Influence of Cow’s Milk and Esomeprazole on the Absorption of Erlotinib: A Randomized, Crossover Pharmacokinetic Study in Lung Cancer Patients

Autor: Kersten D. Landa, Esther Oomen-de Hoop, Marthe S. Paats, G.D. Marijn Veerman, Ron H.J. Mathijssen, Robert Peric, Anne-Marie C. Dingemans, Teun van Gelder, Cor van der Leest, Suzanna D. Broerse, Stijn L.W. Koolen, Hugo B. Rutten, Christi M.J. Steendam, Huub Belderbos, Koen G. A. M. Hussaarts, Roelof W F van Leeuwen, Joachim G.J.V. Aerts

Publikováno v: Clinical Pharmacokinetics
Clinical Pharmacokinetics, 60(1), 69-77. Adis

Introduction: Erlotinib’s gastrointestinal solubility and absorption are decreased by proton pump inhibitors (PPIs). Since erlotinib is a lipophilic drug, we hypothesized that concomitant intake with the fatty beverage milk may be a feasible way to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e790cd1b0f87889be0200663d1844124
https://doi.org/10.1007/s40262-020-00910-1

Quantification of the tyrosine kinase inhibitor erlotinib in human scalp hair by liquid chromatography-tandem mass spectrometry: Pitfalls for clinical application

Autor: G.D. Marijn Veerman, Ron H.J. Mathijssen, Peter de Bruijn, Robert Peric, Joachim G.J.V. Aerts, Stijn L.W. Koolen, C. Louwrens Braal

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis, 172, 175-182. Elsevier

An LC–MS/MS method was developed and validated to quantify the tyrosine kinase inhibitor erlotinib in human scalp hair, as alternative matrix to monitor long-term erlotinib exposure. Hair samples from 10 lung cancer patients were measured and corre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1677b550df52579ebfb95e5a8a58fd4
https://pubmed.ncbi.nlm.nih.gov/31051406

Influence of cow’s milk on the absorption and exposure of erlotinib in NSCLC patients

Autor: Stijn L.W. Koolen, Hugo B. Rutten, Koen G A M Hussaarts, K. Landa, G.D.M. Veerman, S.D. Broerse, Ron H.J. Mathijssen, Joachim G.J.V. Aerts, T. van Gelder, Robert Peric, C. van der Leest, R. van Leeuwen, Marthe S. Paats, E. Oomen-de Hoop

Publikováno v: Annals of Oncology. 30:v632

Background Erlotinib is an oral EGFR tyrosine kinase inhibitor used in NSCLC. Drug absorption depends largely on its solubility in the stomach and gastrointestinal tract. Potentially, erlotinib -as lipophilic drug- is ought to dissolve better in a fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::04fede29373f2d6a1286198ae7187b02
https://doi.org/10.1093/annonc/mdz260.062

Diagnostic and Therapeutic Approaches in Respiratory Endoscopy

Autor: N.C. Van Walree, Robert Peric, Joachim G.J.V. Aerts, M. de Mol

Publikováno v: Endoscopy

The field of respiratory endoscopy has developed over the last decade. Endoscopy is now used for early detection, diagnostic procedures, endoscopic ultrasound and endobronchial inter‐ ventions. Bronchoscopy is a standard procedure for endoscopists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6192ad31a8973a97055973da9666976
http://www.intechopen.com/articles/show/title/diagnostic-and-therapeutic-approaches-in-respiratory-endoscopy

Tyrosine Kinase Inhibitors and Proton Pump Inhibitors: An Evaluation of Treatment Options

Autor: Alex L. T. Imholz, Teun van Gelder, Roelof W F van Leeuwen, Robert Peric, Frank G A Jansman, Anna K.L. Reyners, Nicole G. M. Hunfeld, Ron H.J. Mathijssen, Joachim G.J.V. Aerts, Jacobus Brouwers

Publikováno v: Clinical Pharmacokinetics, 56(7), 683-688. Adis
Clinical Pharmacokinetics
Clinical Pharmacokinetics, 56(7), 683-688. Springer International Publishing AG

Tyrosine kinase inhibitors (TKIs) have rapidly become an established factor in oncology, and have been shown to be effective in a wide variety of solid and hematologic malignancies. Use of the oral administration route of TKIs offers flexibility and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e22afa8c6b0f5f5b8dbf28bdc9d5902