Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Robert P. Fagan"'
Autor:
Jessica E. Buddle, Robert P. Fagan
Publikováno v:
Virulence, Vol 14, Iss 1 (2023)
ABSTRACT Clostridioides difficile is the most common cause of nosocomial antibiotic-associated diarrhea, and is responsible for a spectrum of diseases characterized by high levels of recurrence, morbidity, and mortality. Treatment is complex, since a
Externí odkaz:
https://doaj.org/article/dfb2a56612714bdfa6f8c2c51c9c45d0
Autor:
Michael J. Ormsby, Filipa Vaz, Joseph A. Kirk, Anna Barwinska-Sendra, Jennifer C. Hallam, Paola Lanzoni-Mangutchi, John Cole, Roy R. Chaudhuri, Paula S. Salgado, Robert P. Fagan, Gillian R Douce
Publikováno v:
PLoS Pathogens, Vol 19, Iss 6 (2023)
Clostridioides difficile is responsible for substantial morbidity and mortality in antibiotically-treated, hospitalised, elderly patients, in which toxin production correlates with diarrhoeal disease. While the function of these toxins has been studi
Externí odkaz:
https://doaj.org/article/c86b98dea6594503baae7233de32c14f
Autor:
Paola Lanzoni-Mangutchi, Oishik Banerji, Jason Wilson, Anna Barwinska-Sendra, Joseph A. Kirk, Filipa Vaz, Shauna O’Beirne, Arnaud Baslé, Kamel El Omari, Armin Wagner, Neil F. Fairweather, Gillian R. Douce, Per A. Bullough, Robert P. Fagan, Paula S. Salgado
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The S-layer is a two-dimensional protein array that covers the cell surface of many bacteria and archaea. Here, the authors use high-resolution X-ray crystallography and electron microscopy to provide detailed insights into S-layer organisation and a
Externí odkaz:
https://doaj.org/article/060e552494ad40e5a8e3a8037d7d898a
Autor:
Wichuda Phothichaisri, Surang Chankhamhaengdecha, Tavan Janvilisri, Jirayu Nuadthaisong, Tanaporn Phetruen, Robert P. Fagan, Sittinan Chanarat
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 2 (2022)
ABSTRACT Endolysin is a phage-encoded cell-wall hydrolase which degrades the peptidoglycan layer of the bacterial cell wall. The enzyme is often expressed at the late stage of the phage lytic cycle and is required for progeny escape. Endolysins of ba
Externí odkaz:
https://doaj.org/article/ec0fa2d1ad5d49bebc84cd44cc98217b
Autor:
Thamarai K. Janganan, Nic Mullin, Ainhoa Dafis-Sagarmendi, Jason Brunt, Svetomir B. Tzokov, Sandra Stringer, Anne Moir, Roy R. Chaudhuri, Robert P. Fagan, Jamie K. Hobbs, Per A. Bullough
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT Spores, the infectious agents of many Firmicutes, are remarkably resilient cell forms. Even distant relatives can have similar spore architectures although some display unique features; they all incorporate protective proteinaceous envelopes
Externí odkaz:
https://doaj.org/article/41d109989bd9469a8966c01fd5b8668e
Autor:
Marcin Dembek, Lars Barquist, Christine J. Boinett, Amy K. Cain, Matthew Mayho, Trevor D. Lawley, Neil F. Fairweather, Robert P. Fagan
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT Clostridium difficile is the most common cause of antibiotic-associated intestinal infections and a significant cause of morbidity and mortality. Infection with C. difficile requires disruption of the intestinal microbiota, most commonly by
Externí odkaz:
https://doaj.org/article/e216797dfeeb4627b710e0978c35925a
Autor:
Alexia L. M. Royer, Andrew A. Umansky, Marie-Maude Allen, Julian R. Garneau, Maicol Ospina-Bedoya, Joseph A. Kirk, Gregory Govoni, Robert P. Fagan, Olga Soutourina, Louis-Charles Fortier
Publikováno v:
Microbiology Spectrum. 11
Phage therapy represents an interesting alternative to treat Clostridioides difficile infections because, contrary to antibiotics, most phages are highly species specific, thereby sparing the beneficial gut microbes that protect from infection. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1cc7704b20e69fae14f2e380db6da1
https://doi.org/10.1128/spectrum.03894-22
https://doi.org/10.1128/spectrum.03894-22
Autor:
Jessica E, Buddle, Robert P, Fagan
Publikováno v:
Virulence. 14(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6d6a2217cfd9655c6f3e080f7010f6a2
https://pubmed.ncbi.nlm.nih.gov/36419222
https://pubmed.ncbi.nlm.nih.gov/36419222
Autor:
Michael J. Ormsby, Filipa Vaz, Joseph A. Kirk, Anna Barwinska-Sendra, Jennifer C. Hallam, Paola Lanzoni-Mangutchi, John Cole, Roy R. Chaudhuri, Paula S. Salgado, Robert P. Fagan, Gillian R Douce
Clostridioides difficileis responsible for substantial morbidity and mortality in antibiotically-treated, hospitalised, elderly patients, in which toxin production correlates with diarrhoeal disease. While the function of these toxins has been studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b1d4dd2aa6da04add1e8f03717be880
https://doi.org/10.1101/2022.11.22.517470
https://doi.org/10.1101/2022.11.22.517470
Autor:
Alexia L.M. Royer, Andrew A. Umansky, Marie-Maude Allen, Julian R. Garneau, Maicol Ospina-Bedoya, Joseph A. Kirk, Gregory Govoni, Robert P. Fagan, Olga Soutourina, Louis-Charles Fortier
Therapeutic bacteriophages (phages) are being considered as alternatives in the fight against Clostridioides difficile infections. To be efficient, phages should have a wide host range, but the lack of knowledge about the cell receptor used by C. dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9928e28c3e85dbccfffc7785ac7f53c
https://doi.org/10.1101/2022.09.19.508581
https://doi.org/10.1101/2022.09.19.508581