Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Robert P Mohney"'
Autor:
Cristina Menni, Jialing Zhu, Caroline I Le Roy, Olatz Mompeo, Kristin Young, Casey M. Rebholz, Elizabeth Selvin, Kari E. North, Robert P Mohney, Jordana T Bell, Eric Boerwinkle, Tim D Spector, Massimo Mangino, Bing Yu, Ana M Valdes
Publikováno v:
Gut Microbes, Vol 11, Iss 6, Pp 1632-1642 (2020)
Type 2 diabetes (T2D) is associated with reduced gut microbiome diversity, although the cause is unclear. Metabolites generated by gut microbes also appear to be causative factors in T2D. We therefore searched for serum metabolites predictive of gut
Externí odkaz:
https://doaj.org/article/09df21ff4f3747d3aebe8eb0d2d893b5
Autor:
James P Shellhammer, Elizabeth Morin-Kensicki, Jacob P Matson, Guowei Yin, Daniel G Isom, Sharon L Campbell, Robert P Mohney, Henrik G Dohlman
Publikováno v:
PLoS Genetics, Vol 13, Iss 5, p e1006829 (2017)
All cells respond to osmotic stress by implementing molecular signaling events to protect the organism. Failure to properly adapt can lead to pathologies such as hypertension and ischemia-reperfusion injury. Mitogen-activated protein kinases (MAPKs)
Externí odkaz:
https://doaj.org/article/e1557cf21e24484d89a2ddd935501880
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187729 (2017)
In order to search for metabolic biomarkers of antihypertensive drug responsiveness, we measured >600 biochemicals in plasma samples of subjects participating in the GENRES Study. Hypertensive men received in a double-blind rotational fashion amlodip
Externí odkaz:
https://doaj.org/article/d5edb2606f6141d9b88f709718adc2d2
Autor:
Michael J Pecaut, Xiao Wen Mao, Denise L Bellinger, Karen R Jonscher, Louis S Stodieck, Virginia L Ferguson, Ted A Bateman, Robert P Mohney, Daila S Gridley
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0174174 (2017)
The Space Shuttle Atlantis launched on its final mission (STS-135) on July 8, 2011. After just under 13 days, the shuttle landed safely at Kennedy Space Center (KSC) for the last time. Female C57BL/6J mice flew as part of the Commercial Biomedical Te
Externí odkaz:
https://doaj.org/article/4dd5a5e13d5e47a280907faaca132817
Autor:
Makoto Harada, Jonathan Adam, Marcela Covic, Jianhong Ge, Stefan Brandmaier, Caroline Muschet, Jialing Huang, Siyu Han, Martina Rommel, Markus Rotter, Margit Heier, Robert P. Mohney, Jan Krumsiek, Gabi Kastenmüller, Wolfgang Rathmann, Zhongmei Zou, Sven Zukunft, Markus F. Scheerer, Susanne Neschen, Jerzy Adamski, Christian Gieger, Annette Peters, Donna P. Ankerst, Thomas Meitinger, Tanya L. Alderete, Martin Hrabe de Angelis, Karsten Suhre, Rui Wang-Sattler
Publikováno v:
Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background Metformin and sodium-glucose-cotransporter-2 inhibitors (SGLT2i) are cornerstone therapies for managing hyperglycemia in diabetes. However, their detailed impacts on metabolic processes, particularly within the citric acid (TCA) c
Externí odkaz:
https://doaj.org/article/5843fb532be04b438b4aad8078618b3c
Autor:
Olga Rafikova, Mary L Meadows, Jason M Kinchen, Robert P Mohney, Emin Maltepe, Ankit A Desai, Jason X-J Yuan, Joe G N Garcia, Jeffrey R Fineman, Ruslan Rafikov, Stephen M Black
Publikováno v:
PLoS ONE, Vol 11, Iss 3, p e0150480 (2016)
There is increasing interest in the potential for metabolic profiling to evaluate the progression of pulmonary hypertension (PH). However, a detailed analysis of the metabolic changes in lungs at the early stage of PH, characterized by increased pulm
Externí odkaz:
https://doaj.org/article/55c5de473c2c4faaa18587933f9f342c
Autor:
Tess Pallister, Amy Jennings, Robert P Mohney, Darioush Yarand, Massimo Mangino, Aedin Cassidy, Alexander MacGregor, Tim D Spector, Cristina Menni
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158568 (2016)
Using dietary biomarkers in nutritional epidemiological studies may better capture exposure and improve the level at which diet-disease associations can be established and explored. Here, we aimed to identify and evaluate reproducibility of novel bio
Externí odkaz:
https://doaj.org/article/5686ac6be2fd44ec903983fb3f34e275
Autor:
Patrick Weinisch, Johannes Raffler, Werner Römisch-Margl, Matthias Arnold, Robert P. Mohney, Manuela J. Rist, Cornelia Prehn, Thomas Skurk, Hans Hauner, Hannelore Daniel, Karsten Suhre, Gabi Kastenmüller
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114416- (2024)
Summary: Metabolism oscillates between catabolic and anabolic states depending on food intake, exercise, or stresses that change a multitude of metabolic pathways simultaneously. We present the HuMet Repository for exploring dynamic metabolic respons
Externí odkaz:
https://doaj.org/article/e3d1619441524c1aa6797b3a00c4a797
Autor:
January Weiner, Shreemanta K Parida, Jeroen Maertzdorf, Gillian F Black, Dirk Repsilber, Anna Telaar, Robert P Mohney, Cordelia Arndt-Sullivan, Christian A Ganoza, Kellen C Faé, Gerhard Walzl, Stefan H E Kaufmann
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40221 (2012)
Although tuberculosis (TB) causes more deaths than any other pathogen, most infected individuals harbor the pathogen without signs of disease. We explored the metabolome of >400 small molecules in serum of uninfected individuals, latently infected he
Externí odkaz:
https://doaj.org/article/474b39caa580462a88ac8ff3bb37dccb
Autor:
Jan Krumsiek, Karsten Suhre, Anne M Evans, Matthew W Mitchell, Robert P Mohney, Michael V Milburn, Brigitte Wägele, Werner Römisch-Margl, Thomas Illig, Jerzy Adamski, Christian Gieger, Fabian J Theis, Gabi Kastenmüller
Publikováno v:
PLoS Genetics, Vol 8, Iss 10, p e1003005 (2012)
Recent genome-wide association studies (GWAS) with metabolomics data linked genetic variation in the human genome to differences in individual metabolite levels. A strong relevance of this metabolic individuality for biomedical and pharmaceutical res
Externí odkaz:
https://doaj.org/article/5e16ddf58c2244ba8fbb7aa973fa8781