Výsledky vyhledávání - "Robert P. Filik"

Anti-Beckwith stereoselectivity in amidyl radical cyclisations: Bu3SnH-mediated 5-exo-trig acyl mode cyclisation of 2-substituted pent-4-enamide radicals

Autor: Robert P. Filik, Andrew J. Clark, Gerard Hugh Thomas, John A. Sherringham

Publikováno v: Tetrahedron Letters. 54:4094-4097

2-Substituted amidyl radicals derived from 8a–d and 9a–d undergo acyl mode 5-exo-trig cyclisation to give 3,5-trans pyrrolidinones 11a–d and 14a–d as the major products in low diastereoselectivity (de = 9–36%). The steric nature of the nitr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a2000f7437a86369dd5e057d687918a
https://doi.org/10.1016/j.tetlet.2013.05.109

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Atom transfer radical cyclisations of activated and unactivated N-allylhaloacetamides and N-homoallylhaloacetamides using chiral and non-chiral copper complexes

Autor: Andrew J. Clark, Nicola A. Hunt, Dominique Lastecoueres, Robert J. Deeth, Jean-Baptiste Verlhac, Robert P. Filik, Hathaichanuk Wongtap, Floryan De Campo, Sylvain Gatard, Gerard Hugh Thomas

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :671-680

Activated N-tosyl-2,2,2-trichloroacetamide 6a, N-benzyl-2,2,2-trichloroacetamide 6d, 2,2-dichloroacetamides 6b–c and 6e–f and 2-monohaloacetamides 11a–g undergo efficient 5-exo atom transfer radical cyclisations at room temperature mediated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3ae0c1ac185d78ff509e0be5667b2412
https://doi.org/10.1039/a909666c

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Ligand geometry effects in copper mediated atom transfer radical cyclisations

Autor: Gerard Hugh Thomas, Andrew J. Clark, Robert P. Filik

Publikováno v: Tetrahedron Letters. 40:4885-4888

The relative rate of copper (I) mediated atom transfer radical cyclisation of ( 11 ) with a range of ligands at room temperature has been screened. The most active ligands were found to be multidentate amine ligands ( 6–7 ).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::704a965959cea20ec405739acc6e66f5
https://doi.org/10.1016/s0040-4039(99)00903-x

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N-alkyl-2-pyridylmethanimines as tuneable alternatives to bipyridine ligands in copper mediated atom transfer radical cyclisation

Autor: David J. Duncalf, Andrew J. Clark, Hathaichanuk Wongtap, David M. Haddleton, Robert P. Filik, Gerard Hugh Thomas

Publikováno v: Tetrahedron Letters. 40:3807-3810

Copper halide complexes of N-alkyl-2-pyridylmethanimines ( 3, 11–14 ) catalyse atom transfer radical cyclisation reactions of activated ( 6a-b ) and unactivated α-haloallylacetamides ( 9 ) at room temperature.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbc0eb36ebab13ddd30d081af83307bc
https://doi.org/10.1016/s0040-4039(99)00533-x

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Rearrangements of activated O-acyl hydroxamic acid derivatives

Autor: Robert P. Filik, Gerry H. Thomas, Yasair S.S. Al-Faiyz, Joanne L. Peacock, Andrew J. Clark

Publikováno v: Tetrahedron Letters. 39:1269-1272

O-acyl hydroxamic acid derivatives ( 1a-d, 6a-c, 8a-b ) undergo base catalysed rearrangement to give secondary 2-acyloxyamides ( 4a-d, 7a-c, 9a-b ) in moderate to excellent yields (56–98%).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bf3420a88beb5f02290a6920dad4007
https://doi.org/10.1016/s0040-4039(97)10773-0

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ChemInform Abstract: Rearrangements of Activated O-Acyl Hydroxamic Acid Derivatives

Autor: Andrew J. Clark, Joanne L. Peacock, Robert P. Filik, Yasair S.S. Al-Faiyz, Gerry H. Thomas

Publikováno v: ChemInform. 29

O-acyl hydroxamic acid derivatives ( 1a-d, 6a-c, 8a-b ) undergo base catalysed rearrangement to give secondary 2-acyloxyamides ( 4a-d, 7a-c, 9a-b ) in moderate to excellent yields (56–98%).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::357ff3fca8b58a89f7d244b6894e2c47
https://doi.org/10.1002/chin.199820122

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