Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Robert Nutbrown"'
Autor:
Michael Dickinson, Giuseppe Gritti, Carmelo Carlo-Stella, Harriet S Walter, David Carlile, Nicole Getzmann, Samira Curdt, Emma Harrop, Abiraj Keelara, Koorosh Korfi, Remi Labatut, Francesca Michielin, Sarah Louise Mycroft, Tom Moore, Robert Nutbrown, Giuseppe Palldino, Matt Whayman, Johannes Sam, Martin Weisser, Katharina E Lechner, Franck Morschhauser, Martin Hutchings
Publikováno v:
Blood. 140:3818-3820
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89ce2aa3e768ba1d8a7a06788cc9a1a8
https://doi.org/10.1182/blood-2022-156808
https://doi.org/10.1182/blood-2022-156808
Autor:
Martin Hutchings, Carmelo Carlo-Stella, Giuseppe Gritti, Francesc Bosch, Franck Morschhauser, William Townsend, Fritz Offner, Harriet S Walter, Herve Ghesquieres, Roch Houot, Guillaume Cartron, Natalie Dimier, Stephen Fowler, Emma Harrop, Sylvia Herter, Abiraj Keelara, Koorosh Korfi, Jeff Luong, Claudia Mueller, Robert Nutbrown, Giuseppe Palldino, Matt Whayman, Isabel Prieto, Sarah Louise Mycroft, Daria Rukina, Katharina E Lechner, Michael Dickinson
Publikováno v:
Blood. 140:9461-9463
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c74eda49a62af699ca90091e7e01d790
https://doi.org/10.1182/blood-2022-157011
https://doi.org/10.1182/blood-2022-157011
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
A) CT and MRI of patient with prolonged partial response with MTL-CEBPA treatment B) IFN-gamma, NFkB and IL6 trend at days 1, 8 and 15 following treatment and C) AFP change at from baseline to 4, 8 and 16 weeks on treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34ab81451fcfb34da9fcfeff4eda3c4e
https://doi.org/10.1158/1078-0432.22477086
https://doi.org/10.1158/1078-0432.22477086
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Supplementary Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c7e811910e435bac98f627935365fd
https://doi.org/10.1158/1078-0432.22477080.v1
https://doi.org/10.1158/1078-0432.22477080.v1
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Showing complete radiological response of lung metastases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77745179950de77a7a87e254666ef1c3
https://doi.org/10.1158/1078-0432.22477083.v1
https://doi.org/10.1158/1078-0432.22477083.v1
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Dose escalation flow chart. DLT - dose limiting toxicity, MTD - maximum tolerated dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f45e2fcc07497a12f923f330fe0e40d
https://doi.org/10.1158/1078-0432.22477095.v1
https://doi.org/10.1158/1078-0432.22477095.v1
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Trial Protocol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904983ab44a60b491e369e12d54f27a4
https://doi.org/10.1158/1078-0432.22477098
https://doi.org/10.1158/1078-0432.22477098
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Supplementary Table 1 CEBPA-51 PK parameters Supplementary Table 2 RECIST 1.1 response observed overall and per cohorts in HCC patients at cut-off (12 Sep 2018) presented as n (%)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce35daac7a415cf4cb7dfd189462b42
https://doi.org/10.1158/1078-0432.22477077.v1
https://doi.org/10.1158/1078-0432.22477077.v1
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Purpose:Transcription factor C/EBP-α (CCAAT/enhancer-binding protein alpha) acts as a master regulator of hepatic and myeloid functions and multiple oncogenic processes. MTL-CEBPA is a first-in-class small activating RNA oligonucleotide drug that up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655dfedd00417d62da05144f7bcb5f4f
https://doi.org/10.1158/1078-0432.c.6529569
https://doi.org/10.1158/1078-0432.c.6529569
Autor:
Nagy Habib, John J. Rossi, David C. Blakey, Hans E. Huber, Pal Saetrom, Chris Wood, Robert Habib, Jenni Vasara, Steve Felstead, Peter Lloyd, Pinelopi Andrikakou, Stephanie Dorman, Jon Voutila, Vikash Reebye, Sonia Fairbairn, Helen Glenny, Robert Nutbrown, David Collin, Joanna P. Nicholls, Vineet Kwatra, Sarah Hunter, James Spicer, David J. Pinato, Rohini Sharma, Madhava Pai, Duncan R.C. Spalding, T.R. Jeff Evans, Yuk Ting Ma, Daniel H. Palmer, Kai-Wen Huang, Cheng Ean Chee, Bristi Basu, Mikael H. Sodergren, Tim Meyer, Ruth Plummer, Debashis Sarker
Longitudinal changes in WBC mRNA expression of CEBPA, adenosine, PD-1 & CXCR4 at screening, day2, 8 and 15 of a single patient treated in the 130mg/m2 cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1792a6da256cefb45e0af3543b920792
https://doi.org/10.1158/1078-0432.22477089.v1
https://doi.org/10.1158/1078-0432.22477089.v1