Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Robert Paek"'
Publikováno v:
Journal of Controlled Release. 78:285-294
Lower extremity arterial occlusive disease results in tissue ischemia of the legs and is relatively common in the elderly. Clinically, it may be asymptomatic, cause muscle pain during exercise, or progress to a severe degree of ischemia that may resu
Autor:
Rajabrata Sarkar, Madison Ma, Lucy S. Brevetti, David S. Chang, Louis M. Messina, Robert Paek
Publikováno v:
Journal of Vascular Surgery. 34(3):489-496
Purpose: The initial purpose of this study was to determine the effects of intravascular adenoviral vector-mediated gene transfer of endothelial nitric oxide synthase (AdeNOS) on experimental hindlimb ischemia in the rat. Unexpectedly, administration
Autor:
Lucy S. Brevetti, Sandra Brady, Julien I. E. Hoffman, Robert Paek, Rajabrata Sarkar, Louis M. Messina
Publikováno v:
Journal of Surgical Research. 98:21-26
Many experimental models of hindlimb ischemia are characterized by spontaneous and rapid normalization of resting muscle blood flow (BF) rates which complicates the long-term evaluation of angiogenic therapies to reverse limb ischemia. We tested the
Publikováno v:
Anesthesia & Analgesia. :1294-1296
Severe hyponatremia is associated with a mortality rate of more than 50%, primarily from cerebral edema and central nervous system dysfunction. Water intoxication is an unusual but potentially lethal cause of perioperative hyponatremia. We report a p
Autor:
Jesse Baumgold, Robert Paek
Publikováno v:
Neurochemical Research. 17:375-379
Fluorescent oxonol dyes were used to measure changes in the membrane potential of two different cell lines each expressing Pi-hydrolysis coupled muscarinic receptors. Both SK-N-SH human neuroblastoma cells and m1-transfected A9 L cells express muscar
Publikováno v:
Life Sciences. 50:1755-1759
Stimulation of m1 and of m3 muscarinic receptors has previously been shown to increase intracellular cAMP levels in a variety of cells. Although the mechanism underlying this response is not fully understood, it has been hypothesized to be secondary
Publikováno v:
Journal of neurochemistry. 58(5)
Previous work has shown that stimulation of muscarinic receptors in various cell lines increases intracellular cyclic AMP (cAMP) levels. This unusual response has been hypothesized to be mediated by stimulation of calcium/calmodulin-sensitive adenyla
Publikováno v:
Scopus-Elsevier
The M1-selective muscarinic receptor antagonist pirenzepine (5,11-dihydro-11-[(4-methyl-1-piperazinyl)acetyl]-6H-pyrido[2,3-b] [1,4]benzodiazepin-6-one) was derivatized to explore points of attachment of functionalized side chains for the synthesis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffa3622e20233e3294e1c82fb0e8535
https://europepmc.org/articles/PMC3469255/
https://europepmc.org/articles/PMC3469255/
Autor:
Udai Kammula, Kenneth A. Jacobson, Jeff Zimmet, Robert Paek, Barton J. Bradbury, Jesse Baumgold
Publikováno v:
Scopus-Elsevier
A series of substituted azacycloalkyl analogues of the muscarinic agonist UH 5 (N-methyl-N-[4-(1-pyrrolidinyl)-2-butynyl]acetamide, 1a) were synthesized and evaluated pharmacologically. These compounds were developed as intermediates for further deri
Autor:
Louis M. Messina, Thomas K. Hunt, Sandra Brady, Philip C. Ursell, Lucy S. Brevetti, Mark D. Rollins, Robert Paek, Rajabrata Sarkar, David S. Chang
Publikováno v:
Journal of Vascular Surgery. (1):172-179
Purpose: The lack of suitable experimental models of chronic severe limb ischemia and deficiencies in the available methods that allow for direct intermittent measurement of regional limb perfusion are obstacles to the evaluation of recently develope