Zobrazeno 1 - 10
of 213
pro vyhledávání: '"Robert O. Williams III"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100164- (2023)
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various benefits, inc
Externí odkaz:
https://doaj.org/article/397e8ca481b44db795a6e2b1585d7a13
Autor:
Stephanie Hufnagel, Sawittree Sahakijpijarn, Chaeho Moon, Zhengrong Cui, Robert O. Williams III
Publikováno v:
KONA Powder and Particle Journal, Vol 39, Iss 0, Pp 176-192 (2021)
While the formulation of pharmaceuticals as liquids is common practice, powders are associated with enhanced stability, avoidance of the cold chain, lower dosing requirements, and more convenient administration. These are particularly critical for pr
Externí odkaz:
https://doaj.org/article/871a9c73f16b493e9840cd4c568a49e8
Autor:
Marla R. Wolfson, Perenlei Enkhbaatar, Satoshi Fukuda, Christina L. Nelson, Robert O. Williams III, Soraya Hengsawas Surasarang, Sawittree Sahakijpijarn, Gennaro Calendo, Andrey A. Komissarov, Galina Florova, Krishna Sarva, Steven I. Idell, Thomas H. Shaffer
Publikováno v:
Clinical and Translational Medicine, Vol 10, Iss 1, Pp 258-274 (2020)
Abstract Background Effective clinical management of airway clot and fibrinous cast formation of severe inhalational smoke‐induced acute lung injury (ISALI) is lacking. Aerosolized delivery of tissue plasminogen activator (tPA) is confounded by air
Externí odkaz:
https://doaj.org/article/bad4ee72bd4245768ebac4aaa4449de0
Autor:
Sawittree Sahakijpijarn, Chaeho Moon, Zachary N. Warnken, Esther Y. Maier, Jennie E. DeVore, Dale J. Christensen, John J. Koleng, Robert O. Williams, III
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100073- (2021)
Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 leve
Externí odkaz:
https://doaj.org/article/dfe6a274c8314e9c8f760034807a44c2
Autor:
Daniel A. Davis, Jr, Dave A. Miller, Supawan Santitewagun, J. Axel Zeitler, Yongchao Su, Robert O. Williams, III
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100092- (2021)
We seek to further addresss the questions posed by Moseson et al. regarding whether any residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion (ASD) such that its stability, enhanced dissolution, and increased
Externí odkaz:
https://doaj.org/article/99a533e6ece349858e1b1e00f0811dc7
Autor:
Salma Salem, Stephen R. Byrn, Daniel Smith, Vadim J. Gurvich, Stephen W. Hoag, Feng Zhang, Robert O. Williams III, Kari L. Clase
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8eb6872fb9b2edce47911cf8cb6fc83c
https://doi.org/10.2139/ssrn.4019138
https://doi.org/10.2139/ssrn.4019138
Autor:
Junhuang Jiang, Han-Hsuan Peng, Zhenpei Yang, Xiangyu Ma, Sawittree Sahakijpijarn, Chaeho Moon, Defang Ouyang, Robert O. Williams III
Publikováno v:
International Journal of Pharmaceutics. 626:122179
Dry powder inhalers (DPIs) are one of the most widely used devices for treating respiratory diseases. Thin--film--freezing (TFF) is a particle engineering technology that has been demonstrated to prepare dry powder for inhalation with enhanced physic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231a25198751ff288ebde80175005824
https://doi.org/10.1016/j.ijpharm.2022.122179
https://doi.org/10.1016/j.ijpharm.2022.122179
Autor:
Khaled, AboulFotouh, Naoko, Uno, Haiyue, Xu, Chaeho, Moon, Sawittree, Sahakijpijarn, Dale J, Christensen, Gregory J, Davenport, Chris, Cano, Ted M, Ross, Robert O, Williams Iii, Zhengrong, Cui
Publikováno v:
International Journal of Pharmaceutics. 624:122021
MF59® is an oil-in-water (O/W) nanoemulsion-based vaccine adjuvant that is often used in seasonal and pandemic influenza vaccines. We explored the feasibility of developing dry powders of vaccines adjuvanted with MF59 or AddaVax™, a preclinical gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9ef14752c3d5453f07e05fad447cab7
https://doi.org/10.1016/j.ijpharm.2022.122021
https://doi.org/10.1016/j.ijpharm.2022.122021