Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Robert P. Newman"'
Autor:
Sharmistha Chakraborty, Daoyan Wei, Megan Tran, Frederick F Lang, Robert A Newman, Peiying Yang
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 54, Iss , Pp 101008- (2024)
Successful treatment of glioblastoma multiforme (GBM), an aggressive form of primary brain neoplasm, mandates the need to develop new therapeutic strategies. In this study, we investigated the potential of PBI-05204 in targeting GBM stem cells (GSCs)
Externí odkaz:
https://doaj.org/article/97980fdf54b14666a16e35b8b917352e
Publikováno v:
Frontiers in Animal Science, Vol 5 (2024)
BackgroundInfection by porcine respiratory and reproductive syncytial virus (PRRSV), swine influenza virus (SIV) and porcine epidemic diarrhea (PEDV) adversely affect worldwide pig production. Because effective control remains elusive the present res
Externí odkaz:
https://doaj.org/article/77e3aa2401094ac2955dbc2bae38e72b
Autor:
Anthony E. Postiglione, Laquaundra L. Adams, Ese S. Ekhator, Anuoluwapo E. Odelade, Supriya Patwardhan, Meenal Chaudhari, Avery S. Pardue, Anjali Kumari, William A. LeFever, Olivia P. Tornow, Tamer S. Kaoud, Johnathan Neiswinger, Jun Seop Jeong, Derek Parsonage, Kimberly J. Nelson, Dukka B. Kc, Cristina M. Furdui, Heng Zhu, Andrew J. Wommack, Kevin N. Dalby, Ming Dong, Leslie B. Poole, Jeremiah D. Keyes, Robert H. Newman
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107817- (2023)
Summary: Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are dysregulated in many pervasive diseases. Recently, we discovered that ERK1/2 is oxidized by signal-generated hydrogen peroxide in various cell types. Since the putative sites of oxi
Externí odkaz:
https://doaj.org/article/f86f308d6824464da8ac7565dac3a50d
Publikováno v:
Frontiers in Physics, Vol 11 (2023)
In recent years, FLASH irradiation has attracted significant interest in radiation research. Studies have shown that irradiation at ultra-high dose rates (FLASH) reduces the severity of toxicities in normal tissues compared to irradiation at conventi
Externí odkaz:
https://doaj.org/article/1e991257b03945a58fda1083af1e3942
Autor:
Honglin Chen, Steffen Durinck, Hetal Patel, Oded Foreman, Kathryn Mesh, Jeffrey Eastham, Roger Caothien, Robert J. Newman, Merone Roose-Girma, Spyros Darmanis, Soren Warming, Annalisa Lattanzi, Yuxin Liang, Benjamin Haley
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 431-449 (2022)
With the aim of expediting drug target discovery and validation for respiratory diseases, we developed an optimized method for in situ somatic gene disruption in murine lung epithelial cells via AAV6-mediated CRISPR-Cas9 delivery. Efficient gene edit
Externí odkaz:
https://doaj.org/article/113e78dbbb674feba29efc5e54161173
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Protein succinylation is an important post-translational modification (PTM) responsible for many vital metabolic activities in cells, including cellular respiration, regulation, and repair. Here, we present a novel approach that combines fea
Externí odkaz:
https://doaj.org/article/05ba5159bed749beae6d1133d9a0744b
Autor:
Sara Vaccaro, Alessandra Rossetti, Antonella Porrazzo, Simona Camero, Matteo Cassandri, Silvia Pomella, Miriam Tomaciello, Giampiero Macioce, Francesca Pedini, Giovanni Barillari, Cinzia Marchese, Rossella Rota, Giovanni Cenci, Mario Tombolini, Robert A. Newman, Peiying Yang, Silvia Codenotti, Alessandro Fanzani, Francesca Megiorni, Claudio Festuccia, Giuseppe Minniti, Giovanni Luca Gravina, Francesca Vulcano, Luisa Milazzo, Francesco Marampon
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Treatment of rhabdomyosarcoma (RMS), the most common a soft tissue sarcoma in childhood, provides intensive multimodal therapy, with radiotherapy (RT) playing a critical role for local tumor control. However, since RMS efficiently activates mechanism
Externí odkaz:
https://doaj.org/article/35544f0854274470951c3529077bc1d1
Publikováno v:
ACS Omega, Vol 6, Iss 43, Pp 29166-29170 (2021)
Externí odkaz:
https://doaj.org/article/be721524c99a452590129357eac401bc
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010835 (2022)
The transmission cycle of West Nile virus (WNV) involves multiple species of birds. The relative importance of various bird species to the overall transmission is often inferred from the level and duration of viremia that they experience upon infecti
Externí odkaz:
https://doaj.org/article/1a237cf7d9de47b1aeb29a5c12769a48
Autor:
Jeannette Delva-Wiley, Ese S. Ekhator, Laquaundra L. Adams, Supriya Patwardhan, Ming Dong, Robert H. Newman
Publikováno v:
Life, Vol 13, Iss 9, p 1811 (2023)
The cyclic AMP-dependent protein kinase (PKA) plays an essential role in the regulation of many important cellular processes and is dysregulated in several pervasive diseases, including diabetes, cardiovascular disease, and various neurodegenerative
Externí odkaz:
https://doaj.org/article/dc1df490949b41d4a8ac8201d02cf07b