Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Robert R. Fandrich"'
Autor:
Wattamon Srisakuldee, Barbara E. Nickel, Robert R. Fandrich, Feixong Zhang, Kishore B. S. Pasumarthi, Elissavet Kardami
Publikováno v:
Cells, Vol 10, Iss 10, p 2735 (2021)
Mitochondria, abundant organelles in high energy demand cells such as cardiomyocytes, can determine cell death or survival by regulating the opening of mitochondrial permeability transition pore, mPTP. We addressed the hypothesis that the growth fact
Externí odkaz:
https://doaj.org/article/83041677b27448f7a75c23d078c98b64
Autor:
Peter A. Cattini, Michael P. Czubryt, Davinder S. Jassal, David Cheung, Barbara E. Nickel, Robert R. Fandrich, Elissavet Kardami, Raghu S. Nagalingam, Ian M.C. Dixon, Navid Koleini, Natalie M. Landry
Publikováno v:
Cell and Tissue Research. 385:753-768
Fibroblast growth factor 2 (FGF2), produced as high (Hi-) and low (Lo-) molecular weight isoforms, is implicated in cardiac response to injury. The role of endogenous FGF2 isoforms during chronic stress is not well defined. We investigated the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84604ecee03ebf92d2631fa2b1401a34
https://doi.org/10.1007/s00441-021-03465-0
https://doi.org/10.1007/s00441-021-03465-0
Autor:
Kishore B.S. Pasumarthi, Elissavet Kardami, Feixong Zhang, Barbara E. Nickel, Wattamon Srisakuldee, Robert R. Fandrich
Publikováno v:
Cells
Volume 10
Issue 10
Cells, Vol 10, Iss 2735, p 2735 (2021)
Volume 10
Issue 10
Cells, Vol 10, Iss 2735, p 2735 (2021)
Mitochondria, abundant organelles in high energy demand cells such as cardiomyocytes, can determine cell death or survival by regulating the opening of mitochondrial permeability transition pore, mPTP. We addressed the hypothesis that the growth fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a38d855492533545024e8455a85b2fa
Autor:
Andrea L. Edel, Elissavet Kardami, Robert R. Fandrich, Amir Ravandi, Navid Koleini, Barbara E. Nickel
Publikováno v:
Chemico-Biological Interactions. 303:35-39
Doxorubicin (Dox), a widely used chemotherapy drug, can also cause cardiotoxic effects leading to heart failure. The excessive oxidative stress caused by Dox results in the modification of a variety of cellular molecules, including phospholipids. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0609d55a2b6c4335d44b3bf1c02dd51
https://doi.org/10.1016/j.cbi.2019.01.032
https://doi.org/10.1016/j.cbi.2019.01.032
Autor:
Jon-Jon Santiago, Leslie J McNaughton, Navid Koleini, Xin Ma, Brian Bestvater, Barbara E Nickel, Robert R Fandrich, Jeffrey T Wigle, Darren H Freed, Rakesh C Arora, Elissavet Kardami
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97281 (2014)
Fibroblast growth factor 2 (FGF-2) is a multifunctional protein synthesized as high (Hi-) and low (Lo-) molecular weight isoforms. Studies using rodent models showed that Hi- and Lo-FGF-2 exert distinct biological activities: after myocardial infarct
Externí odkaz:
https://doaj.org/article/644fe2b74d5d462b9f969b28eac24442
Autor:
Ian M.C. Dixon, Thomas W. Meier, Robert R. Fandrich, Krista L. Filomeno, Todd A. Duhamel, Sunil G. Rattan, Elissavet Kardami, Navid Koleini, Sarah J. Foran, Simon C. Meier, Claire F. Meier, Natalie M. Landry
Publikováno v:
Basic Research in Cardiology
We have previously shown that overexpression of SKI, an endogenous TGF-β1 repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also functions independently of SMAD/TGF-β signaling, by activating the Hip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8056941623b3cd6db791b339e12f41a2
https://doi.org/10.1007/s00395-021-00865-9
https://doi.org/10.1007/s00395-021-00865-9
Autor:
Navid, Koleini, Barbara E, Nickel, Raghu S, Nagalingam, Natalie M, Landry, Robert R, Fandrich, David Y C, Cheung, Ian M, Dixon, Michael P, Czubryt, Davinder S, Jassal, Peter A, Cattini, Elissavet, Kardami
Publikováno v:
Cell and tissue research. 385(3)
Fibroblast growth factor 2 (FGF2), produced as high (Hi-) and low (Lo-) molecular weight isoforms, is implicated in cardiac response to injury. The role of endogenous FGF2 isoforms during chronic stress is not well defined. We investigated the effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59e8067b0143dede31da8264751d36a7
https://pubmed.ncbi.nlm.nih.gov/34057573
https://pubmed.ncbi.nlm.nih.gov/34057573
Autor:
Thane G. Maddaford, David C Nelson, Thomas E. Hedley, Mirna N. Chahine, Kim O'Hara, Graham G. Maddaford, Robert R. Fandrich, Marketa Hlavackova, Justin F. Deniset, Grant N. Pierce, Elissavet Kardami, Elena Dibrov
Publikováno v:
Cellular Signalling. 47:44-51
Aim Heat shock protein 60 (Hsp60) is a mediator of stress-induced vascular smooth muscle cell (VSMC) proliferation. This study will determine, first, if the mitochondrial or cytoplasmic localization of Hsp60 is critical to VSMC proliferation and, sec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e83f411b1f3cd4348c88381fe35528bd
https://doi.org/10.1016/j.cellsig.2018.03.011
https://doi.org/10.1016/j.cellsig.2018.03.011
Autor:
Robert R. Fandrich, Elissavet Kardami, Peter A. Cattini, Natalie M. Landry, Raghu S. Nagalingam, Ian M.C. Dixon, Barbara E. Nickel, Navid Koleini, Michael P. Czubryt
Publikováno v:
Circulation Research. 125
Fibroblast growth factor 2 (FGF2) is implicated in normal cardiac development as well as cardiac pathophysiology; however, FGF2 exist as multiple high and low molecular weight isoforms. While endogenous low molecular weight FGF2 (Lo-FGF2) is cardiopr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d0dc812b59050e9afa9d2270e753b0d
https://doi.org/10.1161/res.125.suppl_1.838
https://doi.org/10.1161/res.125.suppl_1.838
Autor:
Sanjiv Dhingra, Robert R. Fandrich, Glen Lester Sequiera, Davinder S. Jassal, Navid Koleini, Jon-Jon Santiago, Lorrie A. Kirshenbaum, Jie Wang, Elissavet Kardami, Barbara E. Nickel, Peter A. Cattini
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 316(2)
Cardiac fibroblast growth factor 2 (FGF2) exerts multiple paracrine activities related to cardiac response to injury. Endogenous FGF2 is composed of a mixture of 70% high- and 30% low-molecular-weight isoforms (Hi-FGF2 and Lo-FGF2, respectivley); alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac63ca947a3aabbabcfc8aa39c7a652
https://pubmed.ncbi.nlm.nih.gov/30412444
https://pubmed.ncbi.nlm.nih.gov/30412444