Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Robert P. Mecham"'
Autor:
Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
SVEP1 is linked to numerous human diseases, though its disease-promoting mechanism has remained unclear. Here, the authors identify SVEP1 as a ligand for the orphan receptor PEAR1 and provide insight into the role of this interaction in cardiovascula
Externí odkaz:
https://doaj.org/article/00a5662500fa4216a282bb3c8ddfa931
Autor:
Claire A. Ruddiman, Richard Peckham, Melissa A. Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Bruce A. Corliss, P. Jordan Hall, Chien-Jung Lin, Shayn M. Peirce, Swapnil K. Sonkusare, Robert P. Mecham, Jessica E. Wagenseil, Brant E. Isakson
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environments remain el
Externí odkaz:
https://doaj.org/article/7e3053ea3fba4f4ebcd0e85d89274a84
Autor:
Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/7c4ce03f276947c5a06906eedf5397a8
Autor:
Amanda L. Mohabeer, Jeffrey T. Kroetsch, Meghan McFadden, Negin Khosraviani, Thomas J. Broekelmann, Guangpei Hou, Hangjun Zhang, Yu-Qing Zhou, Minyao Wang, Anthony O. Gramolini, Robert P. Mecham, Scott P. Heximer, Steffen-Sebastian Bolz, Michelle P. Bendeck
Publikováno v:
Matrix Biology Plus, Vol 12, Iss , Pp 100085- (2021)
Arterial stiffening is a significant predictor of cardiovascular disease development and mortality. In elastic arteries, stiffening refers to the loss and fragmentation of elastic fibers, with a progressive increase in collagen fibers. Type VIII coll
Externí odkaz:
https://doaj.org/article/1c0e6c4c6c564815be877bd0f3ad21d7
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
There is ample evidence supporting a role for angiotensin II type 2 receptor (AT2R) in counterbalancing the effects of angiotensin II (ang II) through the angiotensin II type 1 receptor by promoting vasodilation and having anti-inflammatory effects.
Externí odkaz:
https://doaj.org/article/283e70f0205542cf9439b02d48b8b6a9
Autor:
Haixia Zhang, Alex Hanson, Tobias Scherf de Almeida, Christopher Emfinger, Conor McClenaghan, Theresa Harter, Zihan Yan, Paige E. Cooper, G. Schuyler Brown, Eric C. Arakel, Robert P. Mecham, Atilla Kovacs, Carmen M. Halabi, Blanche Schwappach, Maria S. Remedi, Colin G. Nichols
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Cantu syndrome (CS) is caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunits, the most common mutations being SUR2[R1154Q] and SUR2[R1154W], carried by a
Externí odkaz:
https://doaj.org/article/49205ba65db14c0c92f39428e2cf79af
Autor:
Robert B. Hinton, Amy L. Juraszek, Amy M. Opoka, Benjamin J. Landis, J. Michael Smith, Robert P. Mecham, Kevin E. Bove
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 8, Iss 7, p 75 (2021)
Elastic fiber fragmentation (EFF) is a hallmark of aortic valve disease (AVD), and neovascularization has been identified as a late finding related to inflammation. We sought to characterize the relationship between early EFF and aberrant angiogenesi
Externí odkaz:
https://doaj.org/article/195740bf63654f3191c2ec4432d9a37a
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 5, Pp 487-499 (2015)
Mutations in the secreted glycoprotein ADAMTSL2 cause recessive geleophysic dysplasia (GD) in humans and Musladin–Lueke syndrome (MLS) in dogs. GD is a severe, often lethal, condition presenting with short stature, brachydactyly, stiff skin, joint
Externí odkaz:
https://doaj.org/article/e8534e7b6a6648f88a2245a4e021bde7
Publikováno v:
Tissue Engineering Part A. 29:187-199
Autor:
Bridget M. Brengle, Michelle Lin, Robyn A. Roth, Kara D. Jones, Jessica E. Wagenseil, Robert P. Mecham, Carmen M. Halabi
Publikováno v:
Matrix Biology. 117:1-14