Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Robert P. P. Fuchs"'
Autor:
Joseph J. Loparo, Slobodan Jergic, Elizabeth S. Thrall, Seungwoo Chang, Karel Naiman, Nicholas E. Dixon, James E. Kath, Robert P. P. Fuchs
Publikováno v:
Proc Natl Acad Sci U S A
DNA lesions stall the replisome and proper resolution of these obstructions is critical for genome stability. Replisomes can directly replicate past a lesion by error-prone translesion synthesis. Alternatively, replisomes can reprime DNA synthesis do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5584d9851ab733dd7d4154c96b1151a
Autor:
Robert P. P. Fuchs
Publikováno v:
DNA Repair. 44:51-58
Lesion tolerance pathways allow cells to proceed with replication despite the presence of replication-blocking lesions in their genome. Following transient fork stalling, replication resumes downstream leaving daughter strand gaps opposite replicatio
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2016, 44 (16), pp.7691--7699
Nucleic Acids Research, 2016, 44 (16), pp.7691--7699
Nucleic Acids Research, Oxford University Press, 2016, 44 (16), pp.7691--7699
Nucleic Acids Research, 2016, 44 (16), pp.7691--7699
International audience; DNA damage tolerance pathways allow cells to duplicate their genomes despite the presence of replication blocking lesions. Cells possess two major tolerance strategies, namely translesion synthesis (TLS) and homology directed
Autor:
Hisaji Maki, Tsutomu Katayama, Mio Ikeda, Gaëlle Philippin, Asako Furukohri, Edward L. Loechler, Masahiro Akiyama, Robert P. P. Fuchs
Publikováno v:
Nucleic Acids Research
Escherichia coli DNA polymerase IV (Pol IV, also known as DinB) is a Y-family DNA polymerase capable of catalyzing translesion DNA synthesis (TLS) on certain DNA lesions, and accumulating data suggest that Pol IV may play an important role in copying
Crosstalk between replicative and translesional DNA polymerases: PDIP38 interacts directly with Polη
Autor:
Agnès M. Cordonnier, Agnès Tissier, Stéphane Coulon, Esther Klaile, Patricia Kannouche, Robert P. P. Fuchs, Régine Janel-Bintz
Publikováno v:
DNA Repair
DNA Repair, Elsevier, 2010, 9 (8), pp.922-928. ⟨10.1016/j.dnarep.2010.04.010⟩
DNA Repair, Elsevier, 2010, 9 (8), pp.922-928. ⟨10.1016/j.dnarep.2010.04.010⟩
Replicative DNA polymerases duplicate genomes in a very efficient and accurate mode. However their progression can be blocked by DNA lesions since they are unable to accommodate bulky damaged bases in their active site. In response to replication blo
Autor:
Pierre-Henri L. Gaillard, Charly Chahwan, Ewan R. Taylor, Samira Fekairi, Stéphane Coulon, Paul Russell, Sarah Scaglione, Cristian I. Ruse, Clare H. McGowan, Agnès Tissier, John R. Yates, Meng-Qiu Dong, Robert P. P. Fuchs
Publikováno v:
Cell
Cell, Elsevier, 2009, 138 (1), pp.78-89. ⟨10.1016/j.cell.2009.06.029⟩
Cell, Elsevier, 2009, 138 (1), pp.78-89. ⟨10.1016/j.cell.2009.06.029⟩
SummaryStructure-specific endonucleases resolve DNA secondary structures generated during DNA repair and recombination. The yeast 5′ flap endonuclease Slx1-Slx4 has received particular attention with the finding that Slx4 has Slx1-independent key f
Publikováno v:
Molecular Microbiology
Molecular Microbiology, Wiley, 2009, 71 (2), pp.305-314. ⟨10.1111/j.1365-2958.2008.06527.x⟩
Molecular Microbiology, Wiley, 2009, 71 (2), pp.305-314. ⟨10.1111/j.1365-2958.2008.06527.x⟩
Summary In Escherichia coli, RecF-dependent post-replication repair (PRR) permits cells to tolerate the potentially lethal effects of blocking lesions at the replication fork. We have developed an in vivo experimental system to study the PRR mechanis
Publikováno v:
DNA Repair
DNA Repair, Elsevier, 2007, 6 (12), pp.1726-31. ⟨10.1016/j.dnarep.2007.06.003⟩
DNA Repair, Elsevier, 2007, 6 (12), pp.1726-31. ⟨10.1016/j.dnarep.2007.06.003⟩
The Rad6/Rad18-dependent monoubiquitination of PCNA plays a crucial role in regulating replication past DNA damage in eukaryotic cells. We show here that in human cell-free extracts, efficient PCNA monoubiquitination requires both the synthesis of re
Autor:
Shingo Fujii, Robert P. P. Fuchs
Publikováno v:
Journal of Molecular Biology. 372:883-893
Living cells possess a panel of specialized DNA polymerases that deal with the large diversity of DNA lesions that occur in their genomes. How specialized DNA polymerases gain access to the replication intermediate in the vicinity of the lesion is un
Autor:
Robert P. P. Fuchs, Shingo Fujii
Publikováno v:
DNA Repair. 6:1032-1041
Duplication of DNA containing damaged bases is a challenge to DNA polymerases that normally replicate with high speed, high accuracy and high processivity undamaged templates only. When a replicative DNA polymerase encounters a chemically altered bas