Zobrazeno 1 - 10 of 303 pro vyhledávání: '"Robert R McWilliams"'
1
Akademický článek
Phase II trial of the IDO pathway inhibitor indoximod plus pembrolizumab for the treatment of patients with advanced melanoma
Autor: Ramses Sadek, Mohammed Milhem, Olivier Rixe, David Munn, Christopher M Smith, Yousef Zakharia, Joseph Drabick, Kenneth F Grossmann, Robert R McWilliams, Montaser F Shaheen, Ravindra Kolhe, Rafal Pacholczyk, Lucinda L Tennant, Eugene P Kennedy, Charles J Link Jr, Nicholas N Vahanian, Jiayi Yu, Steven S Shen, Erik L Brincks, Gabriela R Rossi
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background The indoleamine 2,3-dioxygenase (IDO) pathway is a key counter-regulatory mechanism that, in cancer, is exploited by tumors to evade antitumor immunity. Indoximod is a small-molecule IDO pathway inhibitor that reverses the immunosuppressiv
Externí odkaz: https://doaj.org/article/3e3e02066379461ebd661d3bcc62f60a
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2
Akademický článek
Assessment of clinical outcomes with immune checkpoint inhibitor therapy in melanoma patients with CDKN2A and TP53 pathogenic mutations.
Autor: Thomas T DeLeon, Daniel R Almquist, Benjamin R Kipp, Blake T Langlais, Aaron Mangold, Jennifer L Winters, Heidi E Kosiorek, Richard W Joseph, Roxana S Dronca, Matthew S Block, Robert R McWilliams, Lisa A Kottschade, Kandelaria M Rumilla, Jesse S Voss, Mahesh Seetharam, Aleksandar Sekulic, Svetomir N Markovic, Alan H Bryce
Publikováno v: PLoS ONE, Vol 15, Iss 3, p e0230306 (2020)
BACKGROUND:CDKN2A and TP53 mutations are recurrent events in melanoma, occurring in 13.3% and 15.1% of cases respectively and are associated with poorer outcomes. It is unclear what effect CDKN2A and TP53 mutations have on the clinical outcomes of pa
Externí odkaz: https://doaj.org/article/3927fd1a2b3d44719753600a2b2972b4
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3
Akademický článek
The vitamin D receptor gene as a determinant of survival in pancreatic cancer patients: Genomic analysis and experimental validation.
Autor: Federico Innocenti, Kouros Owzar, Chen Jiang, Amy S Etheridge, Raluca Gordân, Alexander B Sibley, Flora Mulkey, Donna Niedzwiecki, Dylan Glubb, Nicole Neel, Mark S Talamonti, David J Bentrem, Eric Seiser, Jen Jen Yeh, Katherine Van Loon, Howard McLeod, Mark J Ratain, Hedy L Kindler, Alan P Venook, Yusuke Nakamura, Michiaki Kubo, Gloria M Petersen, William R Bamlet, Robert R McWilliams
Publikováno v: PLoS ONE, Vol 13, Iss 8, p e0202272 (2018)
PURPOSE:Advanced pancreatic cancer is a highly refractory disease almost always associated with survival of little more than a year. New interventions based on novel targets are needed. We aim to identify new genetic determinants of overall survival
Externí odkaz: https://doaj.org/article/3e344ee31f6b477ca981d00ace30fd70
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5
Akademický článek
Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for high-risk operable Stage III melanoma: the Phase II NeoACTIVATE trial
Autor: Tina J. Hieken, Garth D. Nelson, Thomas J. Flotte, Eric P. Grewal, Jun Chen, Robert R. McWilliams, Lisa A. Kottschade, Lu Yang, Evidio Domingo-Musibay, Roxana S. Dronca, Yiyi Yan, Svetomir N. Markovic, Anastasios Dimou, Heather N. Montane, Courtney L. Erskine, Mara A. Piltin, Daniel L. Price, Samir S. Khariwala, Jane Hui, Carrie A. Strand, Susan M. Harrington, Vera J. Suman, Haidong Dong, Matthew S. Block
Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Both targeted therapies and immunotherapies provide benefit in resected Stage III melanoma. We hypothesized that the combination of targeted and immunotherapy given prior to therapeutic lymph node dissection (TLND) would be tolerable and dri
Externí odkaz: https://doaj.org/article/6734662876464a8cb916380502e32069
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6
Akademický článek
Proton Craniospinal Irradiation with Immunotherapy in Two Patients with Leptomeningeal Disease from Melanoma
Autor: Ugur Sener, Mason Webb, William G. Breen, Bryan J. Neth, Nadia N. Laack, David Routman, Paul D. Brown, Anita Mahajan, Kelsey Frechette, Arkadiusz Z. Dudek, Svetomir N. Markovic, Matthew S. Block, Robert R. McWilliams, Anastasios Dimou, Lisa A. Kottschade, Heather N. Montane, Sani H. Kizilbash, Jian L. Campian
Publikováno v: Journal of Immunotherapy and Precision Oncology, Vol 7, Iss 1, Pp 1-6 (2024)
Introduction Proton craniospinal irradiation (pCSI) is a treatment option for leptomeningeal disease (LMD), which permits whole neuroaxis treatment while minimizing toxicity. Despite this, patients inevitably experience progression. Adding systemic t
Externí odkaz: https://doaj.org/article/e46cf582bd95407aa5330e020924b4ae
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8
SALVO: Single-Arm Trial of Ipilimumab and Nivolumab as Adjuvant Therapy for Resected Mucosal Melanoma
Autor: Lisa A. Kottschade, Gregory Russell Pond, Anthony J. Olszanski, Yousef Zakharia, Evidio Domingo-Musibay, Ralph J. Hauke, Brendan D. Curti, Sarah Schober, Mohammed M. Milhem, Matthew Stephen Block, Tina Hieken, Robert R. McWilliams
Publikováno v: Clinical Cancer Research. :OF1-OF6
Purpose: Mucosal melanoma is a rare, aggressive form of melanoma with extremely high recurrence rates despite definitive surgical resection with curative intent. Currently there is no consensus on adjuvant therapy. Data on checkpoint inhibitors for a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f17632ed77ac64bf22946772a46e3ef1
https://doi.org/10.1158/1078-0432.ccr-22-3207
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