Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Robert O Sayers"'
Autor:
Priyanka Pandya, Robert O Sayers, Joey P Ting, Shaghayegh Morshedian, Carina Torres, Justine S Cudal, Kai Zhang, Jonathan R Fitchett, Qing Zhang, Feiyu F Zhang, Jing Wang, Jim D Durbin, Juan J Carrillo, Alfonso Espada, Howard Broughton, Yuewei Qian, Sepideh Afshar
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233961 (2020)
Hundreds of target specific peptides are routinely discovered by peptide display platforms. However, due to the high cost of peptide synthesis only a limited number of peptides are chemically made for further analysis. Here we describe an accurate an
Externí odkaz:
https://doaj.org/article/34b3432ac0334b28a6012c155f43114e
Autor:
Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
Publikováno v:
Journal of Medicinal Chemistry. 48:6779-6782
A series of oxamyl dipeptides were optimized for pan caspase inhibition, anti-apoptotic cellular activity and in vivo efficacy. This structure-activity relationship study focused on the P4 oxamides and warhead moieties. Primarily on the basis of in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e
https://doi.org/10.1021/jm050307e
Autor:
Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb680f6d4dacf778afb32ec56f318e3
https://doi.org/10.1016/j.bmcl.2003.12.106
https://doi.org/10.1016/j.bmcl.2003.12.106
Autor:
Edward D. Robinson, Silvio Roggo, Joe C. Wu, Robert J. Ternansky, Jose-Luis Diaz, Teresa Aja, Kevin J. Tomaselli, Steven P. Meduna, Vincent J. Kalish, Donald S. Karanewsky, Robert O. Sayers, Albert Schmitz, Brett R. Ullman, Julia Herrmann, Kip Nalley, Thomas L. Deckwerth
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:3623-3626
Various aryloxy methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A systematic study of their structure-activity relationship (SAR) related to caspases 1, 3, 6, and 8 is reported. Highly potent irreversible broad-spectrum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681ec055be84e31c81b8947185e1442d
https://doi.org/10.1016/s0960-894x(03)00755-8
https://doi.org/10.1016/s0960-894x(03)00755-8
Autor:
Teresa Aja, André Sauter, Donald S. Karanewsky, Markus Rudin, Rachel May, Peter R. Allegrini, Bastian Hengerer, Robert O. Sayers, Christoph Wiessner, Steve Linton, Albert Schmitz, Giorgio Rovelli, Kevin J. Tomaselli, Patricia C. Contreras, Joe C. Wu, Silvio Roggo, Kip Nalley, Lisa M. Adams, Thomas L. Deckwerth
Publikováno v:
Drug Development Research. 52:579-586
Apoptotic cell death occurs in the injured and diseased central nervous system. It is mediated by a family of caspases, which are activated by the lethal stimulus and cleave multiple protein substrates that are critical for cell viability. Previous s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa9ad16436d7f28cc9622c6484c77710
https://doi.org/10.1002/ddr.1161
https://doi.org/10.1002/ddr.1161
Autor:
Teresa Aja, Kevin J. Tomaselli, Edward D. Robinson, Joe C. Wu, Steven D. Linton, Xin Gu, Robert O. Sayers, Steven P. Meduna, Kip Nalley, Lalitha Kodandapani, Silvio Roggo, Vincent J. Kalish, Jose-Luis Diaz, Donald S. Karanewsky, Ning Chen, Albert Schmitz, Julia Herrmann, Brett R. Ullman, Joseph J. Krebs, Robert J. Ternansky
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(15)
Various heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A study of their structure-activity relationship (SAR) related to caspase-1, -3, -6, and -8 is reported. Their efficacy in a cellular model of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20fa9b2635d713c24eee1115cb07fa3
https://pubmed.ncbi.nlm.nih.gov/15964758
https://pubmed.ncbi.nlm.nih.gov/15964758
In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system
Autor:
Anu Srinivasan, Kevin J. Tomaselli, Kevin A. Roth, Lawrence C. Fritz, Kenneth S. Shindler, Robert O. Sayers, Angela M. Wong
Publikováno v:
Cell death and differentiation. 5(12)
Activation of caspase-3 requires proteolytic processing of the inactive zymogen into p18 and p12 subunits. We generated a rabbit polyclonal antiserum, CM1, which recognizes the p18 subunit of cleaved caspase-3 but not the zymogen. CM1 demonstrated an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba9e6ea29b5bfcafb9a4a7dac47ecde
https://pubmed.ncbi.nlm.nih.gov/9894607
https://pubmed.ncbi.nlm.nih.gov/9894607