Zobrazeno 1 - 10
of 313
pro vyhledávání: '"Robert O, Williams"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100164- (2023)
Amorphous solid dispersion (ASD) is one of the most important strategies to improve the solubility and dissolution rate of poorly water-soluble drugs. As a widely used technique to prepare ASDs, hot-melt extrusion (HME) provides various benefits, inc
Externí odkaz:
https://doaj.org/article/397e8ca481b44db795a6e2b1585d7a13
Akademický článek
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Autor:
Stephanie Hufnagel, Sawittree Sahakijpijarn, Chaeho Moon, Zhengrong Cui, Robert O. Williams III
Publikováno v:
KONA Powder and Particle Journal, Vol 39, Iss 0, Pp 176-192 (2021)
While the formulation of pharmaceuticals as liquids is common practice, powders are associated with enhanced stability, avoidance of the cold chain, lower dosing requirements, and more convenient administration. These are particularly critical for pr
Externí odkaz:
https://doaj.org/article/871a9c73f16b493e9840cd4c568a49e8
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1281 (2023)
This study compares the effects of pre-processing multiple polymers together to form a single-phase polymer alloy prior to amorphous solid dispersion formulation. KinetiSol compounding was used to pre-process a 1:1 (w/w) ratio of hypromellose acetate
Externí odkaz:
https://doaj.org/article/b767cc7bb93447ea8ff20db29e18e865
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
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Autor:
Marla R. Wolfson, Perenlei Enkhbaatar, Satoshi Fukuda, Christina L. Nelson, Robert O. Williams III, Soraya Hengsawas Surasarang, Sawittree Sahakijpijarn, Gennaro Calendo, Andrey A. Komissarov, Galina Florova, Krishna Sarva, Steven I. Idell, Thomas H. Shaffer
Publikováno v:
Clinical and Translational Medicine, Vol 10, Iss 1, Pp 258-274 (2020)
Abstract Background Effective clinical management of airway clot and fibrinous cast formation of severe inhalational smoke‐induced acute lung injury (ISALI) is lacking. Aerosolized delivery of tissue plasminogen activator (tPA) is confounded by air
Externí odkaz:
https://doaj.org/article/bad4ee72bd4245768ebac4aaa4449de0
Autor:
Sawittree Sahakijpijarn, Chaeho Moon, Zachary N. Warnken, Esther Y. Maier, Jennie E. DeVore, Dale J. Christensen, John J. Koleng, Robert O. Williams, III
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100073- (2021)
Remdesivir dry powder for inhalation was previously developed using thin film freezing (TFF). A single-dose 24-h pharmacokinetic study in hamsters demonstrated that pulmonary delivery of TFF remdesivir can achieve plasma remdesivir and GS-441524 leve
Externí odkaz:
https://doaj.org/article/dfe6a274c8314e9c8f760034807a44c2
Autor:
Daniel A. Davis, Jr, Dave A. Miller, Supawan Santitewagun, J. Axel Zeitler, Yongchao Su, Robert O. Williams, III
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100092- (2021)
We seek to further addresss the questions posed by Moseson et al. regarding whether any residual crystal level, size, or characteristic is acceptable in an amorphous solid dispersion (ASD) such that its stability, enhanced dissolution, and increased
Externí odkaz:
https://doaj.org/article/99a533e6ece349858e1b1e00f0811dc7
Autor:
Miguel O. Jara, Zachary N. Warnken, Sawittree Sahakijpijarn, Rishi Thakkar, Vineet R. Kulkarni, Dale J. Christensen, John J. Koleng, Robert O. Williams
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2568 (2022)
Niclosamide is an FDA-approved anthelmintic that is being studied in clinical trials as a chemotherapeutic and broad-spectrum antiviral. Additionally, several other applications are currently in the preclinical stage. Unfortunately, niclosamide is a
Externí odkaz:
https://doaj.org/article/d5988db7ec374c72851dc142892f2f1e
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2257 (2022)
Artificial Intelligence (AI)-based formulation development is a promising approach for facilitating the drug product development process. AI is a versatile tool that contains multiple algorithms that can be applied in various circumstances. Solid dos
Externí odkaz:
https://doaj.org/article/5f2b00294f5f4a91a2cf784833af7fdc