Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Robert P. Strosznajder"'
Autor:
Kinga Czubowicz, Mariusz Głowacki, Ewa Fersten, Ewa Kozłowska, Robert P. Strosznajder, Zbigniew Czernicki
Publikováno v:
Folia Neuropathologica, Vol 55, Iss 4, Pp 301-307 (2017)
Cytokines are widely known mediators of inflammation accompanying many neurodegenerative disorders including normal pressure hydrocephalus (NPH). NPH is caused by impaired cerebrospinal fluid (CSF) absorption and treated by surgical shunt insertion.
Externí odkaz:
https://doaj.org/article/adbb136865b84b12b68fc1596a728d25
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 12, p 6277 (2021)
Molecular studies have provided increasing evidence that Parkinson’s disease (PD) is a protein conformational disease, where the spread of alpha-synuclein (ASN) pathology along the neuraxis correlates with clinical disease outcome. Pathogenic forms
Externí odkaz:
https://doaj.org/article/152b98ecc98e46329bb7eb7b24033382
Autor:
Henryk Jęśko, Robert P. Strosznajder
Publikováno v:
Folia Neuropathologica, Vol 54, Iss 3, Pp 212-233 (2016)
Sirtuins (SIRT1 to -7) are unique histone deacetylases (HDACs) whose activity depends on NAD+, thus making them capable of sensing the cellular metabolic status. Sirtuins orchestrate the stress response and damage repair, and are able to modulate the
Externí odkaz:
https://doaj.org/article/fa51bb0666df4be8bb2358f419534ccc
Autor:
Magdalena Gąssowska-Dobrowolska, Henryk Jęśko, Robert P. Strosznajder, Iga Wieczorek, Przemysław L. Wencel, Walter J. Lukiw
Publikováno v:
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Alzheimer's disease (AD) induces time-dependent changes in sphingolipid metabolism, which may affect transcription regulation and neuronal phenotype. We, therefore, analyzed the influence of age, amyloid β precursor protein (AβPP), and the clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83e7b1103b26986a2f06b1f9095ec03
https://doi.org/10.3389/fnmol.2021.660104
https://doi.org/10.3389/fnmol.2021.660104
Autor:
Robert P. Strosznajder, Walter J. Lukiw, Przemysław L. Wencel, Magdalena Cieślik, Vivian Jaber, Sylwia Wójtowicz, Iga Wieczorek, Joanna B. Strosznajder, Grzegorz A. Czapski
Publikováno v:
Molecular Neurobiology
A growing body of evidence indicates that pathological forms of amyloid beta (Aβ) peptide contribute to neuronal degeneration and synaptic loss in Alzheimer’s disease (AD). In this study, we investigated the impact of exogenous Aβ1-42 oligomers (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234e99edf90427e1b2ce38b1a99c1f04
https://doi.org/10.1007/s12035-019-01819-y
https://doi.org/10.1007/s12035-019-01819-y
Publikováno v:
Molecular Neurobiology
Bioactive sphingolipids: sphingosine, sphingosine-1-phosphate (S1P), ceramide, and ceramide-1-phosphate (C1P) are increasingly implicated in cell survival, proliferation, differentiation, and in multiple aspects of stress response in the nervous syst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0239449900ef7310fe98d0fd2d47de5
http://europepmc.org/articles/PMC6476865
http://europepmc.org/articles/PMC6476865
Publikováno v:
Molecular Neurobiology
Sphingolipid signaling disturbances correlate with Alzheimer’s disease (AD) progression. We examined the influence of FTY720/fingolimod, a sphingosine analog and sphingosine-1-phosphate (S1P) receptor modulator, on the expression of sphingolipid me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8d69590cc5bef33c54dd787e7aa650
https://doi.org/10.1007/s12035-018-1040-x
https://doi.org/10.1007/s12035-018-1040-x
Autor:
Magdalena Cieślik, Przemysław L. Wencel, Joanna B. Strosznajder, Robert P. Strosznajder, Grzegorz A. Czapski, Sylwia Wójtowicz
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:281-288
Alzheimer's disease (AD) is characterized by the release of amyloid beta peptides (Aβ) in the form of monomers/oligomers which may lead to oxidative stress, mitochondria dysfunction, synaptic loss, neuroinflammation and, in consequence, to overactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d30b3c7399fa13b0b91b123052b512fb
https://doi.org/10.1016/j.bbamcr.2017.11.003
https://doi.org/10.1016/j.bbamcr.2017.11.003
Publikováno v:
Molecular Neurobiology
Poly(ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs) are involved in the regulation of cell metabolism, transcription, and DNA repair. Alterations of these enzymes may play a crucial role in Alzheimer's disease (AD). Our previous results indicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f9141dfee718f09dcf8ce2426c0904
http://europepmc.org/articles/PMC5948241
http://europepmc.org/articles/PMC5948241
Autor:
Nicola J. Curtin, Nathan A. Berger, Solomon H. Snyder, Raymond A. Swanson, Peter Radermacher, Csaba Szabó, Pal Pacher, Francisco Garcia Soriano, Robert S. B. Clark, Robert P. Strosznajder, Flavio Moroni, A. Hamid Boulares, Balazs Sumegi, Andrew L. Salzman, Valina L. Dawson, Salvatore Cuzzocrea, Alberto Chiarugi, Ted M. Dawson, Alexander Bürkle, Lucas Liaudet, György Haskó, Valérie C. Besson
Publikováno v:
British Journal of Pharmacology. 175:192-222
The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for potential therapeutic repurposing for non-oncological indications. Considering (a) the preclinical efficacy data with PARP inhibitors in non-oncological dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef6a56426ace2dc158875362d94a3819
https://doi.org/10.1111/bph.13748
https://doi.org/10.1111/bph.13748