Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Robert P, Lyon"'
Autor:
Peter D. Senter, Robert P. Lyon, Weiping Zeng, Margo C. Zaval, Abbie Wong, Andrew B. Waight, Michelle L. Ulrich, Jessica K. Simmons, Paul G. Pittman, Jay C. Nix, Jason Neale, David W. Meyer, Luke V. Loftus, Fu Li, Steven Jin, Julia H. Cochran, Martha E. Anderson, Kathleen C. Olivas, Christopher S. Neumann
Supplemental tables and figures referenced in main text: Table S1 - Crystallography data collection and refinement statistics; Table S2 - ADC characterization data; Figure S1 - ADC plasma stability data; Figure S2 - Time course for ADC activity in vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db82a176dff235f814043a7bfa28d04
https://doi.org/10.1158/1535-7163.22505812
https://doi.org/10.1158/1535-7163.22505812
Autor:
Robert P. Lyon, Peter D. Senter, Erica E. McKinney, Jessica K. Simmons, Michelle L. Ulrich, Ivan J. Stone, Martha E. Anderson, Jamie B. Miyamoto, Nicole M. Okeley, Svetlana O. Doronina, Joshua H. Hunter, Scott C. Jeffrey, Joseph Z. Hamilton, Patrick J. Burke
Hematology paramters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34c95636a4c8b62c90712d22da689577
https://doi.org/10.1158/1535-7163.22508644.v1
https://doi.org/10.1158/1535-7163.22508644.v1
Autor:
Scott C. Jeffrey, Robert P. Lyon, Peter D. Senter, Andrew B. Waight, Kim K. Emmerton, Christopher I. Leiske, Holden W.H. Lai, Thomas A. Pires, Joseph Z. Hamilton, Patrick J. Burke
rat tolerability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e1ea15100603c968c5a7e8fc62cc703
https://doi.org/10.1158/1535-7163.22505311
https://doi.org/10.1158/1535-7163.22505311
Autor:
Robert P. Lyon, Peter D. Senter, Erica E. McKinney, Jessica K. Simmons, Michelle L. Ulrich, Ivan J. Stone, Martha E. Anderson, Jamie B. Miyamoto, Nicole M. Okeley, Svetlana O. Doronina, Joshua H. Hunter, Scott C. Jeffrey, Joseph Z. Hamilton, Patrick J. Burke
SEC overlays of ADCs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a05ef04826825bab786355b4cfdf781
https://doi.org/10.1158/1535-7163.22508659
https://doi.org/10.1158/1535-7163.22508659
Autor:
Scott C. Jeffrey, Robert P. Lyon, Peter D. Senter, Ivan J. Stone, Weiping Zeng, Kim K. Emmerton, Brian E. Toki, Kristine A. Gordon, Andrew B. Waight, Julia H. Cochran, Joshua H. Hunter, Jocelyn R. Setter, Thomas A. Pires, Joseph Z. Hamilton, Patrick J. Burke
A quaternary ammonium-based drug-linker has been developed to expand the scope of antibody–drug conjugate (ADC) payloads to include tertiary amines, a functional group commonly present in biologically active compounds. The linker strategy was exemp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01277dcf190fe027b1aa165ef0569aff
https://doi.org/10.1158/1535-7163.c.6538699.v1
https://doi.org/10.1158/1535-7163.c.6538699.v1
Autor:
Scott C. Jeffrey, Robert P. Lyon, Peter D. Senter, Ivan J. Stone, Weiping Zeng, Kim K. Emmerton, Brian E. Toki, Kristine A. Gordon, Andrew B. Waight, Julia H. Cochran, Joshua H. Hunter, Jocelyn R. Setter, Thomas A. Pires, Joseph Z. Hamilton, Patrick J. Burke
Pharmacokinetic profile of clearance for three ADCs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f40a60bf104249e877111afed1bfdb6
https://doi.org/10.1158/1535-7163.22507471
https://doi.org/10.1158/1535-7163.22507471
Autor:
Scott C. Jeffrey, Robert P. Lyon, Peter D. Senter, Ivan J. Stone, Weiping Zeng, Kim K. Emmerton, Brian E. Toki, Kristine A. Gordon, Andrew B. Waight, Julia H. Cochran, Joshua H. Hunter, Jocelyn R. Setter, Thomas A. Pires, Joseph Z. Hamilton, Patrick J. Burke
Plasma stability of quaternary ammonium linker in rodent plasma.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af650b3133fc7e21796e5772ffd33361
https://doi.org/10.1158/1535-7163.22507474
https://doi.org/10.1158/1535-7163.22507474
Autor:
Scott C. Jeffrey, Robert P. Lyon, Peter D. Senter, Andrew B. Waight, Kim K. Emmerton, Christopher I. Leiske, Holden W.H. Lai, Thomas A. Pires, Joseph Z. Hamilton, Patrick J. Burke
Description of stability experiment, rat tolerability, and chemistry experimentals.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8545217e120f13a7701a117352def7c4
https://doi.org/10.1158/1535-7163.22505308
https://doi.org/10.1158/1535-7163.22505308
Autor:
Scott C. Jeffrey, Robert P. Lyon, Peter D. Senter, Ivan J. Stone, Weiping Zeng, Kim K. Emmerton, Brian E. Toki, Kristine A. Gordon, Andrew B. Waight, Julia H. Cochran, Joshua H. Hunter, Jocelyn R. Setter, Thomas A. Pires, Joseph Z. Hamilton, Patrick J. Burke
Experimental details for the chemical synthesis of the drug-linkers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b83380d151e3b1739d6b2739f97589
https://doi.org/10.1158/1535-7163.22507477.v1
https://doi.org/10.1158/1535-7163.22507477.v1
Autor:
Scott C. Jeffrey, Robert P. Lyon, Peter D. Senter, Andrew B. Waight, Kim K. Emmerton, Christopher I. Leiske, Holden W.H. Lai, Thomas A. Pires, Joseph Z. Hamilton, Patrick J. Burke
ADC in vivo stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544284ac7c42c7f37803db684e2072e0
https://doi.org/10.1158/1535-7163.22505314.v1
https://doi.org/10.1158/1535-7163.22505314.v1