2School of Biological Sciences, and Maurice Wilkins Centre for Molecular Biodiscovery, Faculty of Science, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand., Rustogi N; 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK., Riba-Garcia I; 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK., Hale BD; 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK., Phillips AM; 3Department of Electrical Engineering and Electronics, University of Liverpool, Liverpool, L69 3GJ UK., Waldvogel H; 4Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, 1142 New Zealand., Haines R; 5Research IT, The University of Manchester, Manchester, M13 9PL UK., Bradbury P; 5Research IT, The University of Manchester, Manchester, M13 9PL UK., Stevens A; 6Division of Developmental Biology & Medicine, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, M13 9PL UK., Faull RLM; 4Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, 1142 New Zealand., Dowsey AW; 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.; 7Department of Population Health Sciences and Bristol Veterinary School, Faculty of Health Sciences, University of Bristol, Bristol, BS8 2BN UK., Cooper GJS; 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.; 2School of Biological Sciences, and Maurice Wilkins Centre for Molecular Biodiscovery, Faculty of Science, University of Auckland, Private Bag 92019, Auckland, 1142 New Zealand.; 4Centre for Brain Research, Faculty of Medical and Health Sciences, University of Auckland, Auckland, 1142 New Zealand., Unwin RD; 1Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Sciences Centre, Core Technology Facility (3rd Floor), 46 Grafton Street, Manchester, M13 9NT UK.
Publikováno v:
Communications biology [Commun Biol] 2019 Feb 04; Vol. 2, pp. 43. Date of Electronic Publication: 2019 Feb 04 (Print Publication: 2019).