Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Robert Oostrum"'
Publikováno v:
Cytometry. 24:123-130
Plasma membrane binding of annexin V was used to detect and quantitate apoptotic cells induced by cytotoxic drug treatment in epithelial cell cultures. Chinese hamster ovary (CHO) cells were incubated for 2 h with the ID90 concentration of Cisplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1462af9c766a43a6042ff02f313b7fcd
https://doi.org/10.1002/(sici)1097-0320(19960601)24:2<123::aid-cyto4>3.0.co
https://doi.org/10.1002/(sici)1097-0320(19960601)24:2<123::aid-cyto4>3.0.co
Autor:
Robert Oostrum, Gerrit Stoter, Kees Nooter, Herman Burger, A. G. Jochemsen, Antonius W. M. Boersma
Publikováno v:
British Journal of Cancer
Drugs used in anti-cancer chemotherapy are thought to exert their cytotoxic action by induction of apoptosis. Genes have been identified which can mediate or modulate this drug-induced apoptosis, among which are c-myc, p53 and bcl-2. Since expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f329308fcfa212f04e54bbd301666ba
https://doi.org/10.1038/bjc.1995.109
https://doi.org/10.1038/bjc.1995.109
Publikováno v:
International Journal of Cancer. 45:263-268
Typical multi-drug resistance (MDR) in human and animal cell lines is caused by overactivity of a unidirectional drug efflux pump. This pump is composed of a 170-kDa transmembrane glycoprotein (P-glycoprotein) that is encoded by the so-called mdr1 ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf531ced52988d75cc199914e75a85fb
https://doi.org/10.1002/ijc.2910450210
https://doi.org/10.1002/ijc.2910450210
Autor:
Robert Oostrum, G. Stoter, K. Nooter, Antonius W. M. Boersma, R.J. Scheper, Fred T. Bosman, A. van der Gaast, Herman Burger, M. J. Flens, K. E. Van Wingerden
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 7(1)
Summary Background: One of the major problems in the cure of advanced non-small-cell lung cancer (NSCLC) is its lack of response to cytotoxic drug treatment, and the mechanisms underlying this intrinsic drug resistance are unclear. Patients and metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f25b989c383530c4deb0a469583216c
https://pubmed.ncbi.nlm.nih.gov/9081396
https://pubmed.ncbi.nlm.nih.gov/9081396
Autor:
D Valerio, Pieter Sonneveld, Kees Nooter, Anne Hagemeijer, T Boersma, A. L. W. Janssen, Frank Baas, Robert Oostrum, Hans Herweijer
Publikováno v:
International journal of cancer. 45(4)
Typical multidrug resistance in human and animal cell lines is caused by overactivity of an unidirectional transmembrane drug efflux pump, encoded by the MDR genes, called mdr genes in mice and humans and pgp genes in hamsters. In humans, two mdr gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12966b8adb8a250ad27ec82b63807fb9
https://pubmed.ncbi.nlm.nih.gov/2323839
https://pubmed.ncbi.nlm.nih.gov/2323839
Autor:
Robert Oostrum, Arjenne L.W. Hesseling-Janssen, Auke Beishuizen, Pieter Sonneveld, Kees Nooter, Hans Herweijer, Jacques J.M. van Dongen
Publikováno v:
European Journal of Cancer and Clinical Oncology. 27:297-298
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bde4e965589f0bcb7e2f61a3811e05
https://doi.org/10.1016/0277-5379(91)90524-h
https://doi.org/10.1016/0277-5379(91)90524-h
Publikováno v:
Experientia. 40:559-561
After a single oral dose of cyclosporin A (82 mg/kg) in rats, tissue (kidneys liver and brain) and blood levels reached maximum values (approximately 80 micrograms/g and 3.5 micrograms/ml) between 3 and 7 h after drug administration. Drug elimination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fca637f20a40602895cccb03ec83af
https://doi.org/10.1007/bf01982329
https://doi.org/10.1007/bf01982329
Publikováno v:
Cancer Chemotherapy and Pharmacology. 20
We compared the pharmacokinetics of daunomycin in two groups of rats: one group was treated with daunomycin (7.5 mg/kg) alone and the other group was treated with daunomycin (7.5 mg/kg) plus the calcium antagonist verapamil (2 X 50 mg/kg i.p.). Due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a005cd69ea121b86aa2266b6b6a1dbb5
https://doi.org/10.1007/bf00253975
https://doi.org/10.1007/bf00253975
Autor:
Robert Oostrum, Anton C.M. Martens, Kees Nooter, Frank W. Schultz, Anton Hagenbeek, Pieter Sonneveld, Jan Deurloo
Publikováno v:
Cancer Chemotherapy and Pharmacology. 12
In the experiments described here, rats received three IV bolus injections (7.5 mg/kg) of daunomycin. The plasma data obtained after a single IV injection could be described by a two-compartment open model with t1/2 alpha and t1/2 beta values of 18.4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aefbf1f15b769fa0a02b84abfcde3be4
https://doi.org/10.1007/bf00256543
https://doi.org/10.1007/bf00256543
Autor:
Kees Nooter, Herman van Dekken, Ger van den Engh, Richard Jonker, Robert Oostrum, Willem Stokdijk
Publikováno v:
Cancer chemotherapy and pharmacology. 23(5)
We investigated the mode of action of cyclosporin A (Cy-A) as a modifier of multidrug resistance in P388 mouse leukemia cells. A fluorescence-activated flow cytometer (FCM) was modified with a flow-through cuvette to allow continuous on-line monitori
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ed94516a07d7a07b12218e83783023
https://pubmed.ncbi.nlm.nih.gov/2706734
https://pubmed.ncbi.nlm.nih.gov/2706734