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Bacterial immunogenic α-galactosylceramide identified in the murine large intestine: dependency on diet and inflammation

Autor: Johanna von Gerichten, Dominic Lamprecht, Lukáš Opálka, Daphnée Soulard, Christian Marsching, Robert Pilz, Valentin Sencio, Silke Herzer, Bruno Galy, Viola Nordström, Carsten Hopf, Hermann-Josef Gröne, François Trottein, Roger Sandhoff

Publikováno v: Journal of Lipid Research, Vol 60, Iss 11, Pp 1892-1904 (2019)

The glycosphingolipid, α-galactosylceramide (αGalCer), when presented by CD1d on antigen-presenting cells, efficiently activates invariant natural killer T (iNKT) cells. Thereby, it modulates immune responses against tumors, microbial and viral inf

Externí odkaz: https://doaj.org/article/916935eb800d4a97908209492b1d14ed

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Sphingosine-1-Phosphate Recruits Macrophages and Microglia and Induces a Pro-Tumorigenic Phenotype That Favors Glioma Progression

Autor: Lavinia Arseni, Rakesh Sharma, Norman Mack, Deepthi Nagalla, Sibylle Ohl, Thomas Hielscher, Mahak Singhal, Robert Pilz, Hellmut Augustin, Roger Sandhoff, Christel Herold-Mende, Björn Tews, Peter Lichter, Martina Seiffert

Publikováno v: Cancers; Volume 15; Issue 2; Pages: 479

Glioblastoma is the most aggressive brain tumor in adults. Treatment failure is predominantly caused by its high invasiveness and its ability to induce a supportive microenvironment. As part of this, a major role for tumor-associated macrophages/micr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b53baf11b5e641b5dc5b8f4edd08c50

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Formation of keto-type ceramides in palmoplantar keratoderma based on biallelic KDSR mutations in patients

Autor: Judith Fischer, Adam Majcher, Roger Sandhoff, Elise Brischoux-Boucher, Alexander Enk, Silvia Mihalceanu, Elisabeth Grimm, Knut Schäkel, Anne-Claire Bursztejn, François Aubin, Lukáš Opálka, Lionel Van Maldergem, Robert Pilz

Publikováno v: Human Molecular Genetics. 31:1105-1114

Functional skin barrier requires sphingolipid homeostasis; 3-ketodihydrosphingosine reductase or KDSR is a key enzyme of sphingolipid anabolism catalyzing the reduction of 3-ketodihydrosphingosine to sphinganine. Biallelic mutations in the KDSR gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c454b962e71f364c25143a51b4b62fe8
https://doi.org/10.1093/hmg/ddab309

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Bacterial immunogenic α-galactosylceramide identified in the murine large intestine: dependency on diet and inflammation

Autor: Roger Sandhoff, Hermann-Josef Gröne, Robert Pilz, Bruno Galy, Carsten Hopf, Valentin Sencio, Dominic Lamprecht, Daphnée Soulard, Johanna von Gerichten, Silke Herzer, Lukáš Opálka, Christian Marsching, Viola Nordström, François Trottein

Publikováno v: Journal of Lipid Research, Vol 60, Iss 11, Pp 1892-1904 (2019)
Journal of Lipid Research
Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 2019, 60 (11), pp.1892-1904. ⟨10.1194/jlr.RA119000236⟩
Journal of Lipid Research, 2019, 60 (11), pp.1892-1904. ⟨10.1194/jlr.RA119000236⟩
J Lipid Res

International audience; The glycosphingolipid, α-galactosylceramide (αGalCer), when presented by CD1d on antigen-presenting cells, efficiently activates invariant natural killer T (iNKT) cells. Thereby, it modulates immune responses against tumors,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75689cc708adf4690d205d375f9fe9d
http://www.sciencedirect.com/science/article/pii/S0022227520322872

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Biallelic KDSR mutations mitigate the formation of novel keto‐type ceramides in human stratum corneum

Autor: Elisabeth Grimm, Judith Fischer, Adam Majcher, Lionel Van Maldergem, François Aubin, Lukáš Opálka, Robert Pilz, Anne-Claire Bursztejn, Elise Brischoux-Boucher, Roger Sandhoff

Publikováno v: The FASEB Journal. 35

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f5b402ea487cb199ec12c42ed86ad9a
https://doi.org/10.1096/fasebj.2021.35.s1.05329

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Renal globotriaosylceramide facilitates tubular albumin absorption and its inhibition protects against acute kidney injury

Autor: Ludger Johannes, Christian Marsching, Richard Jennemann, Damir Krunic, Christian Wunder, Roger Sandhoff, Ina Maria Schießl, Ivan Morace, Giuseppina Federico, Johanna von Gerichten, Viola Nordström, Hermann-Josef Gröne, Robert Pilz, Johannes Müthing

Publikováno v: Kidney international. 96(2)

To elucidate the physiologic function of renal globotriaosylceramide (Gb3/CD77), which up-to-date has been associated exclusively with Shiga toxin binding, we have analyzed renal function in Gb3-deficient mice. Gb3 synthase KO (Gb3S−/−) mice disp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7e04ed5737454e64b06d143c8c5f71
https://pubmed.ncbi.nlm.nih.gov/31331463

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On the thread problem for minimal surfaces

Autor: Robert Pilz

Publikováno v: Calculus of Variations and Partial Differential Equations. 5:117-136

For a given one-dimensional fixed boundary Γ in ℝ3 and a given constant c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce856f9db737b8daeea426f6ac9892b2
https://doi.org/10.1007/s005260050062

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