Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Robert Nienhuis"'
Publikováno v:
The Journal of Neuroscience. 31:6305-6310
Hypocretin receptor-2 (Hcrt-r2)-mutated dogs exhibit all the major symptoms of human narcolepsy and respond to drugs that increase or decrease cataplexy as do narcoleptic humans; yet, unlike narcoleptic humans, the narcoleptic dogs have normal hypocr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbee7d1ff8225bfa822429a14d25803
https://doi.org/10.1523/jneurosci.0365-11.2011
https://doi.org/10.1523/jneurosci.0365-11.2011
Publikováno v:
Sleep. 32:993-998
Narcolepsy with cataplexy is characterized by a loss of approximately 90% of hypocretin (Hcrt) neurons. However, more than a quarter of narcoleptics do not have cataplexy and have normal levels of hypocretin in their cerebrospinal fluid, raising the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e5f66578eb2bf3c5e5578e2aca45855
https://doi.org/10.1093/sleep/32.8.993
https://doi.org/10.1093/sleep/32.8.993
Autor:
Ronald Szymusiak, Ruben Guzman-Marin, Robert Nienhuis, Dennis McGinty, Tariq Bashir, Natalia Suntsova
Publikováno v:
Sleep. 31:167-175
THE SUBGRANULAR CELL LAYER IN THE DENTATE GYRUS (DG) OF THE ADULT HIPPOCAMPUS CONTAINS PROGENITOR CELLS, WHICH HAVE THE POTENTIAL TO proliferate and differentiate into neurons. These progenitors mature locally into granule cells of the DG, sending ax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18aaaf592f00a9b2e88f316a7f0d56ac
https://doi.org/10.1093/sleep/31.2.167
https://doi.org/10.1093/sleep/31.2.167
Publikováno v:
Proceedings of the Water Environment Federation. 2008:8366-8373
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eddcb6bc655ee713520dff1c14c01d02
https://doi.org/10.2175/193864708790894025
https://doi.org/10.2175/193864708790894025
Publikováno v:
Brain Pathol
Human narcolepsy is correlated with a greatly reduced number of hypocretin (orexin) containing neurons and axons, and an elevated level of hypothalamic gliosis. We now report that the percentage loss of Hcrt cells and percentage elevation of GFAP sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a806610f414a41ec7ada4a98dbcc5e
https://doi.org/10.1111/j.1750-3639.2003.tb00033.x
https://doi.org/10.1111/j.1750-3639.2003.tb00033.x
Publikováno v:
Neuroscience
The amygdala plays an important role in the interpretation of emotionally significant stimuli and has strong projections to brainstem regions regulating muscle tone and sleep. Cataplexy, a symptom of narcolepsy, is a loss of muscle tone usually trigg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc19b1700edac86510146cd43ab0fd1e
https://doi.org/10.1016/s0306-4522(02)00089-1
https://doi.org/10.1016/s0306-4522(02)00089-1
Autor:
Lalini Ramanathan, Thomas C. Thannickal, Seema Gulyani, Michael S. Aldrich, Jerome M. Siegel, Robert Y. Moore, Robert Nienhuis, Marsha Cornford
Publikováno v:
Neuron
Murine and canine narcolepsy can be caused by mutations of the hypocretin (Hcrt) (orexin) precursor or Hcrt receptor genes. In contrast to these animal models, most human narcolepsy is not familial, is discordant in identical twins, and has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557ae87c1f95077111967d3bd610902b
Autor:
Robert Nienhuis, H. M. Fahringer, Jerome M. Siegel, T. Shalita, Paul R. Manger, John D. Pettigrew
Publikováno v:
Neuroscience
We have conducted the first study of sleep in the platypus Ornithorhynchus anatinus. Periods of quiet sleep, characterized by raised arousal thresholds, elevated electroencephalogram amplitude and motor and autonomic quiescence, occupied 6-8 h/day. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f380cffcb6acbd16f65f811316711f90
https://doi.org/10.1016/s0306-4522(98)00588-0
https://doi.org/10.1016/s0306-4522(98)00588-0
Autor:
H. M. Fahringer, Douglas A. Nitz, Jerome M. Siegel, Emmanuel Mignot, Robert Nienhuis, Angela Andersen
Publikováno v:
Neuroreport
NARCOLEPSY is characterized by excessive sleepiness and episodes of cataplexy brought on by emotional excitation. Cataplexy and sleep paralysis have been hypothesized to be produced by the triggering during waking of brain stem cholinergic mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcde2cd45b301dcb5930069e6400d80c
https://doi.org/10.1097/00001756-199507310-00014
https://doi.org/10.1097/00001756-199507310-00014
Publikováno v:
Epilepsia. 33:789-798
Summary: We previously described a model of spontaneous “sleep epilepsy” in kindled kittens with temporal lobe epilepsy (TLE). We now describe the postkindling course of this model from preadolescence to maturity and suggest pathophysiologic mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f40b9bce60a816111614b549ac275c
https://doi.org/10.1111/j.1528-1157.1992.tb02183.x
https://doi.org/10.1111/j.1528-1157.1992.tb02183.x