Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Robert P. Waranis"'
Autor:
Donna Nickels, Udo Ezike-Mkparu, John M. Tovar, Kenneth B. Sloan, Karen Ulmer, Robert P. Waranis, Surjit Singh, Thomas L. Murray, Thea Shanks, Scott Wasdo
Publikováno v:
Pharmaceutical Research. 20:639-645
Purpose. To determine whether the fluxes through hairless mouse skin for three homologous series of prodrugs of 5-fluorouracil (5-FU, 1) and 6-mercaptopurine (6-MP, 2) from saturated aqueous suspensions show dependencies on aqueous (SAQ) and isopropy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da95936fff72b01f02e7251a9083d482
https://doi.org/10.1023/a:1023207118209
https://doi.org/10.1023/a:1023207118209
Publikováno v:
International Journal of Pharmaceutics. 36:211-222
6-Mercaptopurine (6-MP) is active against psoriasis when given systemically but inactive when given topically. In order to optimize the rate of delivery of 6-MP through skin, the fluxes of 6-MP from vehicles and mixtures of vehicles exhibiting solubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99e1d4f040b16ea4c3ac01215373251a
https://doi.org/10.1016/0378-5173(87)90158-x
https://doi.org/10.1016/0378-5173(87)90158-x
Publikováno v:
Journal of Heterocyclic Chemistry. 25:1077-1081
Labile aminomethyl and hydroxymethyl derivatives of 6-mercaptopurine (I) (6-MP) and S6-acyloxymethyl-6-MP have been converted to stable acetyloxymethyl derivatives by their reaction with acetic anhydride. Analysis of the reaction products and compari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23d2eae07156a4d3fdfe4dade17fb204
https://doi.org/10.1002/jhet.5570250406
https://doi.org/10.1002/jhet.5570250406
Autor:
Kenneth B. Sloan, Robert P. Waranis
Publikováno v:
Journal of pharmaceutical sciences. 76(8)
A series of S6,9-bisacyloxymethyl-6-mercaptopurine (6,9-bis-6-MP) prodrug derivatives was synthesized and characterized. The solubilities of the derivatives in solvents (vehicles), which exhibited a wide range of polarities from water to oleic acid,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::190a3097cb70efaa0214079f8aa90f38
https://pubmed.ncbi.nlm.nih.gov/11002816
https://pubmed.ncbi.nlm.nih.gov/11002816
ChemInform Abstract: Hydroxymethylation and Aminomethylation of 6-Mercaptopurine and Its Derivatives
Publikováno v:
ChemInform. 20
Labile aminomethyl and hydroxymethyl derivatives of 6-mercaptopurine (I) (6-MP) and S6-acyloxymethyl-6-MP have been converted to stable acetyloxymethyl derivatives by their reaction with acetic anhydride. Analysis of the reaction products and compari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fbef953f30a9ecee48787ecf7fdb125
https://doi.org/10.1002/chin.198911203
https://doi.org/10.1002/chin.198911203