Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Robert P. Hammer"'
Autor:
Xunde Xian, Yinyuan Ding, Marco Dieckmann, Li Zhou, Florian Plattner, Mingxia Liu, John S Parks, Robert E Hammer, Philippe Boucher, Shirling Tsai, Joachim Herz
Publikováno v:
eLife, Vol 13 (2024)
Externí odkaz:
https://doaj.org/article/e0bff3f517564c15ad5bbbe1b5a7648e
Publikováno v:
Cell Transplantation, Vol 17 (2008)
Previous studies have shown that 17,19,21-tri-N-methyl-Aβ16-22 peptide (Aβ16-22m), and a peptide analogue containing α,α-disubsituted amino acids (ααAA) in the hydrophobic core domain of Aβ, termed AMY-1, effectively inhibited full-length Aβ
Externí odkaz:
https://doaj.org/article/271076578dfb4e8ea5a9701eb2530e53
Autor:
Heather Scott, Katie Hill, Liuhong Chen, Kevin McDonnell, Philip Brandish, Nicholas Keen, Rachel Dodds, Laura L Goodfield, Robert P Hammer, Winston Lu, Tamera Ashworth, Hannah S Gardner, Luca Mascheroni, Tazmin Martin, Matthieu Masureel, Sandra Uhlenbroich, Marta Amaral, Julia Kristenson, Gemma E Mudd
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/106eccc88ac34f02b396bec325cdea45
Autor:
Joseph A. Garcia, Rui Chen, Min Xu, Sarah A. Comerford, Robert E. Hammer, Shelby D. Melton, Linda A. Feagins
Publikováno v:
PLoS ONE, Vol 18, Iss 3 (2023)
The microenvironment of solid tumors is characterized by oxygen and glucose deprivation. Acss2/HIF-2 signaling coordinates essential genetic regulators including acetate-dependent acetyl CoA synthetase 2 (Acss2), Creb binding protein (Cbp), Sirtuin 1
Externí odkaz:
https://doaj.org/article/c0b1686f6e834cf1a5842d53a8811899
Publikováno v:
PLoS Genetics, Vol 19, Iss 1, p e1010595 (2023)
Defective ribosome biogenesis (RiBi) underlies a group of clinically diverse human diseases collectively known as the ribosomopathies, core manifestations of which include cytopenias and developmental abnormalities that are believed to stem primarily
Externí odkaz:
https://doaj.org/article/1b21ea99c6e74ce281bd9d329146aa8d
Autor:
Theresa Pohlkamp, Xunde Xian, Connie H Wong, Murat S Durakoglugil, Gordon Chandler Werthmann, Takaomi C Saido, Bret M Evers, Charles L White III, Jade Connor, Robert E Hammer, Joachim Herz
Publikováno v:
eLife, Vol 10 (2021)
Apolipoprotein E4 (ApoE4) is the most important and prevalent risk factor for late-onset Alzheimer’s disease (AD). The isoelectric point of ApoE4 matches the pH of the early endosome (EE), causing its delayed dissociation from ApoE receptors and he
Externí odkaz:
https://doaj.org/article/3091328afffb402889ce2628db3b91a1
Autor:
Albert G. Linden, Shili Li, Hwa Y. Choi, Fei Fang, Masashi Fukasawa, Kosaku Uyeda, Robert E. Hammer, Jay D. Horton, Luke J. Engelking, Guosheng Liang
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 3, Pp 475-487 (2018)
Lipogenesis in liver is highest in the postprandial state; insulin activates SREBP-1c, which transcriptionally activates genes involved in FA synthesis, whereas glucose activates carbohydrate-responsive element-binding protein (ChREBP), which activat
Externí odkaz:
https://doaj.org/article/d01ebb180e1f41a7b9bb032aaf9d21a3
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225105 (2019)
The response to environmental stresses by eukaryotic organisms includes activation of protective biological mechanisms, orchestrated in part by transcriptional regulators. The tri-member Hypoxia Inducible Factor (HIF) family of DNA-binding transcript
Externí odkaz:
https://doaj.org/article/bcb03d18100b4e9988d8eaa09ebab5f7
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 12, Pp 2597-2605 (2014)
Elongation of very long chain fatty acid-like family member 6 (ELOVL6) is a fatty acyl elongase that performs the initial and rate-limiting condensing reaction required for microsomal elongation of long-chain fatty acids. Our previous in vitro studie
Externí odkaz:
https://doaj.org/article/af177f671c3a4ab38c451285e2b88098
Autor:
Xunde Xian, Yinyuan Ding, Marco Dieckmann, Li Zhou, Florian Plattner, Mingxia Liu, John S Parks, Robert E Hammer, Philippe Boucher, Shirling Tsai, Joachim Herz
Publikováno v:
eLife, Vol 6 (2017)
Low-density lipoprotein receptor-related protein 1 (LRP1) is a multifunctional cell surface receptor with diverse physiological roles, ranging from cellular uptake of lipoproteins and other cargo by endocytosis to sensor of the extracellular environm
Externí odkaz:
https://doaj.org/article/b8b4aa2087944ec6a832ae177a0e0071