Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Robert P. Schreiber"'
Autor:
Xiuli Zhang, S. Peter Goedegebuure, Michael Y. Chen, Rashmi Mishra, Felicia Zhang, Yik Yeung Yu, Kartik Singhal, Lijin Li, Feng Gao, Nancy B. Myers, Tammi Vickery, Jasreet Hundal, Michael D. McLellan, Mark A. Sturmoski, Samuel W. Kim, Ina Chen, Jesse T. Davidson, Narendra V. Sankpal, Stephanie Myles, Rama Suresh, Cynthia X. Ma, Ademuyiwa Foluso, Andrea Wang-Gillam, Sherri Davies, Ian S. Hagemann, Elaine R. Mardis, Obi Griffith, Malachi Griffith, Christopher A. Miller, Ted H. Hansen, Timothy P. Fleming, Robert D. Schreiber, William E. Gillanders
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Neoantigen vaccines can induce or enhance highly specific antitumor immune responses with minimal risk of autoimmunity. We have developed a neoantigen DNA vaccine platform capable of efficiently presenting both HLA class I and II
Externí odkaz:
https://doaj.org/article/361f87535f3347da8e2cfda87d75ab59
Autor:
Thomas Thisted, F. Donelson Smith, Arnab Mukherjee, Yuliya Kleschenko, Feng Feng, Zhi-Gang Jiang, Timothy Eitas, Kanam Malhotra, Zuzana Biesova, Adejumoke Onumajuru, Faith Finley, Anokhi Cifuentes, Guolin Zhang, Gaëlle H. Martin, Yoshiko Takeuchi, Kader Thiam, Robert D. Schreiber, Edward H. van der Horst
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract VISTA, an inhibitory myeloid-T-cell checkpoint, holds promise as a target for cancer immunotherapy. However, its effective targeting has been impeded by issues such as rapid clearance and cytokine release syndrome observed with previous VIST
Externí odkaz:
https://doaj.org/article/5baa81963d6e484cb872b3eac39edd59
Autor:
Roxane Tussiwand, Michael S. Behnke, Nicole M. Kretzer, Gary E. Grajales-Reyes, Theresa L. Murphy, Robert D. Schreiber, Kenneth M. Murphy, L. David Sibley
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT Immunity to Toxoplasma gondii at early stages of infection in C57BL/6 mice depends on gamma interferon (IFN-γ) production by NK cells, while at later stages it is primarily mediated by CD8 T cells. We decided to explore the requirement for
Externí odkaz:
https://doaj.org/article/dd378a1387414af696a0707ee5fde62a
Autor:
Tanner M. Johanns, Christopher A. Miller, Connor J. Liu, Richard J. Perrin, Diane Bender, Dale K. Kobayashi, Jian L. Campian, Michael R. Chicoine, Ralph G. Dacey, Jiayi Huang, Edward F. Fritsch, William E. Gillanders, Maxim N. Artyomov, Elaine R. Mardis, Robert D. Schreiber, Gavin P. Dunn
Publikováno v:
OncoImmunology, Vol 8, Iss 4 (2019)
Neoantigens represent promising targets for personalized cancer vaccine strategies. However, the feasibility of this approach in lower mutational burden tumors like glioblastoma (GBM) remains unknown. We have previously reported the use of an immunog
Externí odkaz:
https://doaj.org/article/8dde9e453942466c919f33fd089ee9d6
Autor:
Obi L. Griffith, Szeman Ruby Chan, Malachi Griffith, Kilannin Krysiak, Zachary L. Skidmore, Jasreet Hundal, Julie A. Allen, Cora D. Arthur, Daniele Runci, Mattia Bugatti, Alexander P. Miceli, Heather Schmidt, Lee Trani, Krishna-Latha Kanchi, Christopher A. Miller, David E. Larson, Robert S. Fulton, William Vermi, Richard K. Wilson, Robert D. Schreiber, Elaine R. Mardis
Publikováno v:
Cell Reports, Vol 17, Iss 1, Pp 249-260 (2016)
Estrogen receptor alpha-positive (ERα+) luminal tumors are the most frequent subtype of breast cancer. Stat1−/− mice develop mammary tumors that closely recapitulate the biological characteristics of this cancer subtype. To identify transforming
Externí odkaz:
https://doaj.org/article/6737bbc4d4f249dfa5517ca827b51afa
Autor:
Bijal A Parikh, Sytse J Piersma, Melissa A Pak-Wittel, Liping Yang, Robert D Schreiber, Wayne M Yokoyama
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005323 (2015)
Natural killer (NK) cells play a critical role in controlling murine cytomegalovirus (MCMV) and can mediate both cytokine production and direct cytotoxicity. The NK cell activation receptor, Ly49H, is responsible for genetic resistance to MCMV in C57
Externí odkaz:
https://doaj.org/article/d192f41449724b0088404987cfd6b986
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128636 (2015)
Although type I interferons (IFNs) were first described almost 60 years ago, the ability to monitor and modulate the functional activities of the individual IFN subtypes that comprise this family has been hindered by a lack of reagents. The major typ
Externí odkaz:
https://doaj.org/article/ffc145d0248048a0b0f3501c2560ea31
Autor:
Jane Q Chen, Hidetoshi Mori, Robert D Cardiff, Josephine F Trott, Russell C Hovey, Neil E Hubbard, Jesse A Engelberg, Clifford G Tepper, Brandon J Willis, Imran H Khan, Resmi K Ravindran, Szeman R Chan, Robert D Schreiber, Alexander D Borowsky
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129895 (2015)
Female 129:Stat1-null mice (129S6/SvEvTac-Stat1(tm1Rds) homozygous) uniquely develop estrogen-receptor (ER)-positive mammary tumors. Herein we report that the mammary glands (MG) of these mice have altered growth and development with abnormal termina
Externí odkaz:
https://doaj.org/article/29929a32a62840c7829521206f08d497
Autor:
Grzegorz B Gmyrek, Holly M Akilesh, Daniel B Graham, Anja Fuchs, Lihua Yang, Mark J Miller, Gabriel J Sandoval, Kathleen C F Sheehan, Robert D Schreiber, Michael S Diamond, Wojciech Swat
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76145 (2013)
Dap12 and FcRγ, the two transmembrane ITAM-containing signaling adaptors expressed in dendritic cells (DC), are implicated in the regulation of DC function. Several activating and adhesion receptors including integrins require these chains for their
Externí odkaz:
https://doaj.org/article/bb4f9cdcd8674162b5295e3728b7038e
Autor:
Amelia K Pinto, Stephane Daffis, James D Brien, Maria D Gainey, Wayne M Yokoyama, Kathleen C F Sheehan, Kenneth M Murphy, Robert D Schreiber, Michael S Diamond
Publikováno v:
PLoS Pathogens, Vol 7, Iss 12, p e1002407 (2011)
A genetic absence of the common IFN-α/β signaling receptor (IFNAR) in mice is associated with enhanced viral replication and altered adaptive immune responses. However, analysis of IFNAR(-/-) mice is limited for studying the functions of type I IFN
Externí odkaz:
https://doaj.org/article/15251df72baf4044a37494cd5b83a3c2