Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Robert Pinard"'
Autor:
Raymond J Kelleher, Ute Geigenmüller, Hayk Hovhannisyan, Edwin Trautman, Robert Pinard, Barbara Rathmell, Randall Carpenter, David Margulies
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35003 (2012)
Identification of common molecular pathways affected by genetic variation in autism is important for understanding disease pathogenesis and devising effective therapies. Here, we test the hypothesis that rare genetic variation in the metabotropic glu
Externí odkaz:
https://doaj.org/article/58ae62ebf4ae49fdbec45e000d926f61
Autor:
Emily Neil, Dongju Park, Erica Lloyd, Michael Dibuono, Seiyu Hosono, Reto Muller, Hanna Lafayette, Hsinyi Smith, Robert Pinard
Publikováno v:
Cancer Research. 83:5643-5643
Recent technological breakthroughs in single cell sequencing have revealed that malignant cells and nonmalignant cells are both highly dynamic and in the case of tumor cells, that the intratumoral heterogeneity is quite remarkable. However, several q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04516b2da70f866f59edf201aa5f2d39
https://doi.org/10.1158/1538-7445.am2023-5643
https://doi.org/10.1158/1538-7445.am2023-5643
Autor:
Julia Femel, Emily Neil, Dongju Park, Fabio El Yassouri, Anijutta Appelshoffer, Erica Lloyd, Michael DiBuono, Henry Sauer, Hanna Lafayette, Hsinyi Smith, Jinling Wang, Dominic Mangiardi, Alex Makrigiorgos, Paurush Praveen, Silvia Rüberg, Werner Müller, Tanya Wantenaar, Robert Pinard, Andreas Bosio
Publikováno v:
Cancer Research. 83:5633-5633
With the advent of immunotherapies such as immune checkpoint inhibitors and CAR T cells, the interest in the tumor microenvironment and tumor-infiltrating lymphocytes (TILs) cells has increased in recent years as these play a critical role in predict
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db77ff9e0fc5e923bd4713d4d720a59f
https://doi.org/10.1158/1538-7445.am2023-5633
https://doi.org/10.1158/1538-7445.am2023-5633
Autor:
Robert Pinard1 robert.pinard@historx.com, Alex de Winter1 adewinter@pacificbiosciences.com, Gary J Sarkis1 gary.sarkis@ikonisys.com, Mark B Gerstein2 mark.gerstein@yale.edu, Tartaro, Karrie R1 ktartaro@454.com, Plant, Ramona N1 ramona.2.plant@gsk.com, Egholm, Michael1 megholm@454.com, Rothberg, Jonathan M1 jrothberg@454.com, Leamon, John H1 jleamon@454.com
Publikováno v:
BMC Genomics. 2006, Vol. 7, p216-21. 21p. 8 Charts, 6 Graphs.
Autor:
Mark D, Gustavson, Brian, Bourke-Martin, Dylan, Reilly, Melissa, Cregger, Christine, Williams, Jane, Mayotte, Maciej, Zerkowski, Greg, Tedeschi, Robert, Pinard, Jason, Christiansen
Publikováno v:
Archives of Pathology & Laboratory Medicine. 133:1413-1419
Context.—There is critical need for standardization of HER2 immunohistochemistry testing in the clinical laboratory setting. Recently, the American Society of Clinical Oncology and the College of American Pathologists have submitted guidelines reco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73a931dd3858d8cc84c4771769ecf800
https://doi.org/10.5858/133.9.1413
https://doi.org/10.5858/133.9.1413
Autor:
John M. Burke, Dominic Lambert, Robert Pinard, Philip A. Chan, Joyce E. Heckman, François Major, Ken J. Hampel
Publikováno v:
The EMBO Journal. 20:6434-6442
The catalytic determinants for the cleavage and ligation reactions mediated by the hairpin ribozyme are integral to the polyribonucleotide chain. We describe experiments that place G8, a critical guanosine, at the active site, and point to an essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98b020eed91173ee49dd271acc29b21
https://doi.org/10.1093/emboj/20.22.6434
https://doi.org/10.1093/emboj/20.22.6434
Publikováno v:
Journal of Molecular Biology. 287:239-251
The hairpin ribozyme-substrate complex contains two independently folding domains that interact with one another to form a catalytic complex. However, little is known about the key structural elements involved in these tertiary interactions. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b06e1b13f00fb5b373c63bd541553a9a
https://doi.org/10.1006/jmbi.1999.2626
https://doi.org/10.1006/jmbi.1999.2626
Publikováno v:
Synapse. 24:203-212
Previous works have shown the potential location of 5-HT1B binding sites on the retinal afferents to the superior colliculus in the rat. In order to confirm this hypothesis, the distribution of 5-HT1B binding sites, labelled by S-CM-G[125I]TNH2, was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cf51567f80ab18f6199119607c67d8
https://doi.org/10.1002/(sici)1098-2396(199611)24:3<203::aid-syn1>3.0.co
https://doi.org/10.1002/(sici)1098-2396(199611)24:3<203::aid-syn1>3.0.co
Publikováno v:
Journal of Molecular Biology. 259:207-215
Three single-point mutations and two multibase substitutions were introduced into the lower half of the 3' major domain of Escherichia coli 16 S ribosomal RNA. The three single mutations were located in helix 29 (U1341C) or in helix 43 (U1351C or A13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fa4f75b19a2beac6bf31e35bb1772a
https://doi.org/10.1006/jmbi.1996.0313
https://doi.org/10.1006/jmbi.1996.0313
Publikováno v:
Biochemistry and Cell Biology. 73:907-913
Mutations at position 13 or 914 of Escherichia coli 16S ribosomal RNA exert pleiotropic effects on protein synthesis. They interfere with the binding of streptomycin, a translational miscoding drug, to the ribosomes. They increase translational fidel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a3cb79944c368d1bddb332777d9f86
https://doi.org/10.1139/o95-098
https://doi.org/10.1139/o95-098