Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Robert P. Gomez"'
Autor:
Sarah L. Huszar, Thomas W. Rosahl, Sophie Parmentier-Batteur, H. Fauré, Thomas J. Tucker, Craig A. Stump, Emannuel Le Poul, Richard Hargreaves, Brian C. Magliaro, Xu-Fang Zhang, Neville J. Anthony, Thomas Forest, Theresa M. Williams, Jason M. Uslaner, Nathalie Lambeng, Julie A. O'Brien, Robert P. Gomez, Robert M. Tynebor, Peter H. Hutson, Sonia Poli, Jean-Philippe Rocher, Britta A. Mattson, Karsten Menzel
Publikováno v:
Neuropharmacology. 82:161-173
Previous work has suggested that activation of mGlu5 receptor augments NMDA receptor function and thereby may constitute a rational approach addressing glutamate hypofunction in schizophrenia and a target for novel antipsychotic drug development. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44024f123a60505445bf06fd0e251b96
https://doi.org/10.1016/j.neuropharm.2012.12.003
https://doi.org/10.1016/j.neuropharm.2012.12.003
Autor:
Robert P. Gomez, Ming-Tain Lai, Jay A. Grobler, Peter J. Felock, Renee Hrin, Meiqing Lu, Daria J. Hazuda, Michael D. Miller, Philip M. McKenna, Vandna Munshi, Georgia B. McGaughey, Youwei Yan, Neville J. Anthony, Sanjeev Munshi, Theresa M. Williams, Ying-Jie Wang
Publikováno v:
Antimicrobial Agents and Chemotherapy. 56:3324-3335
MK-6186 is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) which displays subnanomolar potency against wild-type (WT) virus and the two most prevalent NNRTI-resistant RT mutants (K103N and Y181C) in biochemical assays. In addition, it s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::561b3281c8a4f7dea6d1c2cf6e7309a2
https://doi.org/10.1128/aac.00102-12
https://doi.org/10.1128/aac.00102-12
Autor:
Yuexia Liang, Daniel DeStefano, Samson M. Jolly, Georgia B. McGaughey, Joe P. Vacca, Bang-Lin Wan, Michael W. Miller, Robert P. Gomez, Youwei Yan, Sinoeun Touch, Neville J. Anthony, Robert M. Tynebor, Ming-Tain Lai, Rosa I. Sanchez, Vandna Munshi, Thomas J. Tucker, Theresa M. Williams, Peter J. Felock, Brenda Paton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7344-7350
Next generation NNRTIs are sought which possess both broad spectrum antiviral activity against key mutant strains and a high genetic barrier to the selection of new mutant viral strains. Pyridones were evaluated as an acyclic conformational constrain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b31490ebe226d08d8789ee8cd109a3
https://doi.org/10.1016/j.bmcl.2011.10.027
https://doi.org/10.1016/j.bmcl.2011.10.027
Autor:
Nancy E. Kohl, Charles A. Omer, Michael W. Conner, Neville J. Anthony, Joseph P. Davide, S. Jane Desolms, Elizabeth A. Giuliani, Robert P. Gomez, Samuel L. Graham, Kelly Hamilton, Laurence K. Handt, George D. Hartman, Kenneth S. Koblan, Astrid M. Kral, Patricia J. Miller, Scott D. Mosser, Timothy J. O'Neill, Elaine Rands, Michael D. Schaber, Jackson B. Gibbs, Allen Oliff
Publikováno v:
Nature Medicine. 1:792-797
For Ras oncoproteins to transform mammalian cells, they must be post-translationally modified with a farnesyl group in a reaction catalysed by the enzyme farnesyl-protein transferase (FPTase). Inhibitors of FPTase have therefore been proposed as anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0382a1f38fff17a314a1bd3e4fdea51b
https://doi.org/10.1038/nm0895-792
https://doi.org/10.1038/nm0895-792
Publikováno v:
Tetrahedron Letters. 36:3821-3824
The synthesis of methylene-oxy dipeptide isosteres has been achieved by stereoselective functionalisation of the acylmorpholinone 3 .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f7bd7310916be2f29c013980f2163d9
https://doi.org/10.1016/0040-4039(95)00687-8
https://doi.org/10.1016/0040-4039(95)00687-8
Autor:
Lee Ta Jyh, Neville J. Anthony, Robert P. Gomez, S D Mosser, Michael W. Conner, Nancy E. Kohl, W. J. Holtz, F R Wilson, E A Giuliani, S J deSolms
Publikováno v:
Proceedings of the National Academy of Sciences. 91:9141-9145
The posttranslational addition of a farnesyl moiety to the Ras oncoprotein is essential for its transforming activity. Cell-active inhibitors of the enzyme that catalyzes this reaction, protein farnesyltransferase, have been shown to selectively bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea781f34fb12e3278cbb8f3cb8222043
https://doi.org/10.1073/pnas.91.19.9141
https://doi.org/10.1073/pnas.91.19.9141
Autor:
Michael W. Miller, Yuexia Liang, Ming-Tain Lai, Georgia B. McGaughey, Bang-Lin Wan, Maricel Torrent, Rosa I. Sanchez, Daniel J. DiStefano, John C. Reid, Peter J. Felock, Robert P. Gomez, Theresa M. Williams, Brenda Paton, Joseph P. Vacca, Youwei Yan, Jessica A. Flynn, Samson J. Jolly, Neville J. Anthony, Vandna Munshi
Publikováno v:
Journal of medicinal chemistry. 54(22)
Highly active antiretroviral therapy (HAART) significantly reduces human immunodeficiency virus (HIV) viral load and has led to a dramatic decrease in acquired immunodeficiency syndrome (AIDS) related mortality. Despite this success, there remains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff26cd030c5ddb85bf18b3966df6d9a
https://pubmed.ncbi.nlm.nih.gov/21985673
https://pubmed.ncbi.nlm.nih.gov/21985673
Publikováno v:
ChemInform. 26
The synthesis of methylene-oxy dipeptide isosteres has been achieved by stereoselective functionalisation of the acylmorpholinone 3 .
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::804cc7e87380c68f636321fd76b69fba
https://doi.org/10.1002/chin.199537232
https://doi.org/10.1002/chin.199537232
Autor:
William A. Schleif, Lori J. Gabryelski, Amanda R. Cortes, James P. Guare, Steven D. Young, I.-W. Chen, John S. Wai, Samson M. Jolly, Daria J. Hazuda, Gregory Moyer, Robert P. Gomez, Peter J. Felock, Lixia Jin, Neville J. Anthony, Kara A. Stillmock, Joseph P. Vacca
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(11)
A series of 5-amino derivatives of 8-hydroxy[1,6]-naphthyridine-7-carboxamide exhibiting sub-micromolar potency against replication of HIV-1 in cell culture was identified. One of these analogs, compound 12, displayed excellent pharmacokinetic proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7feb58d35723cf8ce956a531f37f26b
https://pubmed.ncbi.nlm.nih.gov/16554152
https://pubmed.ncbi.nlm.nih.gov/16554152
Autor:
Daria J. Hazuda, John S. Wai, Lynda Tussey, Neville J. Anthony, Geethanjali Dornadula, Michael D. Miller, John W. Shiver, Joseph P. Vacca, Sherri L. Motzel, Lixia Jin, Robert M. Danovich, Marc V. Witmer, Larry Handt, James P. Guare, Danilo R. Casimiro, Steven D. Young, Lori S. Gabryelski, Hilton J. Klein, Robert P. Gomez, Keith A. Wilson, William A. Schleif, Emilio A. Emini
Publikováno v:
Science (New York, N.Y.). 305(5683)
We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV) 89.6P. When initiated before CD4 cell depletion, L-870812 therapy mediated a sustained supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d00fdcc48d33695f331e19fc6a1f349
https://pubmed.ncbi.nlm.nih.gov/15247437
https://pubmed.ncbi.nlm.nih.gov/15247437