Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles.

Autor: Amanda Tivnan, Wayne Shannon Orr, Vladimir Gubala, Robert Nooney, David E Williams, Colette McDonagh, Suzanne Prenter, Harry Harvey, Raquel Domingo-Fernández, Isabella M Bray, Olga Piskareva, Catherine Y Ng, Holger N Lode, Andrew M Davidoff, Raymond L Stallings

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e38129 (2012)

Neuroblastoma is one of the most challenging malignancies of childhood, being associated with the highest death rate in paediatric oncology, underlining the need for novel therapeutic approaches. Typically, patients with high risk disease undergo an

Externí odkaz: https://doaj.org/article/47f405808c1e47beba247e028b8bf54f

Highly sensitive detection of C-reactive protein using a novel dissolution approach in a dye-doped silica nanoparticle-based fluorescence immunoassay

Autor: Colette McDonagh, Daragh Byrne, Claire O'Connell, Gemma Keegan, Valerie Rebello, Robert Nooney

Publikováno v: Analytical Methods. 9:994-1003

A novel dissolution approach was used to achieve enhanced sensitivity in a nanoparticle (NP) immunoassay for the detection of a cardiovascular disease marker, C-reactive protein (CRP). In fluorescence-based assays using solid Cyanine5 doped silica na

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5d9ad33ca4e381e1f7a67faf79c47579
https://doi.org/10.1039/c6ay03362h

Synthesis and characterisation of far-red fluorescent cyanine dye doped silica nanoparticles using a modified microemulsion method for application in bioassays

Autor: Karla Boland, Robert Nooney, Colette McDonagh, Gemma Keegan, Shibsekhar Roy, Stephen Daniels, Claire O'Connell, Susan M. Kelleher

Publikováno v: Sensors and Actuators B: Chemical. 221:470-479

Silica nanoparticles (NPs) doped with far-red fluorescent cyanine dyes, Cy5 and FR670, were prepared using the microemulsion method. The effects of nucleation pathway on dye loading and NP morphology were investigated using UV–Vis spectroscopy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a63faeb38e21b4d8e00d09b61252546b
https://doi.org/10.1016/j.snb.2015.06.117

Cyanine5-doped silica nanoparticles as ultra-bright immunospecific labels for model circulating tumour cells in flow cytometry and microscopy

Autor: Colette McDonagh, Claire O'Connell, Robert Nooney

Publikováno v: Biosensorsbioelectronics. 91

In this work, ultra-bright fluorescent silica nanoparticles (NPs) labels have been shown to selectively bind to a model circulating tumour cell (CTC) line, MCF-7, a metastatic breast cancer by targeting epithelial cellular adhesion molecule (EpCAM) p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec62e8e16acd1b927e74162cfdd59e6b
https://pubmed.ncbi.nlm.nih.gov/28006688

Enhancing the analytical performance of immunoassays that employ metal-enhanced fluorescence

Autor: Brian D. MacCraith, Ondrej Stranik, Xavier LeGuevel, Robert Nooney, Andrew Clifford, Colette McDonagh

Publikováno v: Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry, Springer Verlag, 2010, 396 (3), pp.1127-1134. ⟨10.1007/s00216-009-3357-9⟩

International audience; In this work, we used a model assay system (polyclonal human IgG-goat antihuman IgG) to elucidate some of the key factors that influence the analytical performance of bioassays that employ metal-enhanced fluorescence (MEF) usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1e670875719ea7d0e8b795626b4c71
https://doi.org/10.1007/s00216-009-3357-9