Identifying RNA Biomarkers and Molecular Pathways Involved in Multiple Subtypes of Uveitis

Autor: Amr Zaki, Stephen R. Planck, Christopher D. Conrady, Suzanne S. Fei, Christina A. Harrington, Dongseok Choi, Albert T. Vitale, Robert P. Searles, Lynn M. Hassman, Lindsey Watson, Tammy M. Martin, Puthyda Keath, Sruthi Arepalli, James T. Rosenbaum, Claire Mitchell, Michael A. Paley

Publikováno v: Am J Ophthalmol

Uveitis is a heterogeneous collection of diseases. We tested the hypothesis that despite the diversity of uveitides, there could be common mechanisms shared by multiple subtypes, and that evidence of these common mechanisms may be detected as gene ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae07d1d077d71fd1b664133dc63ffc9
https://doi.org/10.1016/j.ajo.2021.01.007

RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery

Autor: Julja Burchard, Jayasri Narasimhan, Sonali Jindal, Lucia Carbone, Christina A. Harrington, Wesley Horton, Suzanne S. Fei, Nathan D. Pennock, Duanchen Sun, Robert P. Searles, Sheila Weinmann, Pepper Schedin, Zheng Xia

Publikováno v: BMC Medical Genomics, Vol 12, Iss 1, Pp 1-18 (2019)
BMC Medical Genomics

Background Formalin-fixed, paraffin-embedded (FFPE) tissues for RNA-seq have advantages over fresh frozen tissue including abundance and availability, connection to rich clinical data, and association with patient outcomes. However, FFPE-derived RNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9bcccb7960fefc1239e4af6f1ac42d7
https://doaj.org/article/23cdb8883d2b4c058fc474177b85152b

Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms

Autor: Chenwei Lin, Anna Reister Schultz, Courtney Follit, Robert H. Collins, Brian J. Druker, Christopher A. Eide, Daelynn R. Buelow, Haijiao Zhang, Yee Ling Lam, Hoang Ho, Hagop M. Kantarjian, Farhad Ravandi, Jorge E. Cortes, Amy S. Carlos, Guillermo Garcia-Manero, Richard S. Sweat, Jeffrey W. Tyner, Vinay K. Jain, Robert P. Searles, Samantha L. Savage, Sharyn D. Baker, Gautam Borthakur, Evan F. Lind, Rachel Henson, Daniel Bottomly, Libbey White, Erik Segerdell, Shannon K. McWeeney, Tamilla Nechiporuk, Beth Wilmot

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

FLT3 mutations are prevalent in AML patients and confer poor prognosis. Crenolanib, a potent type I pan-FLT3 inhibitor, is effective against both internal tandem duplications and resistance-conferring tyrosine kinase domain mutations. While crenolani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3f5a05aec1da728f1b1774d127f938
https://doaj.org/article/998f439604e74cef95464ecda676fa5a

Phenotypic and gene expression features associated with variation in chronic ethanol consumption in heterogeneous stock collaborative cross mice

Autor: Denesa R. Lockwood, Robert P. Searles, Robert Hitzemann, Tamara J. Phillips, Priscila Darakjian

Publikováno v: Genomics

Of the more than 100 studies that have examined relationships between excessive ethanol consumption and the brain transcriptome, few rodent studies have examined chronic consumption. Heterogeneous stock collaborative cross mice freely consumed ethano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d256841c87a28626f2b70f208c84ea3
https://pubmed.ncbi.nlm.nih.gov/32771621

Functional genomic landscape of acute myeloid leukaemia

Autor: Robert H. Collins, Deirdre Devine, Beth Wilmot, Justin Ramsdill, Erik Segerdell, Bruno C. Medeiros, Brian J. Druker, Dylan Nelson, Micaela E. Martinez, Ryan C. Johnson, Robert Schuff, Robert P. Searles, Scott Weir, James Dibb, Elie Traer, Pierrette Lo, Haijiao Zhang, Rachel Henson, Tara A. Macey, Isabel English, Cody Coblentz, Christopher A. Eide, Ceilidh Nichols, Aurora Blucher, Ryan M. Winters, David L. Wiest, Corinne Visser, Michael W. Deininger, Stephen E. Kurtz, Daniel A. Pollyea, Justin M. Watts, Amy S. Carlos, Denise C. Connolly, Andy Kaempf, Angela Rofelty, Samuel B. Luty, Rachel J. Cook, Jill Peters, Kristen Werth, Shannon K. McWeeney, Joseph Carroll, Samantha L. Savage, Ronan T. Swords, Uma Borate, Aashis Thapa, Abdusebur Jemal, Joelle Wolf, Patricia Kropf, Rebecca Smith, Tyler Sweeney, Russell T. Burke, Rachel R. Pallapati, Anna Reister Schultz, Kim Hien T. Dao, Daniel Bottomly, Cristina E. Tognon, Alexey V. Danilov, Jason M. Glover, Jason D. MacManiman, Michie Degnin, Amy Yates, Libbey White, David K. Edwards, Anupriya Agarwal, Christopher R. Cogle, Kevin Watanabe-Smith, Leylah Drusbosky, Nicola Long, Motomi Mori, Christopher S. Hourigan, Tara L. Lin, Chenwei Lin, Jacqueline Martinez, Bill H. Chang, Richie Carpenter, Stephen E. Spurgeon, Brian Junio, Marc M. Loriaux, Craig T. Jordan, Hibery Ho, Selina Qiuying Liu, Melissa L. Abel, Amanda d’Almeida, Jake Wagner, Jade Bryant, Jeffrey W. Tyner, Jessica Leonard, Kara Johnson

Publikováno v: Nature

The implementation of targeted therapies for acute myeloid leukaemia (AML) has been challenging because of the complex mutational patterns within and across patients as well as a dearth of pharmacologic agents for most mutational events. Here we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ec9f74bb9044f4d83aab7c87cd9b94
https://doi.org/10.1038/s41586-018-0623-z