Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Robert Planque"'
Autor:
Zhaozheng Meng, Rebecca A Capel, Samuel J Bose, Erik Bosch, Sophia de Jong, Robert Planque, Antony Galione, Rebecca AB Burton, Alfonso Bueno-Orovio
Spontaneous calcium release by ryanodine receptors (RyRs) due to intracellular calcium overload results in delayed afterdepolarisations, closely associated with life-threatening arrhythmias. In this regard, inhibiting lysosomal calcium release by two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::39030d8c98485ccaec44f65d5d9c256f
https://doi.org/10.1101/2022.11.09.515777
https://doi.org/10.1101/2022.11.09.515777
Autor:
Robert Planque, Hulshof, J.
Publikováno v:
Planqué, R & Hulshof, J 2019, Metabolic pathways and optimisation . in M A Peletier, R A van Santen & E Steur (eds), Complexity Science : An Introduction . World Scientific Publishing Co. Pte Ltd, Singapore, pp. 375-392 . https://doi.org/10.1142/10973
Scopus-Elsevier
Scopus-Elsevier
In this chapter, we give a short introduction into metabolic pathway modelling using ordinary differential equations, and consider several different optimisation problems routinely solved by microbes such as bacteria and yeasts. These include maximis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acad5e8812b80c5d3ba58948a869de1d
https://hdl.handle.net/1871.1/a73bcb8c-19f9-4721-8e94-db498a861ade
https://hdl.handle.net/1871.1/a73bcb8c-19f9-4721-8e94-db498a861ade
Publikováno v:
Planque, R, Hulshof, J, Teusink, B, Hendriks, J C & Bruggeman, F J 2017, ' Maintaining maximal metabolic rates by gene expression control ', bioRxiv .
Vrije Universiteit Amsterdam
bioRxiv. Cold Spring Harbor Laboratory Press
Vrije Universiteit Amsterdam
bioRxiv. Cold Spring Harbor Laboratory Press
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::aaa6b4d062ba0ed80c50baa032c1d8df
https://hdl.handle.net/1871.1/2ea68008-62db-4c35-b9d8-42f8121ecd3c
https://hdl.handle.net/1871.1/2ea68008-62db-4c35-b9d8-42f8121ecd3c
Publikováno v:
Planque, R, Bhulai, S, Hulshof, J, Kager, W & Rot, T O 2012, Proceedings of the Seventy-ninth European Study Group Mathematics with Industry . VU Uitgeverij, Amsterdam .
Vrije Universiteit Amsterdam
Vrije Universiteit Amsterdam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7fc708733332edacb21cea9a96a1b8ac
https://research.vu.nl/en/publications/184e29bb-ae70-4442-9f03-e6ed37fed64e
https://research.vu.nl/en/publications/184e29bb-ae70-4442-9f03-e6ed37fed64e
Autor:
Tom J. Clement, Erik B. Baalhuis, Bas Teusink, Frank J. Bruggeman, Robert Planqué, Daan H. de Groot
Publikováno v:
Patterns, Vol 2, Iss 1, Pp 100177- (2021)
Summary: The metabolic capabilities of cells determine their biotechnological potential, fitness in ecosystems, pathogenic threat levels, and function in multicellular organisms. Their comprehensive experimental characterization is generally not feas
Externí odkaz:
https://doaj.org/article/542d7c9dba304aa99302afe355e88bd2
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 1, p e1007559 (2020)
In this paper we try to describe all possible molecular states (phenotypes) for a cell that fabricates itself at a constant rate, given its enzyme kinetics and the stoichiometry of all reactions. For this, we must understand the process of cellular g
Externí odkaz:
https://doaj.org/article/394a6e8eb7234b55802724e5386eee9d
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 3, p e1006858 (2019)
Growth rate is a near-universal selective pressure across microbial species. High growth rates require hundreds of metabolic enzymes, each with different nonlinear kinetics, to be precisely tuned within the bounds set by physicochemical constraints.
Externí odkaz:
https://doaj.org/article/5ad5cd11d6a74f15bbe1084596d8d5b0
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 9, p e1006412 (2018)
One of the marvels of biology is the phenotypic plasticity of microorganisms. It allows them to maintain high growth rates across conditions. Studies suggest that cells can express metabolic enzymes at tuned concentrations through adjustment of gene
Externí odkaz:
https://doaj.org/article/66255b5bc4de4b739fcdf705c66c8044
Autor:
Johan H. van Heerden, Meike T. Wortel, Frank J. Bruggeman, Joseph J. Heijnen, Yves J.M. Bollen, Robert Planqué, Josephus Hulshof, Tom G. O’Toole, S. Aljoscha Wahl, Bas Teusink
Publikováno v:
Microbial Cell, Vol 1, Iss 3, Pp 103-106 (2015)
In the model eukaryote Saccharomyces cerevisiae, it has long been known that a functional trehalose pathway is indispensable for transitions to high glucose conditions. Upon addition of glucose, cells with a defect in trehalose 6-phosphate synthase (
Externí odkaz:
https://doaj.org/article/dd2ccf032fec4f26af023e85a24c081a
Publikováno v:
Scopus-Elsevier
STARTPAGE=5;ENDPAGE=10;TITLE=10th International Conference on Simulation and Modelling in the Food and Bio-Industry 2018, FOODSIM 2018
STARTPAGE=5;ENDPAGE=10;TITLE=10th International Conference on Simulation and Modelling in the Food and Bio-Industry 2018, FOODSIM 2018
Microbial cells evolved a remarkable ability to adapt to environmental conditions, or to withstand otherwise detrimental mutations, which makes them often very resilient to man-made interventions. These properties arise from the integrative functioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0666cc7eebe5729a6e2101299d06c03b
http://www.scopus.com/inward/record.url?eid=2-s2.0-85050298148&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-85050298148&partnerID=MN8TOARS