Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Robert Ploemacher"'
Publikováno v:
Scandinavian Journal of Haematology. 19:424-434
Phenylhydrazine treatment of normal mice elicited a rise in the numbers of CFU-S in blood, spleen and liver. High numbers of CFU-S were found in blood and liver 4 d after the first phenylhydrazine injection. CFU-S in the liver decreased slowly and we
Autor:
E. M. Noordegraaf, Robert Ploemacher
Publikováno v:
Scandinavian Journal of Haematology. 24:152-156
The possible relation between haemopoietic activity and glycosaminoglycan levels in the haemopoietic microenvironment was examined in ectopic erythropoiesis, induced by phenylhydrazine treatment, in the liver of adult mice. The hepatic glycosaminogly
Publikováno v:
Bone Marrow Transplantation. 33:153-159
Treosulfan is a water-soluble structural analog of busulfan, acting as a prodrug of alkylating epoxide species. It does not induce severe hepatotoxicity or veno-occlusive disease at or above the maximum tolerated dose, lacks significant nonhematologi
Publikováno v:
Bone Marrow Transplantation. 32:15-22
To investigate whether we could create a radiation-free conditioning regimen to induce permanent mixed and multilineage chimerism and donor-specific tolerance, we treated recipient mice with anti-T-cell antibodies, varying and fractionated doses of T
Autor:
Robert Ploemacher, W. J. C. Rombouts
Publikováno v:
Leukemia. 17:160-170
Recent studies describe beneficial effects of bone marrow-derived mesenchymal stem cell infusion in animal models as well as in patients. However, data on the homing abilities of primary and culture-expanded MSC are lacking. In order to systematicall
Publikováno v:
Leukemia, 16, 1782-1790. Nature Publishing Group
The first definitive long-term repopulating hematopoietic stem cells (HSCs) emerge from and undergo rapid expansion in the embryonic aorta-gonad-mesonephros (AGM) region. To investigate the presumptive unique characteristics of the embryonic hematopo
Publikováno v:
Leukemia, 15, 1046-1053. Nature Publishing Group
The heterogeneity of acute myeloid leukemia is reflected in many clinical, biological and genetic features that are used to predict the response to therapy. On the basis of chromosome aberrations patients can be stratified in groups reflecting either
Publikováno v:
Leukemia, 14, 1944-1953. Nature Publishing Group
In view of the limited potential for rapid hematological recovery after transplantation of umbilical cord blood cells (UCB) in adults, we have attempted to expand CD34+ selected hemopoietic stem cells (HSC) and progenitors in 2-week cultures of whole
Publikováno v:
Leukemia, 14, 675-683. Nature Publishing Group
Internal tandem duplications of the FIt3 gene (FIt3/ITDs) are present in about 18% of all AML cases and are therefore one of the most frequent somatic gene mutations in AML. Little is known about the role of FIt3/ITDs in leukemogenesis or their clini
Autor:
Robert Ploemacher
Publikováno v:
Baillière's Clinical Haematology. 10:429-444
The process of blood formation is sustained throughout an individual's life by a small population of haemopoietic stem cells (HSCs). The HSC compartment represents a hierarchy of HSC subsets with decreasing proliferative ability. This heterogeneity i