Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Robert O. Williams, III"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100164- (2023)
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various benefits, inc
Externí odkaz:
https://doaj.org/article/397e8ca481b44db795a6e2b1585d7a13
Autor:
Sawittree Sahakijpijarn, Chaeho Moon, Zachary N. Warnken, Esther Y. Maier, Jennie E. DeVore, Dale J. Christensen, John J. Koleng, Robert O. Williams, III
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100073- (2021)
Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 leve
Externí odkaz:
https://doaj.org/article/dfe6a274c8314e9c8f760034807a44c2
Autor:
Daniel A. Davis, Jr, Dave A. Miller, Supawan Santitewagun, J. Axel Zeitler, Yongchao Su, Robert O. Williams, III
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100092- (2021)
We seek to further addresss the questions posed by Moseson et al. regarding whether any residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion (ASD) such that its stability, enhanced dissolution, and increased
Externí odkaz:
https://doaj.org/article/99a533e6ece349858e1b1e00f0811dc7
Autor:
Marla R. Wolfson, Perenlei Enkhbaatar, Satoshi Fukuda, Christina L. Nelson, Robert O. Williams III, Soraya Hengsawas Surasarang, Sawittree Sahakijpijarn, Gennaro Calendo, Andrey A. Komissarov, Galina Florova, Krishna Sarva, Steven I. Idell, Thomas H. Shaffer
Publikováno v:
Clinical and Translational Medicine, Vol 10, Iss 1, Pp 258-274 (2020)
Abstract Background Effective clinical management of airway clot and fibrinous cast formation of severe inhalational smoke‐induced acute lung injury (ISALI) is lacking. Aerosolized delivery of tissue plasminogen activator (tPA) is confounded by air
Externí odkaz:
https://doaj.org/article/bad4ee72bd4245768ebac4aaa4449de0
Autor:
Salma Salem, Stephen R. Byrn, Daniel Smith, Vadim J. Gurvich, Stephen W. Hoag, Feng Zhang, Robert O. Williams III, Kari L. Clase
Publikováno v:
SSRN Electronic Journal.
Autor:
Junhuang Jiang, Han-Hsuan Peng, Zhenpei Yang, Xiangyu Ma, Sawittree Sahakijpijarn, Chaeho Moon, Defang Ouyang, Robert O. Williams III
Publikováno v:
International Journal of Pharmaceutics. 626:122179
Dry powder inhalers (DPIs) are one of the most widely used devices for treating respiratory diseases. Thin--film--freezing (TFF) is a particle engineering technology that has been demonstrated to prepare dry powder for inhalation with enhanced physic
Autor:
Khaled, AboulFotouh, Naoko, Uno, Haiyue, Xu, Chaeho, Moon, Sawittree, Sahakijpijarn, Dale J, Christensen, Gregory J, Davenport, Chris, Cano, Ted M, Ross, Robert O, Williams Iii, Zhengrong, Cui
Publikováno v:
International Journal of Pharmaceutics. 624:122021
MF59® is an oil-in-water (O/W) nanoemulsion-based vaccine adjuvant that is often used in seasonal and pandemic influenza vaccines. We explored the feasibility of developing dry powders of vaccines adjuvanted with MF59 or AddaVax™, a preclinical gr
Publikováno v:
AAPS Introductions in the Pharmaceutical Sciences ISBN: 9783030317447
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9354a1f02bf314ccd31d9d12ab092d9f
https://doi.org/10.1007/978-3-030-31745-4
https://doi.org/10.1007/978-3-030-31745-4
Particularly in healthcare fields, there is growing movement away from traditional lecture style course towards active learning and team-based activities to improve learning and build higher level thinking through application of complex problems with
The objective of this volume is to consolidate within a single text the most current knowledge, practical methods, and regulatory considerations pertaining to formulations development with poorly water-soluble molecules. A pharmaceutical scientist's