Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Robert P, Sebra"'
Autor:
Li Wang, Robert P. Sebra, John P. Sfakianos, Kimaada Allette, Wenhui Wang, Seungyeul Yoo, Nina Bhardwaj, Eric E. Schadt, Xin Yao, Matthew D. Galsky, Jun Zhu
Publikováno v:
Genome Medicine, Vol 12, Iss 1, Pp 1-22 (2020)
Abstract Background Patient stratification based on molecular subtypes is an important strategy for cancer precision medicine. Deriving clinically informative cancer molecular subtypes from transcriptomic data generated on whole tumor tissue samples
Externí odkaz:
https://doaj.org/article/e24305d211b74c32bf80313f7711dc44
Autor:
Kelsi A. Lindblad, Jananan S. Pathmanathan, Sandrine Moreira, John R. Bracht, Robert P. Sebra, Elizabeth R. Hutton, Laura F. Landweber
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Whole-genome shotgun sequencing, which stitches together millions of short sequencing reads into a single genome, ushered in the era of modern genomics and led to a rapid expansion of the number of genome sequences available. Neve
Externí odkaz:
https://doaj.org/article/7a52452939564bb5b410e4257bc55494
Autor:
H. Soon Gweon, Liam P. Shaw, Jeremy Swann, Nicola De Maio, Manal AbuOun, Rene Niehus, Alasdair T. M. Hubbard, Mike J. Bowes, Mark J. Bailey, Tim E. A. Peto, Sarah J. Hoosdally, A. Sarah Walker, Robert P. Sebra, Derrick W. Crook, Muna F. Anjum, Daniel S. Read, Nicole Stoesser, on behalf of the REHAB consortium
Publikováno v:
Environmental Microbiome, Vol 14, Iss 1, Pp 1-15 (2019)
Abstract Background Shotgun metagenomics is increasingly used to characterise microbial communities, particularly for the investigation of antimicrobial resistance (AMR) in different animal and environmental contexts. There are many different approac
Externí odkaz:
https://doaj.org/article/0d44895d887e4f3a9d6d056e7219808b
Autor:
Peter E. Warburton, Robert P. Sebra
Publikováno v:
Annual Review of Genomics and Human Genetics. 24
DNA sequencing has revolutionized medicine over recent decades. However, analysis of large structural variation and repetitive DNA, a hallmark of human genomes, has been limited by short-read technology, with read lengths of 100–300 bp. Long-read s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6c41a7b3c49bb2babf63b8352c1a6bcb
https://doi.org/10.1146/annurev-genom-101722-103045
https://doi.org/10.1146/annurev-genom-101722-103045
Autor:
Manish Gala, Paul Lacaze, John J. McNeil, Robyn L. Woods, Eric Schadt, Finlay Macrae, Anne M. Murray, Robert P. Sebra, Suzanne E. Mahady, Suzanne G. Orchard, Peter Gibbs, Andrew T. Chan, Minyi Lee, Jing Xie, Moeen Riaz, Jonathan M. Downie
Supplementary Figure from Incident Cancer Risk and Signatures Among Older MUTYH Carriers: Analysis of Population-Based and Genomic Cohorts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5c0688dc496ee06d61cf2bbb680860
https://doi.org/10.1158/1940-6207.22533314
https://doi.org/10.1158/1940-6207.22533314
Autor:
Manish Gala, Paul Lacaze, John J. McNeil, Robyn L. Woods, Eric Schadt, Finlay Macrae, Anne M. Murray, Robert P. Sebra, Suzanne E. Mahady, Suzanne G. Orchard, Peter Gibbs, Andrew T. Chan, Minyi Lee, Jing Xie, Moeen Riaz, Jonathan M. Downie
MUTYH carriers have an increased colorectal cancer risk in case–control studies, with loss of heterozygosity (LOH) as the presumed mechanism. We evaluated cancer risk among carriers in a prospective, population-based cohort of older adults. In addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4606f4b22c1507d7d9100fee3be2dedb
https://doi.org/10.1158/1940-6207.c.6547022.v1
https://doi.org/10.1158/1940-6207.c.6547022.v1
Autor:
Matthew D. Galsky, Jun Zhu, Nina Bhardwaj, Padmanee Sharma, Eric Schadt, Xin Yao, Keziban Unsal-Kacmaz, Megan Wind-Rotolo, Peter M. Szabo, William K. Oh, Peter Wiklund, Sudeh Izadmehr, Austin Hake, Sacha Gnjatic, Adam M. Farkas, Robert P. Sebra, Amir Horowitz, Guray Akturk, Kristin G. Beaumont, John P. Sfakianos, Li Wang
Purpose:To define dominant molecular and cellular features associated with PD-1/PD-L1 blockade resistance in metastatic urothelial cancer.Experimental Design:We pursued an unbiased approach using bulk RNA sequencing data from two clinical trials to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172a51184276f191649cafbed4713694
https://doi.org/10.1158/1078-0432.c.6530757.v1
https://doi.org/10.1158/1078-0432.c.6530757.v1
Autor:
Rachael L Hardison, Alistair Harrison, Rachel M Wallace, Derek R Heimlich, Meghan E O'Bryan, Robert P Sebra, Heather W Pinkett, Sheryl S Justice, Kevin M Mason
Publikováno v:
PLoS Pathogens, Vol 14, Iss 10, p e1007355 (2018)
Bacterial pathogens must sense, respond and adapt to a myriad of dynamic microenvironmental stressors to survive. Adaptation is key for colonization and long-term ability to endure fluctuations in nutrient availability and inflammatory processes. We
Externí odkaz:
https://doaj.org/article/071880675a8f486dbd0431d0e9a41899
Autor:
Seung Yub Han, Alesia Antoine, David Howard, Bryant Chang, Woo Sung Chang, Matthew Slein, Gintaras Deikus, Sofia Kossida, Patrice Duroux, Marie-Paule Lefranc, Robert P. Sebra, Melissa L. Smith, Ismael Ben F. Fofana
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The simian immunodeficiency virus (SIV)/macaque model of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome pathogenesis is critical for furthering our understanding of the role of antibody responses in the prevention of HIV infect
Externí odkaz:
https://doaj.org/article/d31146ce90f14af4af6e11d84997c819
Autor:
Marion Déjosez, Arturo Marin, Graham M. Hughes, Ariadna E. Morales, Carlos Godoy-Parejo, Jonathan Gray, Yiren Qin, Arun A. Singh, Hui Xu, Javier Juste, Carlos Ibáñez, Kris M. White, Romel Rosales, Nancy J. Francoeur, Robert P. Sebra, Dominic Alcock, Sébastien J. Puechmaille, Andrzej Pastusiak, Simon D.W. Frost, Michael Hiller, Richard A. Young, Emma C. Teeling, Adolfo García-Sastre, Thomas P. Zwaka
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Bats have evolved features unique amongst mammals, including flight, laryngeal echolocation, and certain species have been shown to have a unique immune response that may enable them to tolerate viruses such as SARS-CoVs, MERS-CoVs, Nipah, and Marbur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5ff677d6d0a24a155cfd059e23f6a6c
https://doi.org/10.1101/2022.09.23.509261
https://doi.org/10.1101/2022.09.23.509261