Zobrazeno 1 - 10
of 351
pro vyhledávání: '"Robert P, Mecham"'
Autor:
Chien-Jung Lin, Campbell Keating, Robyn Roth, Yasar Caliskan, Mustafa Nazzal, Vernat Exil, Richard DiPaolo, Divya Ratan Verma, Kishore Harjai, Mohamed Zayed, Chieh-Yu Lin, Robert P. Mecham, Ajay K. Jain
Publikováno v:
Journal of Cardiovascular Development and Disease, Vol 11, Iss 11, p 349 (2024)
Thoracic and abdominal aortic aneurysms (TAAs and AAAs, respectively) share morphological features but have distinct clinical and hereditary characteristics. Studies using bulk RNA comparisons revealed distinct patterns of gene expression in human TA
Externí odkaz:
https://doaj.org/article/7c93a965813f4bd1b04f6f20dd7356c4
Autor:
Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
SVEP1 is linked to numerous human diseases, though its disease-promoting mechanism has remained unclear. Here, the authors identify SVEP1 as a ligand for the orphan receptor PEAR1 and provide insight into the role of this interaction in cardiovascula
Externí odkaz:
https://doaj.org/article/00a5662500fa4216a282bb3c8ddfa931
Autor:
Claire A. Ruddiman, Richard Peckham, Melissa A. Luse, Yen-Lin Chen, Maniselvan Kuppusamy, Bruce A. Corliss, P. Jordan Hall, Chien-Jung Lin, Shayn M. Peirce, Swapnil K. Sonkusare, Robert P. Mecham, Jessica E. Wagenseil, Brant E. Isakson
Publikováno v:
JCI Insight, Vol 8, Iss 9 (2023)
Lipid regulation of ion channels is largely explored using in silico modeling with minimal experimentation in intact tissue; thus, the functional consequences of these predicted lipid-channel interactions within native cellular environments remain el
Externí odkaz:
https://doaj.org/article/7e3053ea3fba4f4ebcd0e85d89274a84
Autor:
Jared S. Elenbaas, Upasana Pudupakkam, Katrina J. Ashworth, Chul Joo Kang, Ved Patel, Katherine Santana, In-Hyuk Jung, Paul C. Lee, Kendall H. Burks, Junedh M. Amrute, Robert P. Mecham, Carmen M. Halabi, Arturo Alisio, Jorge Di Paola, Nathan O. Stitziel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/7c4ce03f276947c5a06906eedf5397a8
Autor:
Amanda L. Mohabeer, Jeffrey T. Kroetsch, Meghan McFadden, Negin Khosraviani, Thomas J. Broekelmann, Guangpei Hou, Hangjun Zhang, Yu-Qing Zhou, Minyao Wang, Anthony O. Gramolini, Robert P. Mecham, Scott P. Heximer, Steffen-Sebastian Bolz, Michelle P. Bendeck
Publikováno v:
Matrix Biology Plus, Vol 12, Iss , Pp 100085- (2021)
Arterial stiffening is a significant predictor of cardiovascular disease development and mortality. In elastic arteries, stiffening refers to the loss and fragmentation of elastic fibers, with a progressive increase in collagen fibers. Type VIII coll
Externí odkaz:
https://doaj.org/article/1c0e6c4c6c564815be877bd0f3ad21d7
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
There is ample evidence supporting a role for angiotensin II type 2 receptor (AT2R) in counterbalancing the effects of angiotensin II (ang II) through the angiotensin II type 1 receptor by promoting vasodilation and having anti-inflammatory effects.
Externí odkaz:
https://doaj.org/article/283e70f0205542cf9439b02d48b8b6a9
Publikováno v:
Tissue Engineering Part A. 29:187-199
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2504e2da626b2add2459ffca44ec987f
https://doi.org/10.1089/ten.tea.2022.0170
https://doi.org/10.1089/ten.tea.2022.0170
Autor:
Haixia Zhang, Alex Hanson, Tobias Scherf de Almeida, Christopher Emfinger, Conor McClenaghan, Theresa Harter, Zihan Yan, Paige E. Cooper, G. Schuyler Brown, Eric C. Arakel, Robert P. Mecham, Atilla Kovacs, Carmen M. Halabi, Blanche Schwappach, Maria S. Remedi, Colin G. Nichols
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Cantu syndrome (CS) is caused by gain-of-function (GOF) mutations in pore-forming (Kir6.1, KCNJ8) and accessory (SUR2, ABCC9) ATP-sensitive potassium (KATP) channel subunits, the most common mutations being SUR2[R1154Q] and SUR2[R1154W], carried by a
Externí odkaz:
https://doaj.org/article/49205ba65db14c0c92f39428e2cf79af
Autor:
Bridget M. Brengle, Michelle Lin, Robyn A. Roth, Kara D. Jones, Jessica E. Wagenseil, Robert P. Mecham, Carmen M. Halabi
Publikováno v:
Matrix Biology. 117:1-14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b653fa1a8ecdb7be906ddc7f01d023b9
https://doi.org/10.1016/j.matbio.2023.02.003
https://doi.org/10.1016/j.matbio.2023.02.003
Autor:
Nuria Coll-Bonfill, Urvashi Mahajan, Elena V. Shashkova, Chien-Jung Lin, Robert P. Mecham, Susana Gonzalo
Publikováno v:
GeroScience
Hutchinson-Gilford progeria syndrome is a premature aging disease caused by LMNA gene mutation and the production of a truncated prelamin A protein “progerin” that elicits cellular and organismal toxicity. Progerin accumulates in the vasculature,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b35e7260ba68782482e588fec50d5e
https://doi.org/10.1007/s11357-022-00694-1
https://doi.org/10.1007/s11357-022-00694-1