Data-driven identification of predictive risk biomarkers for subgroups of osteoarthritis using interpretable machine learning

Autor: Rikke Linnemann Nielsen, Thomas Monfeuga, Robert R. Kitchen, Line Egerod, Luis G. Leal, August Thomas Hjortshøj Schreyer, Frederik Steensgaard Gade, Carol Sun, Marianne Helenius, Lotte Simonsen, Marianne Willert, Abd A. Tahrani, Zahra McVey, Ramneek Gupta

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Osteoarthritis (OA) is increasing in prevalence and has a severe impact on patients’ lives. However, our understanding of biomarkers driving OA risk remains limited. We developed a model predicting the five-year risk of OA diagnosis, integ

Externí odkaz: https://doaj.org/article/35ed3f0bace2485dadb823e4a9c370cd

Hepatocyte mARC1 promotes fatty liver disease

Autor: Lara C. Lewis, Lingyan Chen, L. Shahul Hameed, Robert R. Kitchen, Cyrielle Maroteau, Shilpa R. Nagarajan, Jenny Norlin, Charlotte E. Daly, Iwona Szczerbinska, Sara Toftegaard Hjuler, Rahul Patel, Eilidh J. Livingstone, Tom N. Durrant, Elisabeth Wondimu, Soumik BasuRay, Anandhakumar Chandran, Wan-Hung Lee, Sile Hu, Barak Gilboa, Megan E. Grandi, Enrique M. Toledo, Abdullah H.A. Erikat, Leanne Hodson, William G. Haynes, Natalie W. Pursell, Ken Coppieters, Jan Fleckner, Joanna M.M. Howson, Birgitte Andersen, Maxwell A. Ruby

Publikováno v: JHEP Reports, Vol 5, Iss 5, Pp 100693- (2023)

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has a prevalence of ∼25% worldwide, with significant public health consequences yet few effective treatments. Human genetics can help elucidate novel biology and identify targets for new

Externí odkaz: https://doaj.org/article/dfadb6aa5c1e408c8dd0a8e68452c677

Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research

Autor: Bogdan Mateescu, Jennifer C. Jones, Roger P. Alexander, Eric Alsop, Ji Yeong An, Mohammad Asghari, Alex Boomgarden, Laura Bouchareychas, Alfonso Cayota, Hsueh-Chia Chang, Al Charest, Daniel T. Chiu, Robert J. Coffey, Saumya Das, Peter De Hoff, Andrew deMello, Crislyn D’Souza-Schorey, David Elashoff, Kiarash R. Eliato, Jeffrey L. Franklin, David J. Galas, Mark B. Gerstein, Ionita H. Ghiran, David B. Go, Stephen Gould, Tristan R. Grogan, James N. Higginbotham, Florian Hladik, Tony Jun Huang, Xiaoye Huo, Elizabeth Hutchins, Dennis K. Jeppesen, Tijana Jovanovic-Talisman, Betty Y.S. Kim, Sung Kim, Kyoung-Mee Kim, Yong Kim, Robert R. Kitchen, Vaughan Knouse, Emily L. LaPlante, Carlito B. Lebrilla, L. James Lee, Kathleen M. Lennon, Guoping Li, Feng Li, Tieyi Li, Tao Liu, Zirui Liu, Adam L. Maddox, Kyle McCarthy, Bessie Meechoovet, Nalin Maniya, Yingchao Meng, Aleksandar Milosavljevic, Byoung-Hoon Min, Amber Morey, Martin Ng, John Nolan, Getulio P. De Oliveira Junior, Michael E. Paulaitis, Tuan Anh Phu, Robert L. Raffai, Eduardo Reátegui, Matthew E. Roth, David A. Routenberg, Joel Rozowsky, Joseph Rufo, Satyajyoti Senapati, Sigal Shachar, Himani Sharma, Anil K. Sood, Stavros Stavrakis, Alessandra Stürchler, Muneesh Tewari, Juan P. Tosar, Alexander K. Tucker-Schwartz, Andrey Turchinovich, Nedyalka Valkov, Kendall Van Keuren-Jensen, Kasey C. Vickers, Lucia Vojtech, Wyatt N. Vreeland, Ceming Wang, Kai Wang, ZeYu Wang, Joshua A. Welsh, Kenneth W. Witwer, David T.W. Wong, Jianping Xia, Ya-Hong Xie, Kaichun Yang, Mikołaj P. Zaborowski, Chenguang Zhang, Qin Zhang, Angela M. Zivkovic, Louise C. Laurent

Publikováno v: iScience, Vol 25, Iss 8, Pp 104653- (2022)

Summary: The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013–2018), Phase 2 of the progr

Externí odkaz: https://doaj.org/article/d72ed055b3ab4740b73e722d85b82959

Whole-genome sequencing of phenotypically distinct inflammatory breast cancers reveals similar genomic alterations to non-inflammatory breast cancers

Autor: Xiaotong Li, Sushant Kumar, Arif Harmanci, Shantao Li, Robert R. Kitchen, Yan Zhang, Vikram B. Wali, Sangeetha M. Reddy, Wendy A. Woodward, James M. Reuben, Joel Rozowsky, Christos Hatzis, Naoto T. Ueno, Savitri Krishnamurthy, Lajos Pusztai, Mark Gerstein

Publikováno v: Genome Medicine, Vol 13, Iss 1, Pp 1-14 (2021)

Abstract Background Inflammatory breast cancer (IBC) has a highly invasive and metastatic phenotype. However, little is known about its genetic drivers. To address this, we report the largest cohort of whole-genome sequencing (WGS) of IBC cases. Meth

Externí odkaz: https://doaj.org/article/1add699a6a154a93abe43aacbd318851

Correction to: Evaluation of serological lateral flow assays for severe acute respiratory syndrome coronavirus-2

Autor: Bianca A. Trombetta, Savannah E. Kandigian, Robert R. Kitchen, Korneel Grauwet, Pia Kivisäkk Webb, Glenn A. Miller, Charles G. Jennings, Sejal Jain, Samara Miller, Yikai Kuo, Thadryan Sweeney, Tal Gilboa, Maia Norman, Daimon P. Simmons, Christopher E. Ramirez, Melissa Bedard, Catherine Fink, Jina Ko, Esmarline J. De León Peralta, Gerald Watts, Emma Gomez-Rivas, Vannessa Davis, Rocky M. Barilla, Jianing Wang, Pierre Cunin, Samuel Bates, Chevaun Morrison-Smith, Benjamin Nicholson, Edmond Wong, Leena El-Mufti, Michael Kann, Anna Bolling, Brooke Fortin, Hayden Ventresca, Wen Zhou, Santiago Pardo, Megan Kwock, Aditi Hazra, Leo Cheng, Q. Rushdy Ahmad, James A. Toombs, Rebecca Larson, Haley Pleskow, Nell Meosky Luo, Christina Samaha, Unnati M. Pandya, Pushpamali De Silva, Sally Zhou, Zakary Ganhadeiro, Sara Yohannes, Rakiesha Gay, Jacqueline Slavik, Shibani S. Mukerji, Petr Jarolim, David R. Walt, Becky C. Carlyle, Lauren L. Ritterhouse, Sara Suliman

Publikováno v: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-2 (2021)

Externí odkaz: https://doaj.org/article/9bc96019ccbf40a28e5cc85682a0a561