Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Robert O. A. Koch"'
Autor:
Alexandra Koschak, Hans-Günther Knaus, Gregory J. Kaczorowski, Siegmund G. Wanner, Robert O. A. Koch, Maria Trieb, Maria L. Garcia
Publikováno v:
Biochemistry. 38:5392-5400
In rat brain, high-conductance Ca2+-activated K+ (BK) channels are targeted to axons and nerve terminals [Knaus, H. G., et al. (1996) J. Neurosci. 16, 955-963], but absolute levels of their regional expression and subunit composition have not yet bee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8720976d644bb581dbf61ef4752fb77
https://doi.org/10.1021/bi983040c
https://doi.org/10.1021/bi983040c
Autor:
Robert O. A. Koch, Robert S. Slaughter, Hans-Günther Knaus, Siegmund G. Wanner, Markus Hanner, Maria L. Garcia, Alexandra Koschak, Christoph Schwarzer, Gregory J. Kaczorowski
Publikováno v:
Journal of Biological Chemistry. 272:27577-27581
Neurons require specific patterns of K+ channel subunit expression as well as the precise coassembly of channel subunits into heterotetrameric structures for proper integration and transmission of electrical signals. In vivo subunit coassembly was in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::25ca68b76d516b4bb626ce07d77764b9
https://doi.org/10.1074/jbc.272.44.27577
https://doi.org/10.1074/jbc.272.44.27577
Autor:
Hans-Günther Knaus, Siegmund G. Wanner, Maria L. Garcia, Reid J. Leonard, John P. Felix, Gregory J. Kaczorowski, Randal M. Bugianesi, Robert O. A. Koch, Scott P. Stevens, Lisa M. H. Helms, Robert S. Slaughter
Publikováno v:
Biochemistry. 36:3737-3744
Voltage-gated potassium (K(V)) channels play key roles in setting the resting potential and in the activation cascade of human peripheral T lymphocytes. Margatoxin (MgTX), a 39-amino acid peptide from Centruroides margaritatus, is a potent inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0a880467e6b335261e03716c0f3af7
https://doi.org/10.1021/bi962351p
https://doi.org/10.1021/bi962351p
Autor:
Robert O. A. Koch, Jessica Liu, Hans-Günther Knaus, Alexandra Koschak, Gregory J. Kaczorowski, Peter H. Reinhart, Maria L. Garcia
Publikováno v:
Biochemistry. 36:1943-1952
Iberiotoxin (IbTX), a selective peptidyl ligand for high-conductance Ca2(+)-activated K+ (maxi-K) channels cannot be radioiodinated in biologically active form due to the importance of Y36 in interacting with the channel pore. Therefore, an IbTX doub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22efaab055d43e4ad3b97c2a4041edba
https://doi.org/10.1021/bi962074m
https://doi.org/10.1021/bi962074m
Autor:
Robert O. A. Koch, Andreas Eberhart, Christoph Schwarzer, Hans-Günther Knaus, Maria L. Garcia, F. Wunder, G. Sperk, Olaf Pongs, Gregory J. Kaczorowski, Hartmut Glossmann
Publikováno v:
The Journal of Neuroscience. 16:955-963
Tissue expression and distribution of the high-conductance Ca(2+)- activated K+ channel Slo was investigated in rat brain by immunocytochemistry, in situ hybridization, and radioligand binding using the novel high-affinity (Kd 22 pM) ligand [3H]iberi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98b9786407a65fd0cb435f99b839e02
https://doi.org/10.1523/jneurosci.16-03-00955.1996
https://doi.org/10.1523/jneurosci.16-03-00955.1996
Autor:
Alois Saria, Robert O. A. Koch, Christian Humpel, Hans-Günther Knaus, H. Fischer, Siegmund G. Wanner, Stefan Telser, Maria L. Garcia, Christine V Seidl
Publikováno v:
European journal of pharmacology. 343(2-3)
The distribution of iodinated margatoxin ([125I]margatoxin) binding sites in rat was investigated by autoradiography. Rat striatum expresses a high density of margatoxin binding sites and, therefore, the effects of margatoxin, charybdotoxin and iberi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f40aa2198cd4152ed3ba288542b4c6a
https://pubmed.ncbi.nlm.nih.gov/9570467
https://pubmed.ncbi.nlm.nih.gov/9570467
Autor:
Gregory J. Kaczorowski, William A. Schmalhofer, Hans-Günther Knaus, Robert S. Slaughter, Maria L. Garcia, Robert O. A. Koch, Markus Hanner
Publikováno v:
Advances in Pharmacology ISBN: 9780120329403
Publisher Summary Potassium channels represent the largest and most diverse family of ion channels. K+ channels can be divided into two groups, voltage-gated and ligand-gated channels, depending on the stimulus that triggers the conformational change
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f75757009ab5dc1a6b93f15837ed3972
https://doi.org/10.1016/s1054-3589(08)60078-2
https://doi.org/10.1016/s1054-3589(08)60078-2
Autor:
Gregory J. Kaczorowski, Andreas Eberhart, Robert O. A. Koch, Maria L. Garcia, Hans-Guenther Knaus, Robert S. Slaughter
Publikováno v:
Biochemistry. 34(41)
Monoiodotyrosine margatoxin ([125I]MgTX) specifically and reversibly labels a maximum of 0.8 pmol of sites/mg of protein in purified rat brain synaptic plasma membrane vesicles with a dissociation constant of 0.1 pM under equilibrium binding conditio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b973038bedbc497ae524a0882cf261b
https://pubmed.ncbi.nlm.nih.gov/7577952
https://pubmed.ncbi.nlm.nih.gov/7577952