Zobrazeno 1 - 10
of 243
pro vyhledávání: '"Robert P Hebbel"'
Autor:
Gregory M Vercellotti, Fatima B Khan, Heather eBechtel, Karl A Nath, Julia eNguyen, Chunseng eChen, Carol M Bruzzone, Graham eBrown, Clifford John Steer, Robert P Hebbel, John D. Belcher
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Hemolysis, oxidative stress, inflammation, vaso-occlusion and organ infarction are hallmarks of sickle cell disease (SCD). We have previously shown that increases in heme oxygenase-1 (HO-1) activity detoxify heme and inhibit vaso-occlusion in transge
Externí odkaz:
https://doaj.org/article/818bdb5b83664b42959d0b07bf3174a3
Autor:
Lucas M Sjeklocha, Chang-Won Park, Phillip Y-P Wong, Mark J Roney, John D Belcher, Dan S Kaufman, Gregory M Vercellotti, Robert P Hebbel, Clifford J Steer
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29110 (2011)
Gene therapy for sickle cell disease will require efficient delivery of a tightly regulated and stably expressed gene product to provide an effective therapy. In this study we utilized the non-viral Sleeping Beauty (SB) transposon system using the SB
Externí odkaz:
https://doaj.org/article/ebda51a9827c44d1a583d970fa5f89f4
Autor:
Subin Jang, Elise F. Palzer, Kyle D. Rudser, Claudia K. Fox, Robert P. Hebbel, Donald R. Dengel, Liming Milbauer, Aaron S. Kelly, Justin R. Ryder
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 22 (2022)
Background Microparticles and endothelial microparticles (EMPs) are implicated in accelerating cardiovascular disease (CVD); however, data in pediatrics are limited. We examined the relationship of microparticles and EMPs with adiposity and subclinic
Externí odkaz:
https://doaj.org/article/731c105b45f94c0280a370288a86acea
Autor:
Joan D. Beckman, Fuad Abdullah, Chunsheng Chen, Rachel Kirchner, Dormarie Rivera-Rodriguez, Zachary M. Kiser, Aithanh Nguyen, Ping Zhang, Julia Nguyen, Robert P. Hebbel, John D. Belcher, Gregory M. Vercellotti
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Heme, released from red blood cells in sickle cell disease (SCD), interacts with toll-like receptor 4 (TLR4) to activate NF-κB leading to the production of cytokines and adhesion molecules which promote inflammation, pain, and vaso-occlusion. In SCD
Externí odkaz:
https://doaj.org/article/8b85be8fe59f4192a1fe566fbb2c75ec
Autor:
Erica G. Soltero, Anna N. Solovey, Robert P. Hebbel, Elise F. Palzer, Justin R. Ryder, Gabriel Q. Shaibi, Micah Olson, Claudia K. Fox, Kyle D. Rudser, Donald R. Dengel, Nicholas G. Evanoff, Aaron S. Kelly
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 1 (2021)
Background Circulating endothelial cells (CECs) reflect early changes in endothelial health; however, the degree to which CEC number and activation is related to adiposity and cardiovascular risk factors in youth is not well described. Methods and Re
Externí odkaz:
https://doaj.org/article/9f6af0ebfbc64fb59b78199706560140
Publikováno v:
Haematologica, Vol 105, Iss 12 (2020)
Externí odkaz:
https://doaj.org/article/b4331afa3599447097a864defebb68e1
Autor:
Robert P. Hebbel, Peng Wei, Liming Milbauer, Michel T. Corban, Anna Solovey, James Kiley, Jack Pattee, Lilach O. Lerman, Wei Pan, Amir Lerman
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 14 (2020)
Background We examined feasibility of a unique approach towards gaining insight into heritable risk for early atherosclerosis: surveying gene expression by endothelial cells from living subjects. Methods and Results Subjects aged
Externí odkaz:
https://doaj.org/article/d576101cb31647759c587fe68362a3d5
Publikováno v:
American Journal of Hematology. 96:1505-1517
A characteristic aspect of the robust, systemic inflammatory state in sickle cell disease is dysfunction of endothelial nitric oxide synthase (eNOS). We identify ten aberrant endothelial cell inputs, present in the specific sickle context, that are k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4504777e51eb86da166e66ab77a10bb6
https://doi.org/10.1002/ajh.26308
https://doi.org/10.1002/ajh.26308
Autor:
Aaron S. Kelly, Elise F. Northrop, Kyle Rudser, Justin R. Ryder, Claudia K. Fox, Liming Milbauer, Robert P. Hebbel, Anna Solovey, Alexander M. Kaizer
Publikováno v:
Biomark Med
Aim: We assessed reproducibility of endothelial microparticles (EMPs) enumeration among youth. Methods & results: Four microparticle (MP) indices – total MP per microliter platelet free plasma (PFP), total EMPs per microliter PFP, percent activated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db34050db473bea0e7b0db562ecf91a5
https://doi.org/10.2217/bmm-2019-0229
https://doi.org/10.2217/bmm-2019-0229
Autor:
Subin Jang, Kyle Rudser, Aaron S. Kelly, Claudia K. Fox, Justin R. Ryder, Robert P. Hebbel, Liming Milbauer, Donald R. Dengel, Elise F. Palzer
Publikováno v:
Circulation. 143
Introduction: Endothelial activation represents one of the earliest signs of the atherosclerotic process. Microparticles (MPs) in plasma, particularly endothelial MPs (EMPs) are reproducible biomarkers of endothelial dysfunction with a simple blood d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d302a4f1758d6d681280ebd38c74868
https://doi.org/10.1161/circ.143.suppl_1.p031
https://doi.org/10.1161/circ.143.suppl_1.p031