Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Robert P. Foster"'
Publikováno v:
PLoS ONE, Vol 19, Iss 4, p e0301711 (2024)
A family of Peptidyl-prolyl isomerases (PPIases), called Cyclophilins, localize to numerous intracellular and extracellular locations where they contribute to a variety of essential functions. We previously reported that non-immunosuppressive pan-cyc
Externí odkaz:
https://doaj.org/article/155fcb9d4a9f4cb581ddc2467fa1681a
Autor:
Winston T Stauffer, Asha Z Goodman, Michael Bobardt, Daren R Ure, Robert T Foster, Philippe Gallay
Publikováno v:
PLoS ONE, Vol 19, Iss 3, p e0298211 (2024)
Cyclophilins are a diverse family of peptidyl-prolyl isomerases (PPIases) of importance in a variety of essential cellular functions. We previously reported that the pan-cyclophilin inhibitor drug reconfilstat (CRV431) decreased disease in mice under
Externí odkaz:
https://doaj.org/article/19d47efbe885491990eac842c64e51d5
Autor:
Kanae Nishii, Michael Möller, Robert G. Foster, Laura L. Forrest, Nathan Kelso, Sadie Barber, Caroline Howard, Michelle L. Hart
Publikováno v:
Plant Methods, Vol 19, Iss 1, Pp 1-11 (2023)
Abstract Background PacBio HiFi sequencing provides highly accurate long-read sequencing datasets which are of great advantage for whole genome sequencing projects. One limitation of the method is the requirement for high quality, high molecular weig
Externí odkaz:
https://doaj.org/article/07a613fdc26b40b5a6c8eceadc512621
Autor:
Mariana Diel de Amorim, Lynn Dong, Michael Byron, Robert A. Foster, Claudia Klein, Monique Saleh, Tarek Saleh, Claire Card
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Oxytocin is a hormone with functions in: reproduction, maternal bonding, milk ejection, and feeding/social behavior, and is reported to be present in a variety of tissues. Our goal is to characterize oxytocin and leucyl and cystinyl aminopep
Externí odkaz:
https://doaj.org/article/a407ef7c1c074a4e9fb42ff55a47d069
Autor:
Stephen A. Harrison, Patrick R. Mayo, Todd M. Hobbs, Carlos Canizares, Erin P. Foster, Caroline Zhao, Daren R. Ure, Daniel J. Trepanier, Jill A. Greytok, Robert T. Foster
Publikováno v:
Hepatology Communications, Vol 6, Iss 12, Pp 3379-3392 (2022)
Abstract Rencofilstat (RCF) demonstrated antifibrotic effects in preclinical models and was safe and well tolerated in Phase 1 studies. The aim of this Phase 2a study was safety, tolerability, pharmacokinetics, and exploration of efficacy biomarkers
Externí odkaz:
https://doaj.org/article/3d1b62b8d5934a7da35bda5d34e3a0aa
Autor:
Stuart W. McKellar, Ivayla Ivanova, Pedro Arede, Rachel L. Zapf, Noémie Mercier, Liang-Cui Chu, Daniel G. Mediati, Amy C. Pickering, Paul Briaud, Robert G. Foster, Grzegorz Kudla, J. Ross Fitzgerald, Isabelle Caldelari, Ronan K. Carroll, Jai J. Tree, Sander Granneman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Regulatory small RNA (sRNA) interact with mRNAs to regulate their stability, transcription, and translation via diverse mechanisms. Here, McKellar et al. apply RNase IIICLASH of multi-drug resistant Staphylococcus aureus under different culture condi
Externí odkaz:
https://doaj.org/article/5c83133778664f04bc823f94397e141e
Autor:
Robert S. Foster, Adrian Fowkes, Alex Cayley, Andrew Thresher, Anne-Laure D. Werner, Chris G. Barber, Grace Kocks, Rachael E. Tennant, Richard V. Williams, Steven Kane, Susanne A. Stalford
Publikováno v:
Genes and Environment, Vol 42, Iss 1, Pp 1-9 (2020)
Abstract The use of in silico predictions for the assessment of bacterial mutagenicity under the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) M7 guideline is recommended when two complement
Externí odkaz:
https://doaj.org/article/1833385354894e5fa7b556bfdcbab733
Autor:
Alexander Mackintosh, Dominik R Laetsch, Tobias Baril, Robert G Foster, Vlad Dincă, Roger Vila, Alexander Hayward, Konrad Lohse
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 12, Iss 6 (2022)
AbstractThe lesser marbled fritillary, Brenthis inoBrenthis inoBrenthis ino
Externí odkaz:
https://doaj.org/article/97790ba4d77a4f7eb75a41eda38a6368
Autor:
Vanessa P. Houde, Sara Donzelli, Andrea Sacconi, Sandra Galic, Joanne A. Hammill, Jonathan L. Bramson, Robert A. Foster, Theodoros Tsakiridis, Bruce E. Kemp, Giuseppe Grasso, Giovanni Blandino, Paola Muti, Gregory R. Steinberg
Publikováno v:
Molecular Oncology, Vol 11, Iss 9, Pp 1143-1155 (2017)
The AMP‐activated protein kinase (AMPK) is a heterotrimeric protein complex that is an important sensor of cellular energy status. Reduced expression of the AMPK β1 isoform has been linked to reduced survival in different cancers, but whether this
Externí odkaz:
https://doaj.org/article/2f7ed24678f9476889ae039ad8531ce5
Publikováno v:
Journal of Pharmacy & Pharmaceutical Sciences, Vol 21, Iss 1s (2018)
PURPOSE: The objective of this study was to develop a self-microemulsifying drug delivery system (SMEDDS) formulation for the oral delivery of CRV431, a non-immunosuppressive analogue of cyclosporine A. Relative to cyclosporine A, CRV431 is poorly so
Externí odkaz:
https://doaj.org/article/26108c1c0720412b98a268ee461267f1