Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Robert Pola"'
Publikováno v:
View, Vol 5, Iss 3, Pp n/a-n/a (2024)
Abstract Nano‐sized polymer systems are often used as carriers for drugs and contrast agents to increase circulation time and solubility and to reduce possible side effects. These nanomedicines usually accumulate in tumor tissue due to the enhanced
Externí odkaz:
https://doaj.org/article/d1cc2e758667477eaad93f69b7ed485b
Autor:
Robert Pola, Matěj Vícha, Jiří Trousil, Eliška Grosmanová, Michal Pechar, Anna Rumlerová, Martin Studenovský, Emilie Kučerová, Pavel Ulbrich, Barbora Vokatá, Tomáš Etrych
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 406 (2023)
Microbial resistance is one of the main problems of modern medicine. Recently, antimicrobial peptides have been recognized as a novel approach to overcome the microbial resistance issue, nevertheless, their low stability, toxicity, and potential immu
Externí odkaz:
https://doaj.org/article/6e2ad2d33b7a447d9071a7a83234c683
Autor:
Marina Rodrigues Tavares, Kaplan Kirakci, Nikolay Kotov, Michal Pechar, Kamil Lang, Robert Pola, Tomáš Etrych
Publikováno v:
Nanomaterials, Vol 12, Iss 19, p 3350 (2022)
Photo/radiosensitizers, such as octahedral molybdenum clusters (Mo6), have been intensively studied for photodynamic applications to treat various diseases. However, their delivery to the desired target can be hampered by its limited solubility, low
Externí odkaz:
https://doaj.org/article/4013b5f5646a432fb11b5e3b48b8962b
Autor:
Sijumon Kunjachan, Shady Kotb, Robert Pola, Michal Pechar, Rajiv Kumar, Bijay Singh, Felix Gremse, Reza Taleeli, Florian Trichard, Vincent Motto-Ros, Lucie Sancey, Alexandre Detappe, Sayeda Yasmin-Karim, Andrea Protti, Ilanchezhian Shanmugam, Thomas Ireland, Tomas Etrych, Srinivas Sridhar, Olivier Tillement, Mike Makrigiorgos, Ross I. Berbeco
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/2c82c277248e4a02b43739d34a115517
Autor:
Barbora Kalousková, Ondřej Skořepa, Denis Cmunt, Celeste Abreu, Kateřina Krejčová, Jan Bláha, Irena Sieglová, Vlastimil Král, Milan Fábry, Robert Pola, Michal Pechar, Ondřej Vaněk
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1597 (2021)
Targeted cancer immunotherapy is a promising tool for restoring immune surveillance and eradicating cancer cells. Hydrophilic polymers modified with coiled coil peptide tags can be used as universal carriers designed for cell-specific delivery of suc
Externí odkaz:
https://doaj.org/article/2c9043d3a1e7484f806ef4bdcff6e30e
Autor:
Eliška Böhmová, Robert Pola, Michal Pechar, Jozef Parnica, Daniela Machová, Olga Janoušková, Tomáš Etrych
Publikováno v:
Pharmaceutics, Vol 12, Iss 1, p 59 (2020)
Cell-penetrating peptides (CPPs) are commonly used substances enhancing the cellular uptake of various cargoes that do not easily cross the cellular membrane. CPPs can be either covalently bound directly to the cargo or they can be attached to a tran
Externí odkaz:
https://doaj.org/article/de87313135784f86a1659eae1884b1f0
Autor:
Robert Pola, Eliška Böhmová, Marcela Filipová, Michal Pechar, Jan Pankrác, David Větvička, Tomáš Olejár, Martina Kabešová, Pavla Poučková, Luděk Šefc, Michal Zábrodský, Olga Janoušková, Jan Bouček, Tomáš Etrych
Publikováno v:
Pharmaceutics, Vol 12, Iss 1, p 31 (2020)
This report describes the design, synthesis and evaluation of tumor-targeted polymer probes to visualize epidermal growth factor receptor (EGFR)-positive malignant tumors for successful resection via fluorescence guided endoscopic surgery. Fluorescen
Externí odkaz:
https://doaj.org/article/913f058206dd4cfaa7155126fd21ca6c
Autor:
Okan Tezcan, Asmaa Said Elshafei, Karina Benderski, Elena Rama, Maike Wagner, Diana Moeckel, Robert Pola, Michal Pechar, Tomas Etrych, Saskia von Stillfried, Fabian Kiessling, Ralf Weiskirchen, Steffen Meurer, Twan Lammers
Publikováno v:
J Control Release
Journal of Controlled Release
Journal of Controlled Release
Multidrug resistance (MDR) reduces the efficacy of chemotherapy. Besides inducing the expression of drug efflux pumps, chemotherapy treatment alters the composition of the tumor microenvironment (TME), thereby potentially limiting tumor-directed drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241f6ce4fad1ea8db0f15bf0ccaa1d50
https://europepmc.org/articles/PMC7614501/
https://europepmc.org/articles/PMC7614501/
Autor:
Anna Schulte, Andres de los Santos Pereira, Robert Pola, Ognen Pop‐Georgievski, Siyu Jiang, Iryna Romanenko, Manisha Singh, Zdeňka Sedláková, Holger Schönherr, Rafał Poręba
Publikováno v:
Macromolecular bioscience.
Cell sheet harvesting offers a great potential for the development of new therapies for regenerative medicine. For cells to adhere onto surfaces, proliferate, and to be released on demand, thermoresponsive polymeric coatings are generally considered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4af47f6a3bfa807ffa9b9a895e5e53f9
https://pubmed.ncbi.nlm.nih.gov/36598869
https://pubmed.ncbi.nlm.nih.gov/36598869
Acid-responsive HPMA copolymer-bradykinin conjugate enhances tumor-targeted delivery of nanomedicine
Autor:
Ondřej Lidický, Tomáš Etrych, Enoch Appiah, Robert Pola, Eliška Grossmanová, Mamoru Haratake, Hideaki Nakamura, Akihiko Kuniyasu
Publikováno v:
Journal of Controlled Release. 337:546-556
Obstructed blood flow and erratic blood supply in the tumor region attenuate the distribution and accumulation of nanomedicines in the tumor. Therefore, improvement of these conditions is crucial for efficient drug delivery. In this study, we designe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e68ce45c0cfc58defb70a27287bee5b
https://doi.org/10.1016/j.jconrel.2021.08.009
https://doi.org/10.1016/j.jconrel.2021.08.009